Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acyl-CoA-binding domain-containing protein 5

Gene

Acbd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101Acyl-CoABy similarity1
Binding sitei120Acyl-CoABy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-390918. Peroxisomal lipid metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 5
Gene namesi
Name:Acbd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1921409. Acbd5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei480 – 500HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002873781 – 508Acyl-CoA-binding domain-containing protein 5Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineCombined sources1
Modified residuei185PhosphoserineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei206PhosphoserineBy similarity1
Modified residuei233PhosphoserineCombined sources1
Modified residuei303PhosphoserineBy similarity1
Modified residuei405PhosphoserineBy similarity1
Modified residuei446N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XG73.
PRIDEiQ5XG73.

PTM databases

iPTMnetiQ5XG73.
PhosphoSitePlusiQ5XG73.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026781.
CleanExiMM_ACBD5.
ExpressionAtlasiQ5XG73. baseline and differential.
GenevisibleiQ5XG73. MM.

Interactioni

Protein-protein interaction databases

IntActiQ5XG73. 2 interactors.
MINTiMINT-4116316.
STRINGi10090.ENSMUSP00000110175.

Structurei

3D structure databases

ProteinModelPortaliQ5XG73.
SMRiQ5XG73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 133ACBPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni55 – 64Acyl-CoA bindingBy similarity10
Regioni75 – 79Acyl-CoA bindingBy similarity5

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili181 – 214Sequence analysisAdd BLAST34
Coiled coili428 – 453Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 19Poly-Cys5
Compositional biasi502 – 505Poly-Arg4

Sequence similaritiesi

Belongs to the ATG37 family.Curated
Contains 1 ACB (acyl-CoA-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
GeneTreeiENSGT00840000129776.
HOVERGENiHBG106445.
InParanoidiQ5XG73.
PhylomeDBiQ5XG73.
TreeFamiTF319446.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR016347. ACBD5.
IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PIRSFiPIRSF002412. MA_DBI. 1 hit.
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5XG73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFLAFHAGS WGSWCCCCCV ITADRPWDRG RRWQLEMADT PSVYETRFEA
60 70 80 90 100
AVKVIQSLPK NGSFQPTNEM MLKFYSFYKQ ATEGPCKLSR PGFWDPIGRY
110 120 130 140 150
KWDAWSSLGD MTKEEAMIAY VEEMKKIIET MPMTEKVEEL LHVIGPFYEI
160 170 180 190 200
VEDKKSSKSS DLTSDLGNVL TSSNAKAVNG KAESSDSGAE SEEEEAQEEL
210 220 230 240 250
KGAEQSGSDD KKTLKKSADK NLEIIVTNGY KGSFVQDIQS DIHTDSSRST
260 270 280 290 300
RSSEDEKPGD ESSQQTGHTI VCAHQDRNED PSEDASGIHH LTSDSDSEVY
310 320 330 340 350
CDSMEQFGQE EYYLGGDPTQ HLESSGFCED AQQSPGNGSI GKMWMVAVKG
360 370 380 390 400
KGEVKHGGED GRSSSGAPHR ETRGGESEDF SSVRRGRGNR IPHLSEGPKG
410 420 430 440 450
RQVGSGGDGE RWGSDRGSRG SLNEQIALVL IRLQEDMQNV LQRLHKLETL
460 470 480 490 500
TASQAKLSLQ TSNQPSSQRP AWWPFEMSPG ALAFAIIWPF IAQWLAHLYY

QRRRRKLN
Length:508
Mass (Da):56,614
Last modified:November 23, 2004 - v1
Checksum:iB8345C43231DDAA8
GO
Isoform 2 (identifier: Q5XG73-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:472
Mass (Da):52,370
Checksum:iB11C6A1BAE4D3099
GO
Isoform 3 (identifier: Q5XG73-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     387-387: R → RV

