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Q5XGL6 (HOGA1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
EC=4.1.3.16
Alternative name(s):
Dihydrodipicolinate synthase-like
Short name=DHDPS-like protein
Probable 2-keto-4-hydroxyglutarate aldolase
Short name=Probable KHG-aldolase
Gene names
Name:hoga1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the final step in the metabolic pathway of hydroxyproline By similarity.

Catalytic activity

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

Enzyme regulation

Inhibited by divalent cations By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the DapA family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandSchiff base
   Molecular functionLyase
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function4-hydroxy-2-oxoglutarate aldolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2424Mitochondrion Potential
Chain25 – 326302Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
PRO_0000273349

Regions

Region74 – 752Substrate binding By similarity

Sites

Active site1931Schiff-base intermediate with substrate By similarity
Site1651Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5XGL6 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 3F4279E411C5E542

FASTA32635,488
        10         20         30         40         50         60 
MFGRTLFPAR ALCSGLFKTP LRTLATRPAL SIGGIYPPIA TPFTDKEEVD YGKLHENLQK 

        70         80         90        100        110        120 
YCSFPFSGFV VQGSNGEYAY LTREERLEVV RRVRQAVPKE KLIMAGSGCE STQATIEMTV 

       130        140        150        160        170        180 
EMARSGADVV LVVTPSYYRG KMTSSALVHH YTKVADHSPV PVVLYSVPAN TGLDLPVDAV 

       190        200        210        220        230        240 
VTLSQHPNII GLKDSGGDIT RIGLIIHKTK HLGFQVLSGS AGFLLAGYSV GAVGGVCALA 

       250        260        270        280        290        300 
NVLGAQVCEL EKLCLNGRWQ EAKELQHRLI EPNSAVTRKF GIPGLKQAMD WFGFNGGKCR 

       310        320 
SPLLPLTEQE IKELRHIFTV NGWLSS

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC084421 mRNA. Translation: AAH84421.1.
RefSeqNP_001088351.1. NM_001094882.1.
UniGeneXl.48116.

3D structure databases

HSSPHSSP built from PDB template 1XL9 based on UniProtKB Q81WN7.
ProteinModelPortalQ5XGL6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID495193.
KEGGxla:495193.

Organism-specific databases

CTD112817.
XenbaseXB-GENE-957779. hoga1.

Phylogenomic databases

HOVERGENHBG081405.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
[Graphical view]
PANTHERPTHR12128. PTHR12128. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
PROSITEPS00665. DHDPS_1. False negative.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHOGA1_XENLA
AccessionPrimary (citable) accession number: Q5XGL6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 23, 2004
Last modified: March 6, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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