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Q5XGM3 (BHMT1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Betaine--homocysteine S-methyltransferase 1

EC=2.1.1.5
Gene names
Name:bhmt
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline By similarity.

Catalytic activity

Trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 Hcy-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403Betaine--homocysteine S-methyltransferase 1
PRO_0000273222

Regions

Domain8 – 311304Hcy-binding

Sites

Metal binding2141Zinc By similarity
Metal binding2961Zinc By similarity
Metal binding2971Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5XGM3 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: D7FAFA7DD70F3782

FASTA40344,181
        10         20         30         40         50         60 
MAPVGAKKGL LERLDAGEVV IGDGGFVFAL EKRGYVKAGP WTPEAAVEHP EAVRQLHREF 

        70         80         90        100        110        120 
LRAGANVMQT FTFYASDDKL ENRGNYVAEK ISGQKVNEVA CDIAREVANE GDALVAGGVS 

       130        140        150        160        170        180 
QTPSYLSCKS EVEVKGIFRK QLDVFIKKNV DFLIAEYFEH VEEAVWAVEV LKESGKPVAA 

       190        200        210        220        230        240 
TLCIGPEGDL NGVSPGECAV RLAKAGASVV GVNCHFDPMT CVATVKLMKE GLVAAKVKAH 

       250        260        270        280        290        300 
LMTQPLAYHT PDCGKQGFID LPEFPFALEP RIVTRWDIHK YARAAYDLGV RYIGGCCGFE 

       310        320        330        340        350        360 
PYHTRAIAEE LAPERGFLPK GSEKHGSWGS GLEMHTKPWV RARARRDYWE KLPPASGRPY 

       370        380        390        400 
CPSMSKPDEW GVTKGDADLM QQKEATTEQQ LKDLIAKQGI KSN 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC084414 mRNA. Translation: AAH84414.1.
RefSeqNP_001088416.1. NM_001094947.1.
UniGeneXl.21139.

3D structure databases

ProteinModelPortalQ5XGM3.
SMRQ5XGM3. Positions 7-394.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID495275.
KEGGxla:495275.

Organism-specific databases

CTD635.
XenbaseXB-GENE-1008388. bhmt.

Phylogenomic databases

HOVERGENHBG080367.
KOK00544.

Enzyme and pathway databases

UniPathwayUPA00051; UER00083.
UPA00291; UER00432.

Family and domain databases

Gene3D3.20.20.330. 1 hit.
InterProIPR017226. Betaine-hCys_S-MeTrfase_BHMT.
IPR003726. S_MeTrfase.
[Graphical view]
PfamPF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFPIRSF037505. Betaine_HMT. 1 hit.
SUPFAMSSF82282. SSF82282. 1 hit.
PROSITEPS50970. HCY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBHMT1_XENLA
AccessionPrimary (citable) accession number: Q5XGM3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 23, 2004
Last modified: October 16, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways