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Protein

Transgelin-2

Gene

Tagln2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin-2
Gene namesi
Name:Tagln2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1310840. Tagln2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003559912 – 199Transgelin-2Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei17N6-acetyllysineBy similarity1
Modified residuei20N6-acetyllysineBy similarity1
Modified residuei163PhosphoserineCombined sources1
Modified residuei180PhosphothreonineBy similarity1
Modified residuei182Omega-N-methylarginineBy similarity1
Modified residuei196Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XFX0.
PRIDEiQ5XFX0.

PTM databases

iPTMnetiQ5XFX0.
PhosphoSitePlusiQ5XFX0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008301.
GenevisibleiQ5XFX0. RN.

Interactioni

Protein-protein interaction databases

IntActiQ5XFX0. 1 interactor.
STRINGi10116.ENSRNOP00000011208.

Structurei

3D structure databases

ProteinModelPortaliQ5XFX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 136CHPROSITE-ProRule annotationAdd BLAST113
Repeati174 – 199Calponin-likeAdd BLAST26

Sequence similaritiesi

Belongs to the calponin family.Curated
Contains 1 calponin-like repeat.PROSITE-ProRule annotation
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiQ5XFX0.
KOiK20526.
OMAiFRMANRG.
OrthoDBiEOG091G0LY2.
PhylomeDBiQ5XFX0.
TreeFamiTF313921.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XFX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANRGPSYGL SREVQQKIEK QYDPDLEQIL IQWITTQCRK GVSQPQPGRE
60 70 80 90 100
NFQNWLKDGT VLCELINSLY PEGQAPVKKI QASTMAFKQM EQISQFLQAA
110 120 130 140 150
ERYGINTTDI FQTVDLWEGK NMACVQRTLM NLGGLAVARD DGLFSGDPNW
160 170 180 190
FPKKSKENPR NFSDNQLQEG KNVIGLQMGT NRGASQAGMT GYGMPRQIL
Length:199
Mass (Da):22,393
Last modified:November 23, 2004 - v1
Checksum:i5BDAAA283E4BDDEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084703 mRNA. Translation: AAH84703.1.
RefSeqiNP_001013145.1. NM_001013127.1.
XP_006250357.1. XM_006250295.2.
UniGeneiRn.104497.

Genome annotation databases

EnsembliENSRNOT00000011208; ENSRNOP00000011208; ENSRNOG00000008301.
GeneIDi304983.
KEGGirno:304983.
UCSCiRGD:1310840. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084703 mRNA. Translation: AAH84703.1.
RefSeqiNP_001013145.1. NM_001013127.1.
XP_006250357.1. XM_006250295.2.
UniGeneiRn.104497.

3D structure databases

ProteinModelPortaliQ5XFX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5XFX0. 1 interactor.
STRINGi10116.ENSRNOP00000011208.

PTM databases

iPTMnetiQ5XFX0.
PhosphoSitePlusiQ5XFX0.

Proteomic databases

PaxDbiQ5XFX0.
PRIDEiQ5XFX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011208; ENSRNOP00000011208; ENSRNOG00000008301.
GeneIDi304983.
KEGGirno:304983.
UCSCiRGD:1310840. rat.

Organism-specific databases

CTDi8407.
RGDi1310840. Tagln2.

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiQ5XFX0.
KOiK20526.
OMAiFRMANRG.
OrthoDBiEOG091G0LY2.
PhylomeDBiQ5XFX0.
TreeFamiTF313921.

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Miscellaneous databases

PROiQ5XFX0.

Gene expression databases

BgeeiENSRNOG00000008301.
GenevisibleiQ5XFX0. RN.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAGL2_RAT
AccessioniPrimary (citable) accession number: Q5XFX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: November 23, 2004
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.