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Protein

Dual specificity protein phosphatase 22

Gene

dusp22

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 22 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:dusp22
ORF Names:TEgg009e03.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-486791. dusp22.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002447551 – 209Dual specificity protein phosphatase 22Add BLAST209

Proteomic databases

PaxDbiQ5XHB2.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000024913.

Structurei

3D structure databases

ProteinModelPortaliQ5XHB2.
SMRiQ5XHB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 133Tyrosine-protein phosphataseAdd BLAST69

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
HOGENOMiHOG000007880.
HOVERGENiHBG054344.
InParanoidiQ5XHB2.
KOiK14165.
OrthoDBiEOG091G0NE0.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiView protein in Pfam
PF00782. DSPc. 1 hit.
PRINTSiPR01908. ADSPHPHTASE.
SMARTiView protein in SMART
SM00195. DSPc. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XHB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNGMNKILP SLFIGNFKDA RDVEQLHKNN ITHILSIHDS ARPMLEGMKY
60 70 80 90 100
LCIPASDSPS QNLIQHFKDS IAFIHECRLK GEGCLVHCLA GVSRSVTLVV
110 120 130 140 150
AYVMTVTDFG WEDALSAVRG ARTCANPNMG FQKQLEDFGK HDVYQFRTWL
160 170 180 190 200
KETYGENPFN DKDDAKQLLD KHKQQEAAES QSATSSGRQW SSHLTSLSSM

SYSNYTTET
Length:209
Mass (Da):23,453
Last modified:November 23, 2004 - v1
Checksum:i4BE280C266B742A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762123 mRNA. Translation: CAJ81898.1.
BC084150 mRNA. Translation: AAH84150.1.
RefSeqiNP_001011043.1. NM_001011043.2.
UniGeneiStr.3482.

Genome annotation databases

GeneIDi496452.
KEGGixtr:496452.

Similar proteinsi

Entry informationi

Entry nameiDUS22_XENTR
AccessioniPrimary (citable) accession number: Q5XHB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 23, 2004
Last modified: August 30, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families