Q5XG92 (EST4A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carboxylesterase 4A
EC=3.1.1.-

Gene names

Name:	CES4A
Synonyms:	CES8
ORF Names:	UNQ440/PRO873

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	561 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable carboxylesterase By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the type-B carboxylesterase/lipase family.
Sequence caution	The sequence AAQ88868.1 differs from that shown. Reason: Chimeric cDNA. The sequence BAH12248.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Hydrolase Serine esterase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	carboxylesterase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5XG92-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Gene prediction based on similarity to mouse ortholog.

Isoform 2 (identifier: Q5XG92-2)

The sequence of this isoform differs from the canonical sequence as follows:
     361-387: Missing.
     439-481: Missing.

Note: No experimental confirmation available. Inactive.

Isoform 3 (identifier: Q5XG92-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-194: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 4 (identifier: Q5XG92-5)

The sequence of this isoform differs from the canonical sequence as follows:
     439-468: DAGLPVYLYEFEHHARGIIVKPRTDGADHG → ETPMMGICPAGHATTRMKSTCSWILPQEWA
     469-561: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q5XG92-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q5XG92-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.
     179-179: S → RWRGR
     439-468: DAGLPVYLYEFEHHARGIIVKPRTDGADHG → ETPMMGICPAGHATTRMKSTCSWILPQEWA
     469-561: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: Q5XG92-8)

The sequence of this isoform differs from the canonical sequence as follows:
     87-87: G → GWSLALSPGWSAVARSRLTATSASRVQASLLPQPLSVWGYR
     361-387: Missing.
     439-468: DAGLPVYLYEFEHHARGIIVKPRTDGADHG → ETPMMGICPAGHATTRMKSTCSWILPQEWA
     469-561: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 561	541	Carboxylesterase 4A		PRO_0000325923
Sites
	Active site	221	1	Acyl-ester intermediate By similarity
	Active site	353	1	Charge relay system By similarity
	Active site	467	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	214	1	N-linked (GlcNAc...) Potential
	Glycosylation	276	1	N-linked (GlcNAc...) Potential
	Glycosylation	388	1	N-linked (GlcNAc...) Potential
	Disulfide bond	88 ↔ 116		By similarity
	Disulfide bond	273 ↔ 284		By similarity
Natural variations
	Alternative sequence	1 – 194	194	Missing in isoform 3.		VSP_032480
	Alternative sequence	1 – 98	98	Missing in isoform 5 and isoform 6.		VSP_040063
	Alternative sequence	87	1	G → GWSLALSPGWSAVARSRLTA TSASRVQASLLPQPLSVWGY R in isoform 7.		VSP_040064
	Alternative sequence	179	1	S → RWRGR in isoform 6.		VSP_040065
	Alternative sequence	361 – 387	27	Missing in isoform 2 and isoform 7.		VSP_032483
	Alternative sequence	439 – 481	43	Missing in isoform 2.		VSP_032485
	Alternative sequence	439 – 468	30	DAGLP…GADHG → ETPMMGICPAGHATTRMKST CSWILPQEWA in isoform 4, isoform 6 and isoform 7.		VSP_040066
	Alternative sequence	469 – 561	93	Missing in isoform 4, isoform 6 and isoform 7.		VSP_040067
Experimental info
	Sequence conflict	254	1	L → P in BAC04422. Ref.1
	Sequence conflict	265	1	K → N in BAH12248. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: 27A4CFA5EBE0BC3A	FASTA	561	63,529
	10 20 30 40 50 60 MRWILCWSLT LCLMAQTALG ALHTKRPQVV TKYGTLQGKQ MHVGKTPIQV FLGVPFSRPP 70 80 90 100 110 120 LGILRFAPPE PPEPWKGIRD ATTYPPGCLQ ESWGQLASMY VSTRERYKWL RFSEDCLYLN 130 140 150 160 170 180 VYAPARAPGD PQLPVMVWFP GGAFIVGAAS SYEGSDLAAR EKVVLVFLQH RLGIFGFLST 190 200 210 220 230 240 DDSHARGNWG LLDQMAALRW VQENIAAFGG DPGNVTLFGQ SAGAMSISGL MMSPLASGLF 250 260 270 280 290 300 HRAISQSGTA LFRLFITSNP LKVAKKVAHL AGCNHNSTQI LVNCLRALSG TKVMRVSNKM 310 320 330 340 350 360 RFLQLNFQRD PEEIIWSMSP VVDGVVIPDD PLVLLTQGKV SSVPYLLGVN NLEFNWLLPY 370 380 390 400 410 420 IMKFPLNRQA MRKETITKML WSTRTLLNIT KEQVPLVVEE YLDNVNEHDW KMLRNRMMDI 430 440 450 460 470 480 VQDATFVYAT LQTAHYHRDA GLPVYLYEFE HHARGIIVKP RTDGADHGDE MYFLFGGPFA 490 500 510 520 530 540 TGLSMGKEKA LSLQMMKYWA NFARTGNPND GNLPCWPRYN KDEKYLQLDF TTRVGMKLKE 550 560 KKMAFWMSLY QSQRPEKQRQ F
	Isoform 2 [UniParc]. Checksum: BF4A69B04F0671C9	FASTA	491	55,445
	10 20 30 40 50 60 MRWILCWSLT LCLMAQTALG ALHTKRPQVV TKYGTLQGKQ MHVGKTPIQV FLGVPFSRPP 70 80 90 100 110 120 LGILRFAPPE PPEPWKGIRD ATTYPPGCLQ ESWGQLASMY VSTRERYKWL RFSEDCLYLN 130 140 150 160 170 180 VYAPARAPGD PQLPVMVWFP GGAFIVGAAS SYEGSDLAAR EKVVLVFLQH RLGIFGFLST 190 200 210 220 230 240 DDSHARGNWG LLDQMAALRW VQENIAAFGG DPGNVTLFGQ SAGAMSISGL MMSPLASGLF 250 260 270 280 290 300 HRAISQSGTA LFRLFITSNP LKVAKKVAHL AGCNHNSTQI LVNCLRALSG TKVMRVSNKM 310 320 330 340 350 360 RFLQLNFQRD PEEIIWSMSP VVDGVVIPDD PLVLLTQGKV SSVPYLLGVN NLEFNWLLPY 370 380 390 400 410 420 NITKEQVPLV VEEYLDNVNE HDWKMLRNRM MDIVQDATFV YATLQTAHYH RGLSMGKEKA 430 440 450 460 470 480 LSLQMMKYWA NFARTGNPND GNLPCWPRYN KDEKYLQLDF TTRVGMKLKE KKMAFWMSLY 490 QSQRPEKQRQ F
	Isoform 3 [UniParc]. Checksum: 85271A21B6B2FF65	FASTA	367	41,868
