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Q5XGL6

- HOGA1_XENLA

UniProt

Q5XGL6 - HOGA1_XENLA

Protein

4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Gene

hoga1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the final step in the metabolic pathway of hydroxyproline.By similarity

    Catalytic activityi

    4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

    Enzyme regulationi

    Inhibited by divalent cations.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei165 – 1651Involved in proton transfer during cleavageBy similarity
    Active sitei193 – 1931Schiff-base intermediate with substrateBy similarity
    Binding sitei195 – 1951SubstrateBy similarity
    Binding sitei219 – 2191Substrate; via carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC:4.1.3.16)
    Alternative name(s):
    Dihydrodipicolinate synthase-like
    Short name:
    DHDPS-like protein
    Probable 2-keto-4-hydroxyglutarate aldolase
    Short name:
    Probable KHG-aldolase
    Gene namesi
    Name:hoga1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-957779. hoga1.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424MitochondrionSequence AnalysisAdd
    BLAST
    Chaini25 – 3263024-hydroxy-2-oxoglutarate aldolase, mitochondrialPRO_0000273349Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XGL6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni74 – 752Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the DapA family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG081405.
    KOiK18123.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    IPR020625. Dihydrodipicolinate_synth_AS.
    [Graphical view]
    PANTHERiPTHR12128. PTHR12128. 1 hit.
    PfamiPF00701. DHDPS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001365. DHDPS. 1 hit.
    PRINTSiPR00146. DHPICSNTHASE.
    PROSITEiPS00666. DHDPS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5XGL6-1 [UniParc]FASTAAdd to Basket

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    MFGRTLFPAR ALCSGLFKTP LRTLATRPAL SIGGIYPPIA TPFTDKEEVD    50
    YGKLHENLQK YCSFPFSGFV VQGSNGEYAY LTREERLEVV RRVRQAVPKE 100
    KLIMAGSGCE STQATIEMTV EMARSGADVV LVVTPSYYRG KMTSSALVHH 150
    YTKVADHSPV PVVLYSVPAN TGLDLPVDAV VTLSQHPNII GLKDSGGDIT 200
    RIGLIIHKTK HLGFQVLSGS AGFLLAGYSV GAVGGVCALA NVLGAQVCEL 250
    EKLCLNGRWQ EAKELQHRLI EPNSAVTRKF GIPGLKQAMD WFGFNGGKCR 300
    SPLLPLTEQE IKELRHIFTV NGWLSS 326
    Length:326
    Mass (Da):35,488
    Last modified:November 23, 2004 - v1
    Checksum:i3F4279E411C5E542
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC084421 mRNA. Translation: AAH84421.1.
    RefSeqiNP_001088351.1. NM_001094882.1.
    UniGeneiXl.48116.

    Genome annotation databases

    GeneIDi495193.
    KEGGixla:495193.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC084421 mRNA. Translation: AAH84421.1 .
    RefSeqi NP_001088351.1. NM_001094882.1.
    UniGenei Xl.48116.

    3D structure databases

    ProteinModelPortali Q5XGL6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 495193.
    KEGGi xla:495193.

    Organism-specific databases

    CTDi 112817.
    Xenbasei XB-GENE-957779. hoga1.

    Phylogenomic databases

    HOVERGENi HBG081405.
    KOi K18123.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    IPR020625. Dihydrodipicolinate_synth_AS.
    [Graphical view ]
    PANTHERi PTHR12128. PTHR12128. 1 hit.
    Pfami PF00701. DHDPS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001365. DHDPS. 1 hit.
    PRINTSi PR00146. DHPICSNTHASE.
    PROSITEi PS00666. DHDPS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiHOGA1_XENLA
    AccessioniPrimary (citable) accession number: Q5XGL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3