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Q5XGG5

- CCNF_XENTR

UniProt

Q5XGG5 - CCNF_XENTR

Protein

Cyclin-F

Gene

ccnf

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase.By similarity

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. negative regulation of centrosome duplication Source: UniProtKB
    3. protein ubiquitination Source: UniProtKB
    4. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-F
    Gene namesi
    Name:ccnf
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-963729. ccnf.

    Subcellular locationi

    Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
    Note: Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Also localizes to the nucleus By similarity.By similarity

    GO - Cellular componenti

    1. centriole Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. SCF ubiquitin ligase complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 763763Cyclin-FPRO_0000398638Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ5XGG5.

    Interactioni

    Subunit structurei

    Component of the SCF(CCNF) complex.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000027235.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XGG5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 7548F-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini302 – 411110Cyclin N-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni589 – 747159PESTAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi19 – 279Nuclear localization signal 1By similarity
    Motifi575 – 5817Nuclear localization signal 2By similarity

    Domaini

    The nuclear localization signals mediate the localization to the nucleus.By similarity

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin AB subfamily.Curated
    Contains 1 cyclin N-terminal domain.Curated
    Contains 1 F-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5024.
    GeneTreeiENSGT00730000111208.
    HOGENOMiHOG000285971.
    HOVERGENiHBG050838.
    InParanoidiQ5XGG5.
    KOiK10289.
    OMAiKSCLQCR.
    OrthoDBiEOG7WDN1V.
    TreeFamiTF101006.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    1.25.40.10. 2 hits.
    InterProiIPR028857. CCNF_metazoan.
    IPR013763. Cyclin-like.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    IPR001810. F-box_dom.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PANTHERiPTHR10177:SF183. PTHR10177:SF183. 1 hit.
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    PF00646. F-box. 1 hit.
    [Graphical view]
    SMARTiSM00385. CYCLIN. 2 hits.
    SM00256. FBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    SSF81383. SSF81383. 1 hit.
    PROSITEiPS00292. CYCLINS. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5XGG5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGGALHCRC SKCFAAPPKR RVKRRPRVLT LLSLPEDVLL YVLECLPAVD    50
    ILSMREVHPH LRSLVDSHSS VWARASFQDV WPSPENLNLF ERAAECGNFE 100
    ACVKLGIAYL YNEGLSLSDD GRAEVNGLKA SRFFSLTERL NSGADPFVWL 150
    FIRPPWSSSG SCCKAVVFDS LKEECGTVTS EEGATGALKG SIQYCLAKVL 200
    SLFEDDDKKR EALGMLESSA SHGCLHSSYL LWETKQKTAL SDPGRYLQSF 250
    RQLRDYAARG CWDAQISLAK ACGHKNQLSQ EQRSASELVN QVFQSSLPIN 300
    KTSIFTTQKG MNDTMRYILI DWLVEVATMK DFSSLCLHMT VGLVDRYLKL 350
    RSVPRAKLQL VGIACMVICT RFISKEILTI REAVWLTDNT YKYEDLVRMM 400
    GEIISALEGK IRMPTVVDYK DVLSHLIPLD RSTLHLCSYI SELSLLYTEL 450
    STYSPAQLAA GALLLARILH KQARPWPAQL AETTGFTLEH LTPCVVLLHK 500
    KCFHDDAPKD YRQVSLTAVK QRFQDDLYDQ ISKEKVMDHS HLCELLGVPC 550
    RDSESPASCP NAADFHQFLC SPSGSKTKRR REDSIQEDRG SFVTTPTAEL 600
    SNQEEDLLGD FLDWSLETSC SGYEGDRESE GEREGEVTAP SGVLDLSLLI 650
    TEHQQCQDTT SDDDSLVPLH PIPLLSKLEN GTHSTEGCAE KSSGYSSVSS 700
    GGSPTSSSSP PGLPFTPTPG LNHSKLMPIP FPQPCSPLFK ASRRQVKRKN 750
    QAQHSEDNLS DEL 763
    Length:763
    Mass (Da):84,864
    Last modified:November 23, 2004 - v1
    Checksum:iE9A52555CDDB22E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC084474 mRNA. Translation: AAH84474.1.
    RefSeqiNP_001011083.1. NM_001011083.1.
    UniGeneiStr.65893.

    Genome annotation databases

    EnsembliENSXETT00000027235; ENSXETP00000027235; ENSXETG00000012459.
    GeneIDi496496.
    KEGGixtr:496496.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC084474 mRNA. Translation: AAH84474.1 .
    RefSeqi NP_001011083.1. NM_001011083.1.
    UniGenei Str.65893.

    3D structure databases

    ProteinModelPortali Q5XGG5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000027235.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000027235 ; ENSXETP00000027235 ; ENSXETG00000012459 .
    GeneIDi 496496.
    KEGGi xtr:496496.

    Organism-specific databases

    CTDi 899.
    Xenbasei XB-GENE-963729. ccnf.

    Phylogenomic databases

    eggNOGi COG5024.
    GeneTreei ENSGT00730000111208.
    HOGENOMi HOG000285971.
    HOVERGENi HBG050838.
    InParanoidi Q5XGG5.
    KOi K10289.
    OMAi KSCLQCR.
    OrthoDBi EOG7WDN1V.
    TreeFami TF101006.

    Gene expression databases

    Bgeei Q5XGG5.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    1.25.40.10. 2 hits.
    InterProi IPR028857. CCNF_metazoan.
    IPR013763. Cyclin-like.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    IPR001810. F-box_dom.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    PANTHERi PTHR10177:SF183. PTHR10177:SF183. 1 hit.
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    PF00646. F-box. 1 hit.
    [Graphical view ]
    SMARTi SM00385. CYCLIN. 2 hits.
    SM00256. FBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    SSF81383. SSF81383. 1 hit.
    PROSITEi PS00292. CYCLINS. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiCCNF_XENTR
    AccessioniPrimary (citable) accession number: Q5XGG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3