	10 20 30 40 50 60 MAALRWVQEN IAAFGGDPGN VTLFGQSAGA MSISGLMMSP LASGLFHRAI SQSGTALFRL 70 80 90 100 110 120 FITSNPLKVA KKVAHLAGCN HNSTQILVNC LRALSGTKVM RVSNKMRFLQ LNFQRDPEEI 130 140 150 160 170 180 IWSMSPVVDG VVIPDDPLVL LTQGKVSSVP YLLGVNNLEF NWLLPYIMKF PLNRQAMRKE 190 200 210 220 230 240 TITKMLWSTR TLLNITKEQV PLVVEEYLDN VNEHDWKMLR NRMMDIVQDA TFVYATLQTA 250 260 270 280 290 300 HYHRDAGLPV YLYEFEHHAR GIIVKPRTDG ADHGDEMYFL FGGPFATGLS MGKEKALSLQ 310 320 330 340 350 360 MMKYWANFAR TGNPNDGNLP CWPRYNKDEK YLQLDFTTRV GMKLKEKKMA FWMSLYQSQR PEKQRQF
	Isoform 4 [UniParc]. Checksum: 890EBC869CBF3414	FASTA	468	52,484
	10 20 30 40 50 60 MRWILCWSLT LCLMAQTALG ALHTKRPQVV TKYGTLQGKQ MHVGKTPIQV FLGVPFSRPP 70 80 90 100 110 120 LGILRFAPPE PPEPWKGIRD ATTYPPGCLQ ESWGQLASMY VSTRERYKWL RFSEDCLYLN 130 140 150 160 170 180 VYAPARAPGD PQLPVMVWFP GGAFIVGAAS SYEGSDLAAR EKVVLVFLQH RLGIFGFLST 190 200 210 220 230 240 DDSHARGNWG LLDQMAALRW VQENIAAFGG DPGNVTLFGQ SAGAMSISGL MMSPLASGLF 250 260 270 280 290 300 HRAISQSGTA LFRLFITSNP LKVAKKVAHL AGCNHNSTQI LVNCLRALSG TKVMRVSNKM 310 320 330 340 350 360 RFLQLNFQRD PEEIIWSMSP VVDGVVIPDD PLVLLTQGKV SSVPYLLGVN NLEFNWLLPY 370 380 390 400 410 420 IMKFPLNRQA MRKETITKML WSTRTLLNIT KEQVPLVVEE YLDNVNEHDW KMLRNRMMDI 430 440 450 460 VQDATFVYAT LQTAHYHRET PMMGICPAGH ATTRMKSTCS WILPQEWA
	Isoform 5 [UniParc]. Checksum: 9A0C691050DC8CCB	FASTA	463	52,649
	10 20 30 40 50 60 MYVSTRERYK WLRFSEDCLY LNVYAPARAP GDPQLPVMVW FPGGAFIVGA ASSYEGSDLA 70 80 90 100 110 120 AREKVVLVFL QHRLGIFGFL STDDSHARGN WGLLDQMAAL RWVQENIAAF GGDPGNVTLF 130 140 150 160 170 180 GQSAGAMSIS GLMMSPLASG LFHRAISQSG TALFRLFITS NPLKVAKKVA HLAGCNHNST 190 200 210 220 230 240 QILVNCLRAL SGTKVMRVSN KMRFLQLNFQ RDPEEIIWSM SPVVDGVVIP DDPLVLLTQG 250 260 270 280 290 300 KVSSVPYLLG VNNLEFNWLL PYIMKFPLNR QAMRKETITK MLWSTRTLLN ITKEQVPLVV 310 320 330 340 350 360 EEYLDNVNEH DWKMLRNRMM DIVQDATFVY ATLQTAHYHR DAGLPVYLYE FEHHARGIIV 370 380 390 400 410 420 KPRTDGADHG DEMYFLFGGP FATGLSMGKE KALSLQMMKY WANFARTGNP NDGNLPCWPR 430 440 450 460 YNKDEKYLQL DFTTRVGMKL KEKKMAFWMS LYQSQRPEKQ RQF
	Isoform 6 [UniParc]. Checksum: FC27F9D9DEA3C899	FASTA	374	42,229
	10 20 30 40 50 60 MYVSTRERYK WLRFSEDCLY LNVYAPARAP GDPQLPVMVW FPGGAFIVGA ASSYEGSDLA 70 80 90 100 110 120 AREKVVLVFL QHRLGIFGFL RWRGRTDDSH ARGNWGLLDQ MAALRWVQEN IAAFGGDPGN 130 140 150 160 170 180 VTLFGQSAGA MSISGLMMSP LASGLFHRAI SQSGTALFRL FITSNPLKVA KKVAHLAGCN 190 200 210 220 230 240 HNSTQILVNC LRALSGTKVM RVSNKMRFLQ LNFQRDPEEI IWSMSPVVDG VVIPDDPLVL 250 260 270 280 290 300 LTQGKVSSVP YLLGVNNLEF NWLLPYIMKF PLNRQAMRKE TITKMLWSTR TLLNITKEQV 310 320 330 340 350 360 PLVVEEYLDN VNEHDWKMLR NRMMDIVQDA TFVYATLQTA HYHRETPMMG ICPAGHATTR 370 MKSTCSWILP QEWA
	Isoform 7 [UniParc]. Checksum: DB8FB20E087A0E22	FASTA	481	53,504
	10 20 30 40 50 60 MRWILCWSLT LCLMAQTALG ALHTKRPQVV TKYGTLQGKQ MHVGKTPIQV FLGVPFSRPP 70 80 90 100 110 120 LGILRFAPPE PPEPWKGIRD ATTYPPGWSL ALSPGWSAVA RSRLTATSAS RVQASLLPQP 130 140 150 160 170 180 LSVWGYRCLQ ESWGQLASMY VSTRERYKWL RFSEDCLYLN VYAPARAPGD PQLPVMVWFP 190 200 210 220 230 240 GGAFIVGAAS SYEGSDLAAR EKVVLVFLQH RLGIFGFLST DDSHARGNWG LLDQMAALRW 250 260 270 280 290 300 VQENIAAFGG DPGNVTLFGQ SAGAMSISGL MMSPLASGLF HRAISQSGTA LFRLFITSNP 310 320 330 340 350 360 LKVAKKVAHL AGCNHNSTQI LVNCLRALSG TKVMRVSNKM RFLQLNFQRD PEEIIWSMSP 370 380 390 400 410 420 VVDGVVIPDD PLVLLTQGKV SSVPYLLGVN NLEFNWLLPY NITKEQVPLV VEEYLDNVNE 430 440 450 460 470 480 HDWKMLRNRM MDIVQDATFV YATLQTAHYH RETPMMGICP AGHATTRMKS TCSWILPQEW A

