Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA polymerase II elongation factor ELL3

Gene

Ell3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II elongation factor ELL3
Gene namesi
Name:Ell3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1309917 Ell3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004217671 – 387RNA polymerase II elongation factor ELL3Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei240PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XFX8
PRIDEiQ5XFX8

PTM databases

iPTMnetiQ5XFX8
PhosphoSitePlusiQ5XFX8

Expressioni

Gene expression databases

BgeeiENSRNOG00000022868

Interactioni

Subunit structurei

Interacts with AFF4. Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031619

Structurei

3D structure databases

ProteinModelPortaliQ5XFX8
SMRiQ5XFX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELL/occludin family.Curated

Phylogenomic databases

eggNOGiKOG4796 Eukaryota
ENOG410ZNGU LUCA
GeneTreeiENSGT00550000074378
HOGENOMiHOG000231840
HOVERGENiHBG051462
InParanoidiQ5XFX8
KOiK15183
OMAiHAYEQDF
OrthoDBiEOG091G043D
PhylomeDBiQ5XFX8
TreeFamiTF337345

Family and domain databases

InterProiView protein in InterPro
IPR031176 ELL/occludin
IPR031175 ELL3
IPR019464 ELL_N
IPR010844 Occludin_ELL
PANTHERiPTHR23288 PTHR23288, 1 hit
PTHR23288:SF18 PTHR23288:SF18, 1 hit
PfamiView protein in Pfam
PF10390 ELL, 1 hit
PF07303 Occludin_ELL, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XFX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGTQEALSG KMRLLFTPAA RTSLLMLRLN EAALRALQEC QQQQVRPVIA
60 70 80 90 100
FQGQRGYLRL PGPGWSCLFS FIVSQCGQEG GGLDLVYQRL GRSGPNCLHC
110 120 130 140 150
LGSLRERLTI WAAMDTIPAP LLAQEHLTEG TRESESWQDS EDEPEGHPQM
160 170 180 190 200
ALQEVSDPLA SNHEQSLPGS SSEPMAQWEV RNHTYLSNRE PDQPLPSSAS
210 220 230 240 250
QKRLDKKRSA PITTEEPEEK RPRALPLASS PLQGLSNQDS PEEQDWGQDA
260 270 280 290 300
DGDSRLEQSL SVQSASESPS PEEVPDYLLQ YSTIHSAEQQ QAYEQDFETD
310 320 330 340 350
YAEYRILHAR VGAASQRFTE LGAEIKRLQR GTPEHKVLED KIVQEYKKFR
360 370 380
KRYPSYSEEK RRCEYLHEKL SHIKGLILEF EEKNRGS
Length:387
Mass (Da):43,803
Last modified:November 23, 2004 - v1
Checksum:i9A2BCF8A71DA4920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097745 Genomic DNA No translation available.
BC084693 mRNA Translation: AAH84693.1
RefSeqiNP_001011957.1, NM_001011957.1
UniGeneiRn.162689

Genome annotation databases

EnsembliENSRNOT00000036823; ENSRNOP00000031619; ENSRNOG00000022868
GeneIDi296102
KEGGirno:296102
UCSCiRGD:1309917 rat

Similar proteinsi

Entry informationi

Entry nameiELL3_RAT
AccessioniPrimary (citable) accession number: Q5XFX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome