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Protein

RNA polymerase II elongation factor ELL3

Gene

Ell3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II elongation factor ELL3
Gene namesi
Name:Ell3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1309917. Ell3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004217671 – 387RNA polymerase II elongation factor ELL3Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei240PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XFX8.
PRIDEiQ5XFX8.

PTM databases

iPTMnetiQ5XFX8.
PhosphoSitePlusiQ5XFX8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000022868.

Interactioni

Subunit structurei

Interacts with AFF4. Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031619.

Structurei

3D structure databases

ProteinModelPortaliQ5XFX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELL/occludin family.Curated

Phylogenomic databases

eggNOGiKOG4796. Eukaryota.
ENOG410ZNGU. LUCA.
GeneTreeiENSGT00550000074378.
HOGENOMiHOG000231840.
HOVERGENiHBG051462.
InParanoidiQ5XFX8.
KOiK15183.
OMAiLTIWAAM.
OrthoDBiEOG091G043D.
PhylomeDBiQ5XFX8.
TreeFamiTF337345.

Family and domain databases

InterProiIPR031176. ELL/occludin.
IPR031175. ELL3.
IPR019464. ELL_N.
IPR010844. Occludin_ELL.
[Graphical view]
PANTHERiPTHR23288. PTHR23288. 1 hit.
PTHR23288:SF18. PTHR23288:SF18. 1 hit.
PfamiPF10390. ELL. 1 hit.
PF07303. Occludin_ELL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XFX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGTQEALSG KMRLLFTPAA RTSLLMLRLN EAALRALQEC QQQQVRPVIA
60 70 80 90 100
FQGQRGYLRL PGPGWSCLFS FIVSQCGQEG GGLDLVYQRL GRSGPNCLHC
110 120 130 140 150
LGSLRERLTI WAAMDTIPAP LLAQEHLTEG TRESESWQDS EDEPEGHPQM
160 170 180 190 200
ALQEVSDPLA SNHEQSLPGS SSEPMAQWEV RNHTYLSNRE PDQPLPSSAS
210 220 230 240 250
QKRLDKKRSA PITTEEPEEK RPRALPLASS PLQGLSNQDS PEEQDWGQDA
260 270 280 290 300
DGDSRLEQSL SVQSASESPS PEEVPDYLLQ YSTIHSAEQQ QAYEQDFETD
310 320 330 340 350
YAEYRILHAR VGAASQRFTE LGAEIKRLQR GTPEHKVLED KIVQEYKKFR
360 370 380
KRYPSYSEEK RRCEYLHEKL SHIKGLILEF EEKNRGS
Length:387
Mass (Da):43,803
Last modified:November 23, 2004 - v1
Checksum:i9A2BCF8A71DA4920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097745 Genomic DNA. No translation available.
BC084693 mRNA. Translation: AAH84693.1.
RefSeqiNP_001011957.1. NM_001011957.1.
UniGeneiRn.162689.

Genome annotation databases

EnsembliENSRNOT00000036823; ENSRNOP00000031619; ENSRNOG00000022868.
GeneIDi296102.
KEGGirno:296102.
UCSCiRGD:1309917. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097745 Genomic DNA. No translation available.
BC084693 mRNA. Translation: AAH84693.1.
RefSeqiNP_001011957.1. NM_001011957.1.
UniGeneiRn.162689.

3D structure databases

ProteinModelPortaliQ5XFX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031619.

PTM databases

iPTMnetiQ5XFX8.
PhosphoSitePlusiQ5XFX8.

Proteomic databases

PaxDbiQ5XFX8.
PRIDEiQ5XFX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036823; ENSRNOP00000031619; ENSRNOG00000022868.
GeneIDi296102.
KEGGirno:296102.
UCSCiRGD:1309917. rat.

Organism-specific databases

CTDi80237.
RGDi1309917. Ell3.

Phylogenomic databases

eggNOGiKOG4796. Eukaryota.
ENOG410ZNGU. LUCA.
GeneTreeiENSGT00550000074378.
HOGENOMiHOG000231840.
HOVERGENiHBG051462.
InParanoidiQ5XFX8.
KOiK15183.
OMAiLTIWAAM.
OrthoDBiEOG091G043D.
PhylomeDBiQ5XFX8.
TreeFamiTF337345.

Enzyme and pathway databases

ReactomeiR-RNO-6807505. RNA polymerase II transcribes snRNA genes.

Miscellaneous databases

PROiQ5XFX8.

Gene expression databases

BgeeiENSRNOG00000022868.

Family and domain databases

InterProiIPR031176. ELL/occludin.
IPR031175. ELL3.
IPR019464. ELL_N.
IPR010844. Occludin_ELL.
[Graphical view]
PANTHERiPTHR23288. PTHR23288. 1 hit.
PTHR23288:SF18. PTHR23288:SF18. 1 hit.
PfamiPF10390. ELL. 1 hit.
PF07303. Occludin_ELL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELL3_RAT
AccessioniPrimary (citable) accession number: Q5XFX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.