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Q5XHB2

- DUS22_XENTR

UniProt

Q5XHB2 - DUS22_XENTR

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Protein

Dual specificity protein phosphatase 22

Gene

dusp22

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) By similarity.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 22 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:dusp22
ORF Names:TEgg009e03.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-486791. dusp22.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Dual specificity protein phosphatase 22PRO_0000244755Add
BLAST

Expressioni

Gene expression databases

BgeeiQ5XHB2.
ExpressionAtlasiQ5XHB2. baseline.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000024913.

Structurei

3D structure databases

ProteinModelPortaliQ5XHB2.
SMRiQ5XHB2. Positions 1-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 13369Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
HOGENOMiHOG000007880.
HOVERGENiHBG054344.
InParanoidiQ5XHB2.
KOiK14165.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XHB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNGMNKILP SLFIGNFKDA RDVEQLHKNN ITHILSIHDS ARPMLEGMKY
60 70 80 90 100
LCIPASDSPS QNLIQHFKDS IAFIHECRLK GEGCLVHCLA GVSRSVTLVV
110 120 130 140 150
AYVMTVTDFG WEDALSAVRG ARTCANPNMG FQKQLEDFGK HDVYQFRTWL
160 170 180 190 200
KETYGENPFN DKDDAKQLLD KHKQQEAAES QSATSSGRQW SSHLTSLSSM

SYSNYTTET
Length:209
Mass (Da):23,453
Last modified:November 23, 2004 - v1
Checksum:i4BE280C266B742A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR762123 mRNA. Translation: CAJ81898.1.
BC084150 mRNA. Translation: AAH84150.1.
RefSeqiNP_001011043.1. NM_001011043.2.
UniGeneiStr.3482.

Genome annotation databases

GeneIDi496452.
KEGGixtr:496452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR762123 mRNA. Translation: CAJ81898.1 .
BC084150 mRNA. Translation: AAH84150.1 .
RefSeqi NP_001011043.1. NM_001011043.2.
UniGenei Str.3482.

3D structure databases

ProteinModelPortali Q5XHB2.
SMRi Q5XHB2. Positions 1-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000024913.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 496452.
KEGGi xtr:496452.

Organism-specific databases

CTDi 56940.
Xenbasei XB-GENE-486791. dusp22.

Phylogenomic databases

eggNOGi COG2453.
HOGENOMi HOG000007880.
HOVERGENi HBG054344.
InParanoidi Q5XHB2.
KOi K14165.

Gene expression databases

Bgeei Q5XHB2.
ExpressionAtlasi Q5XHB2. baseline.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiDUS22_XENTR
AccessioniPrimary (citable) accession number: Q5XHB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3