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Q5XHB2

- DUS22_XENTR

UniProt

Q5XHB2 - DUS22_XENTR

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Protein
Dual specificity protein phosphatase 22
Gene
dusp22, TEgg009e03.1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
  2. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 22 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:dusp22
    ORF Names:TEgg009e03.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-486791. dusp22.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Dual specificity protein phosphatase 22
    PRO_0000244755Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ5XHB2.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000024913.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XHB2.
    SMRiQ5XHB2. Positions 1-154.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 13369Tyrosine-protein phosphatase
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    HOGENOMiHOG000007880.
    HOVERGENiHBG054344.
    InParanoidiQ5XHB2.
    KOiK14165.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5XHB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNGMNKILP SLFIGNFKDA RDVEQLHKNN ITHILSIHDS ARPMLEGMKY    50
    LCIPASDSPS QNLIQHFKDS IAFIHECRLK GEGCLVHCLA GVSRSVTLVV 100
    AYVMTVTDFG WEDALSAVRG ARTCANPNMG FQKQLEDFGK HDVYQFRTWL 150
    KETYGENPFN DKDDAKQLLD KHKQQEAAES QSATSSGRQW SSHLTSLSSM 200
    SYSNYTTET 209
    Length:209
    Mass (Da):23,453
    Last modified:November 23, 2004 - v1
    Checksum:i4BE280C266B742A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR762123 mRNA. Translation: CAJ81898.1.
    BC084150 mRNA. Translation: AAH84150.1.
    RefSeqiNP_001011043.1. NM_001011043.2.
    UniGeneiStr.3482.

    Genome annotation databases

    GeneIDi496452.
    KEGGixtr:496452.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR762123 mRNA. Translation: CAJ81898.1 .
    BC084150 mRNA. Translation: AAH84150.1 .
    RefSeqi NP_001011043.1. NM_001011043.2.
    UniGenei Str.3482.

    3D structure databases

    ProteinModelPortali Q5XHB2.
    SMRi Q5XHB2. Positions 1-154.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000024913.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 496452.
    KEGGi xtr:496452.

    Organism-specific databases

    CTDi 56940.
    Xenbasei XB-GENE-486791. dusp22.

    Phylogenomic databases

    eggNOGi COG2453.
    HOGENOMi HOG000007880.
    HOVERGENi HBG054344.
    InParanoidi Q5XHB2.
    KOi K14165.

    Gene expression databases

    Bgeei Q5XHB2.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Egg.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiDUS22_XENTR
    AccessioniPrimary (citable) accession number: Q5XHB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: November 23, 2004
    Last modified: July 9, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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