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Q5XFW8 (SEC13_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein SEC13 homolog
Alternative name(s):
SEC13-like protein 1
Gene names
Name:Sec13
Synonyms:Sec13l1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles By similarity. As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway By similarity.

Subunit structure

At the nuclear pore: component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13 By similarity. At the COPII coat complex: interacts with SEC31A and SEC31B. Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers By similarity. Ref.2

Subcellular location

Cytoplasmic vesicleCOPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleusnuclear pore complex. Note: In interphase, localizes at both sides of the NPC By similarity.

Sequence similarities

Belongs to the WD repeat SEC13 family.

Contains 6 WD repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 322321Protein SEC13 homolog
PRO_0000281770

Regions

Repeat11 – 5040WD 1
Repeat55 – 9642WD 2
Repeat101 – 14444WD 3
Repeat148 – 20457WD 4
Repeat210 – 25344WD 5
Repeat260 – 29940WD 6

Amino acid modifications

Modified residue21N-acetylvaline By similarity
Modified residue3091Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5XFW8 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 24F54AB8C7131985

FASTA32235,548
        10         20         30         40         50         60 
MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI ADLRGHEGPV 

        70         80         90        100        110        120 
WQVAWAHPMY GNILASCSYD RKVIIWKEEN GTWEKTHEHS GHDSSVNSVC WAPHDYGLIL 

       130        140        150        160        170        180 
ACGSSDGAIS LLTYTGEGQW EVKKINNAHT IGCNAVSWAP AVVPGSLIDQ PSGQKPNYIK 

       190        200        210        220        230        240 
KFASGGCDNL IKLWREEEDG QWKEEQKLEA HSDWVRDVAW APSIGLPTST IASCSQDGRV 

       250        260        270        280        290        300 
FIWTCDDASG NMWSPKLLHK FNDVVWHVSW SITANILAVS GGDNKVTLWK ESVDGQWVCI 

       310        320 
SDVNKGQGSV SASITEGQQN EQ 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[2]"Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport."
Tang B.L., Zhang T., Low D.Y.H., Wong E.T., Horstmann H., Hong W.
J. Biol. Chem. 275:13597-13604(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SEC31A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC084705 mRNA. Translation: AAH84705.1.
RefSeqNP_001006979.1. NM_001006978.1.
UniGeneRn.1553.

3D structure databases

ProteinModelPortalQ5XFW8.
SMRQ5XFW8. Positions 14-304.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4577232.
STRING10116.ENSRNOP00000014377.

Proteomic databases

PaxDbQ5XFW8.
PRIDEQ5XFW8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000014377; ENSRNOP00000014377; ENSRNOG00000010628.
GeneID297522.
KEGGrno:297522.
UCSCRGD:1359555. rat.

Organism-specific databases

CTD6396.
RGD1359555. Sec13.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00550000075049.
HOGENOMHOG000216895.
HOVERGENHBG057343.
InParanoidQ5XFW8.
KOK14004.
OMAGEWECVK.
OrthoDBEOG7966GP.
PhylomeDBQ5XFW8.
TreeFamTF300815.

Gene expression databases

GenevestigatorQ5XFW8.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 6 hits.
[Graphical view]
SMARTSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio642376.
PROQ5XFW8.

Entry information

Entry nameSEC13_RAT
AccessionPrimary (citable) accession number: Q5XFW8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families