Show »
Length:473
Mass (Da):52,469
Checksum:i6D4CDBA24AD04DD6
GO

Sequence cautioni

The sequence AAH35202 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH53518 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0254501 – 36Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_025451387R → RV in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005001 mRNA. Translation: BAB23735.2.
AK050450 mRNA. Translation: BAC34262.1.
AK147839 mRNA. Translation: BAE28174.1.
AL845257 Genomic DNA. Translation: CAM19533.1.
AL845257 Genomic DNA. Translation: CAM19534.1.
AL845257 Genomic DNA. Translation: CAM19535.1.
AL845257 Genomic DNA. Translation: CAM19536.1.
BC035202 mRNA. Translation: AAH35202.1. Different initiation.
BC053518 mRNA. Translation: AAH53518.1. Different initiation.
BC061484 mRNA. Translation: AAH61484.2.
BC084584 mRNA. Translation: AAH84584.1.
CCDSiCCDS50514.1. [Q5XG73-1]
CCDS50515.1. [Q5XG73-3]
CCDS50516.1. [Q5XG73-2]
RefSeqiNP_001095906.1. NM_001102436.1. [Q5XG73-2]
NP_001095907.1. NM_001102437.1.
NP_001095908.1. NM_001102438.1. [Q5XG73-1]
NP_083069.1. NM_028793.3. [Q5XG73-3]
UniGeneiMm.181973.
Mm.439111.

Genome annotation databases

EnsembliENSMUST00000028121; ENSMUSP00000028121; ENSMUSG00000026781. [Q5XG73-2]
ENSMUST00000114523; ENSMUSP00000110169; ENSMUSG00000026781. [Q5XG73-3]
ENSMUST00000114526; ENSMUSP00000110172; ENSMUSG00000026781. [Q5XG73-1]
GeneIDi74159.
KEGGimmu:74159.
UCSCiuc008inx.1. mouse. [Q5XG73-1]
uc008iny.1. mouse. [Q5XG73-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005001 mRNA. Translation: BAB23735.2.
AK050450 mRNA. Translation: BAC34262.1.
AK147839 mRNA. Translation: BAE28174.1.
AL845257 Genomic DNA. Translation: CAM19533.1.
AL845257 Genomic DNA. Translation: CAM19534.1.
AL845257 Genomic DNA. Translation: CAM19535.1.
AL845257 Genomic DNA. Translation: CAM19536.1.
BC035202 mRNA. Translation: AAH35202.1. Different initiation.
BC053518 mRNA. Translation: AAH53518.1. Different initiation.
BC061484 mRNA. Translation: AAH61484.2.
BC084584 mRNA. Translation: AAH84584.1.
CCDSiCCDS50514.1. [Q5XG73-1]
CCDS50515.1. [Q5XG73-3]
CCDS50516.1. [Q5XG73-2]
RefSeqiNP_001095906.1. NM_001102436.1. [Q5XG73-2]
NP_001095907.1. NM_001102437.1.
NP_001095908.1. NM_001102438.1. [Q5XG73-1]
NP_083069.1. NM_028793.3. [Q5XG73-3]
UniGeneiMm.181973.
Mm.439111.

3D structure databases

ProteinModelPortaliQ5XG73.
SMRiQ5XG73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5XG73. 2 interactors.
MINTiMINT-4116316.
STRINGi10090.ENSMUSP00000110175.

PTM databases

iPTMnetiQ5XG73.
PhosphoSitePlusiQ5XG73.

Proteomic databases

PaxDbiQ5XG73.
PRIDEiQ5XG73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028121; ENSMUSP00000028121; ENSMUSG00000026781. [Q5XG73-2]
ENSMUST00000114523; ENSMUSP00000110169; ENSMUSG00000026781. [Q5XG73-3]
ENSMUST00000114526; ENSMUSP00000110172; ENSMUSG00000026781. [Q5XG73-1]
GeneIDi74159.
KEGGimmu:74159.
UCSCiuc008inx.1. mouse. [Q5XG73-1]
uc008iny.1. mouse. [Q5XG73-3]

Organism-specific databases

CTDi91452.
MGIiMGI:1921409. Acbd5.

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
GeneTreeiENSGT00840000129776.
HOVERGENiHBG106445.
InParanoidiQ5XG73.
PhylomeDBiQ5XG73.
TreeFamiTF319446.

Enzyme and pathway databases

ReactomeiR-MMU-390918. Peroxisomal lipid metabolism.

Miscellaneous databases

PROiQ5XG73.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026781.
CleanExiMM_ACBD5.
ExpressionAtlasiQ5XG73. baseline and differential.
GenevisibleiQ5XG73. MM.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR016347. ACBD5.
IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PIRSFiPIRSF002412. MA_DBI. 1 hit.
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACBD5_MOUSE
AccessioniPrimary (citable) accession number: Q5XG73
Secondary accession number(s): A2AQX9
, A2AQY0, Q6P7V7, Q7TSC2, Q8BKU6, Q8CI99, Q9CW41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.