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Q5XFW8

- SEC13_RAT

UniProt

Q5XFW8 - SEC13_RAT

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Protein
Protein SEC13 homolog
Gene
Sec13, Sec13l1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles By similarity. As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway By similarity.

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: MGI
  2. mRNA transport Source: UniProtKB-KW
  3. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_194781. Separation of Sister Chromatids.
REACT_198611. Resolution of Sister Chromatid Cohesion.
REACT_198830. MHC class II antigen presentation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SEC13 homolog
Alternative name(s):
SEC13-like protein 1
Gene namesi
Name:Sec13
Synonyms:Sec13l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1359555. Sec13.

Subcellular locationi

GO - Cellular componenti

  1. ER to Golgi transport vesicle membrane Source: UniProtKB-SubCell
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. nuclear pore outer ring Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 322321Protein SEC13 homolog
PRO_0000281770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylvaline By similarity
Modified residuei309 – 3091Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XFW8.
PRIDEiQ5XFW8.

Expressioni

Gene expression databases

GenevestigatoriQ5XFW8.

Interactioni

Subunit structurei

At the nuclear pore: component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13 By similarity. At the COPII coat complex: interacts with SEC31A and SEC31B. Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers By similarity.1 Publication

Protein-protein interaction databases

MINTiMINT-4577232.
STRINGi10116.ENSRNOP00000014377.

Structurei

3D structure databases

ProteinModelPortaliQ5XFW8.
SMRiQ5XFW8. Positions 14-304.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 5040WD 1
Add
BLAST
Repeati55 – 9642WD 2
Add
BLAST
Repeati101 – 14444WD 3
Add
BLAST
Repeati148 – 20457WD 4
Add
BLAST
Repeati210 – 25344WD 5
Add
BLAST
Repeati260 – 29940WD 6
Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat SEC13 family.
Contains 6 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00550000075049.
HOGENOMiHOG000216895.
HOVERGENiHBG057343.
InParanoidiQ5XFW8.
KOiK14004.
OMAiRACAGKD.
OrthoDBiEOG7966GP.
PhylomeDBiQ5XFW8.
TreeFamiTF300815.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 6 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XFW8-1 [UniParc]FASTAAdd to Basket

« Hide

MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI    50
ADLRGHEGPV WQVAWAHPMY GNILASCSYD RKVIIWKEEN GTWEKTHEHS 100
GHDSSVNSVC WAPHDYGLIL ACGSSDGAIS LLTYTGEGQW EVKKINNAHT 150
IGCNAVSWAP AVVPGSLIDQ PSGQKPNYIK KFASGGCDNL IKLWREEEDG 200
QWKEEQKLEA HSDWVRDVAW APSIGLPTST IASCSQDGRV FIWTCDDASG 250
NMWSPKLLHK FNDVVWHVSW SITANILAVS GGDNKVTLWK ESVDGQWVCI 300
SDVNKGQGSV SASITEGQQN EQ 322
Length:322
Mass (Da):35,548
Last modified:November 23, 2004 - v1
Checksum:i24F54AB8C7131985
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC084705 mRNA. Translation: AAH84705.1.
RefSeqiNP_001006979.1. NM_001006978.1.
UniGeneiRn.1553.

Genome annotation databases

EnsembliENSRNOT00000014377; ENSRNOP00000014377; ENSRNOG00000010628.
GeneIDi297522.
KEGGirno:297522.
UCSCiRGD:1359555. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC084705 mRNA. Translation: AAH84705.1 .
RefSeqi NP_001006979.1. NM_001006978.1.
UniGenei Rn.1553.

3D structure databases

ProteinModelPortali Q5XFW8.
SMRi Q5XFW8. Positions 14-304.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-4577232.
STRINGi 10116.ENSRNOP00000014377.

Proteomic databases

PaxDbi Q5XFW8.
PRIDEi Q5XFW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000014377 ; ENSRNOP00000014377 ; ENSRNOG00000010628 .
GeneIDi 297522.
KEGGi rno:297522.
UCSCi RGD:1359555. rat.

Organism-specific databases

CTDi 6396.
RGDi 1359555. Sec13.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00550000075049.
HOGENOMi HOG000216895.
HOVERGENi HBG057343.
InParanoidi Q5XFW8.
KOi K14004.
OMAi RACAGKD.
OrthoDBi EOG7966GP.
PhylomeDBi Q5XFW8.
TreeFami TF300815.

Enzyme and pathway databases

Reactomei REACT_194781. Separation of Sister Chromatids.
REACT_198611. Resolution of Sister Chromatid Cohesion.
REACT_198830. MHC class II antigen presentation.

Miscellaneous databases

NextBioi 642376.
PROi Q5XFW8.

Gene expression databases

Genevestigatori Q5XFW8.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 6 hits.
[Graphical view ]
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  2. "Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport."
    Tang B.L., Zhang T., Low D.Y.H., Wong E.T., Horstmann H., Hong W.
    J. Biol. Chem. 275:13597-13604(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SEC31A.

Entry informationi

Entry nameiSEC13_RAT
AccessioniPrimary (citable) accession number: Q5XFW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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