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4; 5 AND 6). Tissue: Hippocampus, Neuroepithelioma, Thalamus and Uterus.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-561 (ISOFORM 7).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-561 (ISOFORM 2). Tissue: Blood.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK094783 mRNA. Translation: BAC04422.1. AK293061 mRNA. Translation: BAF85750.1. AK295483 mRNA. Translation: BAH12085.1. AK296064 mRNA. Translation: BAH12248.1. Different initiation. AK300792 mRNA. Translation: BAH13349.1. AC009084 Genomic DNA. No translation available. AY358504 mRNA. Translation: AAQ88868.1. Sequence problems. BC084555 mRNA. Translation: AAH84555.1.
IPI	IPI00167706. IPI00411985. IPI00640345. IPI00872564. IPI00971162. IPI00973041. IPI00973352.
RefSeq	NP_001177130.1. NM_001190201.1. NP_001177131.1. NM_001190202.1. NP_776176.5. NM_173815.6.
UniGene	Hs.346947. Hs.734986.
3D structure databases
ProteinModelPortal	Q5XG92.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000381397.
Protein family/group databases
MEROPS	S09.959.
Polymorphism databases
DMDM	172045957.
Proteomic databases
PaxDb	Q5XG92.
PRIDE	Q5XG92.
Protocols and materials databases
DNASU	283848.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326686; ENSP00000314145; ENSG00000172824. ENST00000398354; ENSP00000381397; ENSG00000172824. ENST00000535696; ENSP00000441644; ENSG00000172824. ENST00000538199; ENSP00000441103; ENSG00000172824. ENST00000540579; ENSP00000441907; ENSG00000172824. ENST00000540947; ENSP00000444052; ENSG00000172824.
GeneID	283848.
KEGG	hsa:283848.
UCSC	uc002eqw.3. human. uc002eqx.3. human. uc010vix.2. human. uc010viy.2. human.
Organism-specific databases
CTD	283848.
GeneCards	GC16P067023.
HGNC	HGNC:26741. CES4A.
HPA	HPA035701.
neXtProt	NX_Q5XG92.
PharmGKB	PA164717904.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2272.
HOVERGEN	HBG008839.
OMA	NNAMARR.
OrthoDB	EOG4M91R4.
Gene expression databases
ArrayExpress	Q5XG92.
Bgee	Q5XG92.
Genevestigator	Q5XG92.
Family and domain databases
InterPro	IPR002018. CarbesteraseB. IPR019826. Carboxylesterase_B_AS. IPR019819. Carboxylesterase_B_CS. [Graphical view]
Pfam	PF00135. COesterase. 1 hit. [Graphical view]
PROSITE	PS00122. CARBOXYLESTERASE_B_1. 1 hit. PS00941. CARBOXYLESTERASE_B_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CES4A. human.
GenomeRNAi	283848.
NextBio	94282.

Entry information

Entry name

EST4A_HUMAN

Accession

Primary (citable) accession number: Q5XG92
Secondary accession number(s): A8KAJ6 , B7Z349, B7Z3L2, B7Z6R3, Q6UX55, Q8N9F4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	May 29, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.