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Q5XGM3

- BHMT1_XENLA

UniProt

Q5XGM3 - BHMT1_XENLA

Protein

Betaine--homocysteine S-methyltransferase 1

Gene

bhmt

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline By similarity.By similarity

    Catalytic activityi

    Trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi214 – 2141ZincPROSITE-ProRule annotation
    Metal bindingi296 – 2961ZincPROSITE-ProRule annotation
    Metal bindingi297 – 2971ZincPROSITE-ProRule annotation

    GO - Molecular functioni

    1. betaine-homocysteine S-methyltransferase activity Source: UniProtKB-EC
    2. S-adenosylmethionine-homocysteine S-methyltransferase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. amino-acid betaine catabolic process Source: UniProtKB-UniPathway
    2. methionine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00051; UER00083.
    UPA00291; UER00432.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Betaine--homocysteine S-methyltransferase 1 (EC:2.1.1.5)
    Gene namesi
    Name:bhmt
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-1008388. bhmt.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 403403Betaine--homocysteine S-methyltransferase 1PRO_0000273222Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XGM3.
    SMRiQ5XGM3. Positions 7-394.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 311304Hcy-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Hcy-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG080367.
    KOiK00544.

    Family and domain databases

    Gene3Di3.20.20.330. 1 hit.
    InterProiIPR017226. Betaine-hCys_S-MeTrfase_BHMT.
    IPR003726. S_MeTrfase.
    [Graphical view]
    PfamiPF02574. S-methyl_trans. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037505. Betaine_HMT. 1 hit.
    SUPFAMiSSF82282. SSF82282. 1 hit.
    PROSITEiPS50970. HCY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5XGM3-1 [UniParc]FASTAAdd to Basket

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    MAPVGAKKGL LERLDAGEVV IGDGGFVFAL EKRGYVKAGP WTPEAAVEHP    50
    EAVRQLHREF LRAGANVMQT FTFYASDDKL ENRGNYVAEK ISGQKVNEVA 100
    CDIAREVANE GDALVAGGVS QTPSYLSCKS EVEVKGIFRK QLDVFIKKNV 150
    DFLIAEYFEH VEEAVWAVEV LKESGKPVAA TLCIGPEGDL NGVSPGECAV 200
    RLAKAGASVV GVNCHFDPMT CVATVKLMKE GLVAAKVKAH LMTQPLAYHT 250
    PDCGKQGFID LPEFPFALEP RIVTRWDIHK YARAAYDLGV RYIGGCCGFE 300
    PYHTRAIAEE LAPERGFLPK GSEKHGSWGS GLEMHTKPWV RARARRDYWE 350
    KLPPASGRPY CPSMSKPDEW GVTKGDADLM QQKEATTEQQ LKDLIAKQGI 400
    KSN 403
    Length:403
    Mass (Da):44,181
    Last modified:November 23, 2004 - v1
    Checksum:iD7FAFA7DD70F3782
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC084414 mRNA. Translation: AAH84414.1.
    RefSeqiNP_001088416.1. NM_001094947.1.
    UniGeneiXl.21139.

    Genome annotation databases

    GeneIDi495275.
    KEGGixla:495275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC084414 mRNA. Translation: AAH84414.1 .
    RefSeqi NP_001088416.1. NM_001094947.1.
    UniGenei Xl.21139.

    3D structure databases

    ProteinModelPortali Q5XGM3.
    SMRi Q5XGM3. Positions 7-394.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 495275.
    KEGGi xla:495275.

    Organism-specific databases

    CTDi 635.
    Xenbasei XB-GENE-1008388. bhmt.

    Phylogenomic databases

    HOVERGENi HBG080367.
    KOi K00544.

    Enzyme and pathway databases

    UniPathwayi UPA00051 ; UER00083 .
    UPA00291 ; UER00432 .

    Family and domain databases

    Gene3Di 3.20.20.330. 1 hit.
    InterProi IPR017226. Betaine-hCys_S-MeTrfase_BHMT.
    IPR003726. S_MeTrfase.
    [Graphical view ]
    Pfami PF02574. S-methyl_trans. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037505. Betaine_HMT. 1 hit.
    SUPFAMi SSF82282. SSF82282. 1 hit.
    PROSITEi PS50970. HCY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiBHMT1_XENLA
    AccessioniPrimary (citable) accession number: Q5XGM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3