Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5XGG5

- CCNF_XENTR

UniProt

Q5XGG5 - CCNF_XENTR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cyclin-F

Gene

ccnf

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase.By similarity

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. negative regulation of centrosome duplication Source: UniProtKB
  3. protein ubiquitination Source: UniProtKB
  4. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-F
Gene namesi
Name:ccnf
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-963729. ccnf.

Subcellular locationi

Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
Note: Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Also localizes to the nucleus (By similarity).By similarity

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Cyclin-FPRO_0000398638Add
BLAST

Expressioni

Gene expression databases

BgeeiQ5XGG5.

Interactioni

Subunit structurei

Component of the SCF(CCNF) complex.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000027235.

Structurei

3D structure databases

ProteinModelPortaliQ5XGG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 7548F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini302 – 411110Cyclin N-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni589 – 747159PESTAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi19 – 279Nuclear localization signal 1By similarity
Motifi575 – 5817Nuclear localization signal 2By similarity

Domaini

The nuclear localization signals mediate the localization to the nucleus.By similarity

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated
Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00730000111208.
HOGENOMiHOG000285971.
HOVERGENiHBG050838.
InParanoidiQ5XGG5.
KOiK10289.
OMAiKSCLQCR.
OrthoDBiEOG7WDN1V.
TreeFamiTF101006.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
1.25.40.10. 2 hits.
InterProiIPR028857. CCNF_metazoan.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
IPR001810. F-box_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR10177:SF183. PTHR10177:SF183. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF00646. F-box. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XGG5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKGGALHCRC SKCFAAPPKR RVKRRPRVLT LLSLPEDVLL YVLECLPAVD
60 70 80 90 100
ILSMREVHPH LRSLVDSHSS VWARASFQDV WPSPENLNLF ERAAECGNFE
110 120 130 140 150
ACVKLGIAYL YNEGLSLSDD GRAEVNGLKA SRFFSLTERL NSGADPFVWL
160 170 180 190 200
FIRPPWSSSG SCCKAVVFDS LKEECGTVTS EEGATGALKG SIQYCLAKVL
210 220 230 240 250
SLFEDDDKKR EALGMLESSA SHGCLHSSYL LWETKQKTAL SDPGRYLQSF
260 270 280 290 300
RQLRDYAARG CWDAQISLAK ACGHKNQLSQ EQRSASELVN QVFQSSLPIN
310 320 330 340 350
KTSIFTTQKG MNDTMRYILI DWLVEVATMK DFSSLCLHMT VGLVDRYLKL
360 370 380 390 400
RSVPRAKLQL VGIACMVICT RFISKEILTI REAVWLTDNT YKYEDLVRMM
410 420 430 440 450
GEIISALEGK IRMPTVVDYK DVLSHLIPLD RSTLHLCSYI SELSLLYTEL
460 470 480 490 500
STYSPAQLAA GALLLARILH KQARPWPAQL AETTGFTLEH LTPCVVLLHK
510 520 530 540 550
KCFHDDAPKD YRQVSLTAVK QRFQDDLYDQ ISKEKVMDHS HLCELLGVPC
560 570 580 590 600
RDSESPASCP NAADFHQFLC SPSGSKTKRR REDSIQEDRG SFVTTPTAEL
610 620 630 640 650
SNQEEDLLGD FLDWSLETSC SGYEGDRESE GEREGEVTAP SGVLDLSLLI
660 670 680 690 700
TEHQQCQDTT SDDDSLVPLH PIPLLSKLEN GTHSTEGCAE KSSGYSSVSS
710 720 730 740 750
GGSPTSSSSP PGLPFTPTPG LNHSKLMPIP FPQPCSPLFK ASRRQVKRKN
760
QAQHSEDNLS DEL
Length:763
Mass (Da):84,864
Last modified:November 23, 2004 - v1
Checksum:iE9A52555CDDB22E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC084474 mRNA. Translation: AAH84474.1.
RefSeqiNP_001011083.1. NM_001011083.1.
UniGeneiStr.65893.

Genome annotation databases

EnsembliENSXETT00000027235; ENSXETP00000027235; ENSXETG00000012459.
GeneIDi496496.
KEGGixtr:496496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC084474 mRNA. Translation: AAH84474.1 .
RefSeqi NP_001011083.1. NM_001011083.1.
UniGenei Str.65893.

3D structure databases

ProteinModelPortali Q5XGG5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000027235.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000027235 ; ENSXETP00000027235 ; ENSXETG00000012459 .
GeneIDi 496496.
KEGGi xtr:496496.

Organism-specific databases

CTDi 899.
Xenbasei XB-GENE-963729. ccnf.

Phylogenomic databases

eggNOGi COG5024.
GeneTreei ENSGT00730000111208.
HOGENOMi HOG000285971.
HOVERGENi HBG050838.
InParanoidi Q5XGG5.
KOi K10289.
OMAi KSCLQCR.
OrthoDBi EOG7WDN1V.
TreeFami TF101006.

Gene expression databases

Bgeei Q5XGG5.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
1.25.40.10. 2 hits.
InterProi IPR028857. CCNF_metazoan.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
IPR001810. F-box_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
PANTHERi PTHR10177:SF183. PTHR10177:SF183. 1 hit.
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF00646. F-box. 1 hit.
[Graphical view ]
SMARTi SM00385. CYCLIN. 2 hits.
SM00256. FBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEi PS00292. CYCLINS. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiCCNF_XENTR
AccessioniPrimary (citable) accession number: Q5XGG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3