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Q5XGG5

- CCNF_XENTR

UniProt

Q5XGG5 - CCNF_XENTR

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Protein
Cyclin-F
Gene
ccnf
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase By similarity.

GO - Biological processi

  1. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
  2. mitotic nuclear division Source: UniProtKB-KW
  3. negative regulation of centrosome duplication Source: UniProtKB
  4. protein ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-F
Gene namesi
Name:ccnf
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-963729. ccnf.

Subcellular locationi

Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
Note: Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Also localizes to the nucleus By similarity.

GO - Cellular componenti

  1. SCF ubiquitin ligase complex Source: UniProtKB
  2. centriole Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Cyclin-F
PRO_0000398638Add
BLAST

Expressioni

Gene expression databases

BgeeiQ5XGG5.

Interactioni

Subunit structurei

Component of the SCF(CCNF) complex By similarity.

Protein-protein interaction databases

STRINGi8364.ENSXETP00000027235.

Structurei

3D structure databases

ProteinModelPortaliQ5XGG5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 7548F-box
Add
BLAST
Domaini302 – 411110Cyclin N-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni589 – 747159PEST
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi19 – 279Nuclear localization signal 1 By similarity
Motifi575 – 5817Nuclear localization signal 2 By similarity

Domaini

The nuclear localization signals mediate the localization to the nucleus By similarity.

Sequence similaritiesi

Contains 1 F-box domain.

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00730000111208.
HOGENOMiHOG000285971.
HOVERGENiHBG050838.
InParanoidiQ5XGG5.
KOiK10289.
OMAiKSCLQCR.
OrthoDBiEOG7WDN1V.
TreeFamiTF101006.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
1.25.40.10. 2 hits.
InterProiIPR028857. CCNF_metazoan.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
IPR001810. F-box_dom.
IPR011990. TPR-like_helical.
[Graphical view]
PANTHERiPTHR10177:SF183. PTHR10177:SF183. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF00646. F-box. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XGG5-1 [UniParc]FASTAAdd to Basket

« Hide

MKGGALHCRC SKCFAAPPKR RVKRRPRVLT LLSLPEDVLL YVLECLPAVD    50
ILSMREVHPH LRSLVDSHSS VWARASFQDV WPSPENLNLF ERAAECGNFE 100
ACVKLGIAYL YNEGLSLSDD GRAEVNGLKA SRFFSLTERL NSGADPFVWL 150
FIRPPWSSSG SCCKAVVFDS LKEECGTVTS EEGATGALKG SIQYCLAKVL 200
SLFEDDDKKR EALGMLESSA SHGCLHSSYL LWETKQKTAL SDPGRYLQSF 250
RQLRDYAARG CWDAQISLAK ACGHKNQLSQ EQRSASELVN QVFQSSLPIN 300
KTSIFTTQKG MNDTMRYILI DWLVEVATMK DFSSLCLHMT VGLVDRYLKL 350
RSVPRAKLQL VGIACMVICT RFISKEILTI REAVWLTDNT YKYEDLVRMM 400
GEIISALEGK IRMPTVVDYK DVLSHLIPLD RSTLHLCSYI SELSLLYTEL 450
STYSPAQLAA GALLLARILH KQARPWPAQL AETTGFTLEH LTPCVVLLHK 500
KCFHDDAPKD YRQVSLTAVK QRFQDDLYDQ ISKEKVMDHS HLCELLGVPC 550
RDSESPASCP NAADFHQFLC SPSGSKTKRR REDSIQEDRG SFVTTPTAEL 600
SNQEEDLLGD FLDWSLETSC SGYEGDRESE GEREGEVTAP SGVLDLSLLI 650
TEHQQCQDTT SDDDSLVPLH PIPLLSKLEN GTHSTEGCAE KSSGYSSVSS 700
GGSPTSSSSP PGLPFTPTPG LNHSKLMPIP FPQPCSPLFK ASRRQVKRKN 750
QAQHSEDNLS DEL 763
Length:763
Mass (Da):84,864
Last modified:November 23, 2004 - v1
Checksum:iE9A52555CDDB22E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC084474 mRNA. Translation: AAH84474.1.
RefSeqiNP_001011083.1. NM_001011083.1.
UniGeneiStr.65893.

Genome annotation databases

EnsembliENSXETT00000027235; ENSXETP00000027235; ENSXETG00000012459.
GeneIDi496496.
KEGGixtr:496496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC084474 mRNA. Translation: AAH84474.1 .
RefSeqi NP_001011083.1. NM_001011083.1.
UniGenei Str.65893.

3D structure databases

ProteinModelPortali Q5XGG5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000027235.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000027235 ; ENSXETP00000027235 ; ENSXETG00000012459 .
GeneIDi 496496.
KEGGi xtr:496496.

Organism-specific databases

CTDi 899.
Xenbasei XB-GENE-963729. ccnf.

Phylogenomic databases

eggNOGi COG5024.
GeneTreei ENSGT00730000111208.
HOGENOMi HOG000285971.
HOVERGENi HBG050838.
InParanoidi Q5XGG5.
KOi K10289.
OMAi KSCLQCR.
OrthoDBi EOG7WDN1V.
TreeFami TF101006.

Gene expression databases

Bgeei Q5XGG5.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
1.25.40.10. 2 hits.
InterProi IPR028857. CCNF_metazoan.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
IPR001810. F-box_dom.
IPR011990. TPR-like_helical.
[Graphical view ]
PANTHERi PTHR10177:SF183. PTHR10177:SF183. 1 hit.
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF00646. F-box. 1 hit.
[Graphical view ]
SMARTi SM00385. CYCLIN. 2 hits.
SM00256. FBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEi PS00292. CYCLINS. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiCCNF_XENTR
AccessioniPrimary (citable) accession number: Q5XGG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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