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Q5XGG5 (CCNF_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-F
Gene names
Name:ccnf
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length763 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase By similarity.

Subunit structure

Component of the SCF(CCNF) complex By similarity.

Subcellular location

Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity. Note: Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Also localizes to the nucleus By similarity.

Domain

The nuclear localization signals mediate the localization to the nucleus By similarity.

Sequence similarities

Belongs to the cyclin family. Cyclin AB subfamily.

Contains 1 cyclin N-terminal domain.

Contains 1 F-box domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 763763Cyclin-F
PRO_0000398638

Regions

Domain28 – 7548F-box
Domain302 – 411110Cyclin N-terminal
Region589 – 747159PEST
Motif19 – 279Nuclear localization signal 1 By similarity
Motif575 – 5817Nuclear localization signal 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5XGG5 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: E9A52555CDDB22E5

FASTA76384,864
        10         20         30         40         50         60 
MKGGALHCRC SKCFAAPPKR RVKRRPRVLT LLSLPEDVLL YVLECLPAVD ILSMREVHPH 

        70         80         90        100        110        120 
LRSLVDSHSS VWARASFQDV WPSPENLNLF ERAAECGNFE ACVKLGIAYL YNEGLSLSDD 

       130        140        150        160        170        180 
GRAEVNGLKA SRFFSLTERL NSGADPFVWL FIRPPWSSSG SCCKAVVFDS LKEECGTVTS 

       190        200        210        220        230        240 
EEGATGALKG SIQYCLAKVL SLFEDDDKKR EALGMLESSA SHGCLHSSYL LWETKQKTAL 

       250        260        270        280        290        300 
SDPGRYLQSF RQLRDYAARG CWDAQISLAK ACGHKNQLSQ EQRSASELVN QVFQSSLPIN 

       310        320        330        340        350        360 
KTSIFTTQKG MNDTMRYILI DWLVEVATMK DFSSLCLHMT VGLVDRYLKL RSVPRAKLQL 

       370        380        390        400        410        420 
VGIACMVICT RFISKEILTI REAVWLTDNT YKYEDLVRMM GEIISALEGK IRMPTVVDYK 

       430        440        450        460        470        480 
DVLSHLIPLD RSTLHLCSYI SELSLLYTEL STYSPAQLAA GALLLARILH KQARPWPAQL 

       490        500        510        520        530        540 
AETTGFTLEH LTPCVVLLHK KCFHDDAPKD YRQVSLTAVK QRFQDDLYDQ ISKEKVMDHS 

       550        560        570        580        590        600 
HLCELLGVPC RDSESPASCP NAADFHQFLC SPSGSKTKRR REDSIQEDRG SFVTTPTAEL 

       610        620        630        640        650        660 
SNQEEDLLGD FLDWSLETSC SGYEGDRESE GEREGEVTAP SGVLDLSLLI TEHQQCQDTT 

       670        680        690        700        710        720 
SDDDSLVPLH PIPLLSKLEN GTHSTEGCAE KSSGYSSVSS GGSPTSSSSP PGLPFTPTPG 

       730        740        750        760 
LNHSKLMPIP FPQPCSPLFK ASRRQVKRKN QAQHSEDNLS DEL 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC084474 mRNA. Translation: AAH84474.1.
RefSeqNP_001011083.1. NM_001011083.1.
UniGeneStr.65893.

3D structure databases

ProteinModelPortalQ5XGG5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000027235.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000027235; ENSXETP00000027235; ENSXETG00000012459.
GeneID496496.
KEGGxtr:496496.

Organism-specific databases

CTD899.
XenbaseXB-GENE-963729. ccnf.

Phylogenomic databases

eggNOGCOG5024.
GeneTreeENSGT00730000111208.
HOGENOMHOG000285971.
HOVERGENHBG050838.
InParanoidQ5XGG5.
KOK10289.
OMAKSCLQCR.
OrthoDBEOG7WDN1V.
TreeFamTF101006.

Gene expression databases

BgeeQ5XGG5.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
1.25.40.10. 2 hits.
InterProIPR028857. CCNF_metazoan.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
IPR001810. F-box_dom.
IPR011990. TPR-like_helical.
[Graphical view]
PANTHERPTHR10177:SF183. PTHR10177:SF183. 1 hit.
PfamPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF00646. F-box. 1 hit.
[Graphical view]
SMARTSM00385. CYCLIN. 2 hits.
SM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEPS00292. CYCLINS. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCNF_XENTR
AccessionPrimary (citable) accession number: Q5XGG5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families