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Q5XHB2 (DUS22_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase 22

EC=3.1.3.16
EC=3.1.3.48
Gene names
Name:dusp22
ORF Names:TEgg009e03.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Dual specificity protein phosphatase 22
PRO_0000244755

Regions

Domain65 – 13369Tyrosine-protein phosphatase

Sites

Active site881Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5XHB2 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 4BE280C266B742A3

FASTA20923,453
        10         20         30         40         50         60 
MGNGMNKILP SLFIGNFKDA RDVEQLHKNN ITHILSIHDS ARPMLEGMKY LCIPASDSPS 

        70         80         90        100        110        120 
QNLIQHFKDS IAFIHECRLK GEGCLVHCLA GVSRSVTLVV AYVMTVTDFG WEDALSAVRG 

       130        140        150        160        170        180 
ARTCANPNMG FQKQLEDFGK HDVYQFRTWL KETYGENPFN DKDDAKQLLD KHKQQEAAES 

       190        200 
QSATSSGRQW SSHLTSLSSM SYSNYTTET 

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR762123 mRNA. Translation: CAJ81898.1.
BC084150 mRNA. Translation: AAH84150.1.
RefSeqNP_001011043.1. NM_001011043.2.
UniGeneStr.3482.

3D structure databases

ProteinModelPortalQ5XHB2.
SMRQ5XHB2. Positions 1-154.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000024913.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID496452.
KEGGxtr:496452.

Organism-specific databases

CTD56940.
XenbaseXB-GENE-486791. dusp22.

Phylogenomic databases

eggNOGCOG2453.
HOGENOMHOG000007880.
HOVERGENHBG054344.
InParanoidQ5XHB2.
KOK14165.

Gene expression databases

BgeeQ5XHB2.

Family and domain databases

InterProIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUS22_XENTR
AccessionPrimary (citable) accession number: Q5XHB2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families