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Q5XFW8

- SEC13_RAT

UniProt

Q5XFW8 - SEC13_RAT

Protein

Protein SEC13 homolog

Gene

Sec13

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles By similarity. As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway By similarity.By similarity

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: MGI
    2. mRNA transport Source: UniProtKB-KW
    3. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, mRNA transport, Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_194781. Separation of Sister Chromatids.
    REACT_198611. Resolution of Sister Chromatid Cohesion.
    REACT_198830. MHC class II antigen presentation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SEC13 homolog
    Alternative name(s):
    SEC13-like protein 1
    Gene namesi
    Name:Sec13
    Synonyms:Sec13l1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi1359555. Sec13.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. ER to Golgi transport vesicle membrane Source: UniProtKB-SubCell
    3. nuclear pore outer ring Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 322321Protein SEC13 homologPRO_0000281770Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylvalineBy similarity
    Modified residuei309 – 3091PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ5XFW8.
    PRIDEiQ5XFW8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5XFW8.

    Interactioni

    Subunit structurei

    At the nuclear pore: component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13 By similarity. At the COPII coat complex: interacts with SEC31A and SEC31B. Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers By similarity.By similarity

    Protein-protein interaction databases

    MINTiMINT-4577232.
    STRINGi10116.ENSRNOP00000014377.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XFW8.
    SMRiQ5XFW8. Positions 14-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 5040WD 1Add
    BLAST
    Repeati55 – 9642WD 2Add
    BLAST
    Repeati101 – 14444WD 3Add
    BLAST
    Repeati148 – 20457WD 4Add
    BLAST
    Repeati210 – 25344WD 5Add
    BLAST
    Repeati260 – 29940WD 6Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat SEC13 family.Curated
    Contains 6 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00550000075049.
    HOGENOMiHOG000216895.
    HOVERGENiHBG057343.
    InParanoidiQ5XFW8.
    KOiK14004.
    OMAiRACAGKD.
    OrthoDBiEOG7966GP.
    PhylomeDBiQ5XFW8.
    TreeFamiTF300815.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 6 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 6 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5XFW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI    50
    ADLRGHEGPV WQVAWAHPMY GNILASCSYD RKVIIWKEEN GTWEKTHEHS 100
    GHDSSVNSVC WAPHDYGLIL ACGSSDGAIS LLTYTGEGQW EVKKINNAHT 150
    IGCNAVSWAP AVVPGSLIDQ PSGQKPNYIK KFASGGCDNL IKLWREEEDG 200
    QWKEEQKLEA HSDWVRDVAW APSIGLPTST IASCSQDGRV FIWTCDDASG 250
    NMWSPKLLHK FNDVVWHVSW SITANILAVS GGDNKVTLWK ESVDGQWVCI 300
    SDVNKGQGSV SASITEGQQN EQ 322
    Length:322
    Mass (Da):35,548
    Last modified:November 23, 2004 - v1
    Checksum:i24F54AB8C7131985
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC084705 mRNA. Translation: AAH84705.1.
    RefSeqiNP_001006979.1. NM_001006978.1.
    UniGeneiRn.1553.

    Genome annotation databases

    EnsembliENSRNOT00000014377; ENSRNOP00000014377; ENSRNOG00000010628.
    GeneIDi297522.
    KEGGirno:297522.
    UCSCiRGD:1359555. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC084705 mRNA. Translation: AAH84705.1 .
    RefSeqi NP_001006979.1. NM_001006978.1.
    UniGenei Rn.1553.

    3D structure databases

    ProteinModelPortali Q5XFW8.
    SMRi Q5XFW8. Positions 14-304.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4577232.
    STRINGi 10116.ENSRNOP00000014377.

    Proteomic databases

    PaxDbi Q5XFW8.
    PRIDEi Q5XFW8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000014377 ; ENSRNOP00000014377 ; ENSRNOG00000010628 .
    GeneIDi 297522.
    KEGGi rno:297522.
    UCSCi RGD:1359555. rat.

    Organism-specific databases

    CTDi 6396.
    RGDi 1359555. Sec13.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00550000075049.
    HOGENOMi HOG000216895.
    HOVERGENi HBG057343.
    InParanoidi Q5XFW8.
    KOi K14004.
    OMAi RACAGKD.
    OrthoDBi EOG7966GP.
    PhylomeDBi Q5XFW8.
    TreeFami TF300815.

    Enzyme and pathway databases

    Reactomei REACT_194781. Separation of Sister Chromatids.
    REACT_198611. Resolution of Sister Chromatid Cohesion.
    REACT_198830. MHC class II antigen presentation.

    Miscellaneous databases

    NextBioi 642376.
    PROi Q5XFW8.

    Gene expression databases

    Genevestigatori Q5XFW8.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 6 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 6 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    2. "Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport."
      Tang B.L., Zhang T., Low D.Y.H., Wong E.T., Horstmann H., Hong W.
      J. Biol. Chem. 275:13597-13604(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SEC31A.

    Entry informationi

    Entry nameiSEC13_RAT
    AccessioniPrimary (citable) accession number: Q5XFW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3