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Protein

Calcium-binding mitochondrial carrier protein SCaMC-2

Gene

slc25a25

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-dependent mitochondrial solute carrier.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi68 – 791PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi104 – 1152PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-2
Alternative name(s):
Small calcium-binding mitochondrial carrier protein 2
Solute carrier family 25 member 25
Gene namesi
Name:slc25a25
Synonyms:scamc2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5933194. slc25a25.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 233Mitochondrial intermembraneSequence analysisAdd BLAST233
Transmembranei234 – 251Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini252 – 288Mitochondrial matrixSequence analysisAdd BLAST37
Transmembranei289 – 308Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini309 – 331Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei332 – 345Helical; Name=3Sequence analysisAdd BLAST14
Topological domaini346 – 381Mitochondrial matrixSequence analysisAdd BLAST36
Transmembranei382 – 401Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini402 – 424Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei425 – 442Helical; Name=5Sequence analysisAdd BLAST18
Topological domaini443 – 481Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei482 – 501Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini502 – 513Mitochondrial intermembraneSequence analysisAdd BLAST12

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176081 – 513Calcium-binding mitochondrial carrier protein SCaMC-2Add BLAST513

Proteomic databases

PaxDbiQ5XH95.

Expressioni

Gene expression databases

BgeeiENSXETG00000007731.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000016859.

Structurei

3D structure databases

ProteinModelPortaliQ5XH95.
SMRiQ5XH95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 90EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini91 – 124EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini122 – 157EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini158 – 193EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Repeati228 – 314Solcar 1Add BLAST87
Repeati322 – 407Solcar 2Add BLAST86
Repeati419 – 507Solcar 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00880000137904.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ5XH95.
KOiK14684.
OMAiFWRHSTM.
OrthoDBiEOG091G0C8S.
TreeFamiTF313492.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 2 hits.
PF00153. Mito_carr. 3 hits.
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SMARTiView protein in SMART
SM00054. EFh. 4 hits.
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 4 hits.
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q5XH95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPRSLVSP LLSGVFCQCD TVGGAPHTHD TPASPSLAAA LAADPCGGLV
60 70 80 90 100
CGGPEHETRL QILFQELDVN KDGGICINDL AVGLKRLGVH RTELELRKIV
110 120 130 140 150
KAGDKDQDGQ LDFEEFVHYL RDHEKKLRLV FKSLDKKNDG RIDAQEIMQS
160 170 180 190 200
LRDLGVNISE QQAEKILKSM DKNGTMTIDW NEWRDYHLLH PAENIPEIIL
210 220 230 240 250
YWKHSTIFDV GENLLVPDEF TVEEKQTGMW WRHLVAGGGA GAVSRTCTAP
260 270 280 290 300
LDRLKVLMQV HASRSNNMSM LGGFTQMIRE GGIRSLWRGN GINVIKIAPE
310 320 330 340 350
SAIKFMAYEQ MKRIIGSDQE TLGIHERLVA GSLAGVIAQS SIYPMEVLKT
360 370 380 390 400
RMALRKTGQY QGMLDCGKKI LLKEGVSAFY KGYVPNMLGI IPYAGIDLAV
410 420 430 440 450
YETLKNAWLQ RYATSSADPG VFVLLACGTI SSTCGQLASY PLALVRTRMQ
460 470 480 490 500
AEASVEGAPQ MTMSKLFKHI VKTEGAFGLY RGLAPNFMKV IPAVSISYVV
510
YENLKLTLGV QSR
Length:513
Mass (Da):56,640
Last modified:November 23, 2004 - v1
Checksum:iD49A0D6AF17E7512
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084177 mRNA. Translation: AAH84177.1.
RefSeqiNP_001011052.1. NM_001011052.1.
UniGeneiStr.2098.
Str.26254.

Genome annotation databases

EnsembliENSXETT00000016859; ENSXETP00000016859; ENSXETG00000007731.
GeneIDi496462.
KEGGixtr:496462.

Similar proteinsi

Entry informationi

Entry nameiSCMC2_XENTR
AccessioniPrimary (citable) accession number: Q5XH95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 23, 2004
Last modified: August 30, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families