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Q5XFW8

- SEC13_RAT

UniProt

Q5XFW8 - SEC13_RAT

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Protein

Protein SEC13 homolog

Gene

Sec13

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway (By similarity).By similarity

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: MGI
  2. mRNA transport Source: UniProtKB-KW
  3. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_194781. Separation of Sister Chromatids.
REACT_198611. Resolution of Sister Chromatid Cohesion.
REACT_198830. MHC class II antigen presentation.
REACT_245819. Mitotic Prometaphase.
REACT_247598. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
REACT_261016. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SEC13 homolog
Alternative name(s):
SEC13-like protein 1
Gene namesi
Name:Sec13
Synonyms:Sec13l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1359555. Sec13.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. endoplasmic reticulum Source: UniProtKB-KW
  3. nuclear pore outer ring Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 322321Protein SEC13 homologPRO_0000281770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylvalineBy similarity
Modified residuei309 – 3091PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XFW8.
PRIDEiQ5XFW8.

Expressioni

Gene expression databases

GenevestigatoriQ5XFW8.

Interactioni

Subunit structurei

At the nuclear pore: component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13 (By similarity). At the COPII coat complex: interacts with SEC31A and SEC31B. Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-4577232.
STRINGi10116.ENSRNOP00000014377.

Structurei

3D structure databases

ProteinModelPortaliQ5XFW8.
SMRiQ5XFW8. Positions 14-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 5040WD 1Add
BLAST
Repeati55 – 9642WD 2Add
BLAST
Repeati101 – 14444WD 3Add
BLAST
Repeati148 – 20457WD 4Add
BLAST
Repeati210 – 25344WD 5Add
BLAST
Repeati260 – 29940WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat SEC13 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00550000075049.
HOGENOMiHOG000216895.
HOVERGENiHBG057343.
InParanoidiQ5XFW8.
KOiK14004.
OMAiRACAGKD.
OrthoDBiEOG7966GP.
PhylomeDBiQ5XFW8.
TreeFamiTF300815.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 6 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XFW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI
60 70 80 90 100
ADLRGHEGPV WQVAWAHPMY GNILASCSYD RKVIIWKEEN GTWEKTHEHS
110 120 130 140 150
GHDSSVNSVC WAPHDYGLIL ACGSSDGAIS LLTYTGEGQW EVKKINNAHT
160 170 180 190 200
IGCNAVSWAP AVVPGSLIDQ PSGQKPNYIK KFASGGCDNL IKLWREEEDG
210 220 230 240 250
QWKEEQKLEA HSDWVRDVAW APSIGLPTST IASCSQDGRV FIWTCDDASG
260 270 280 290 300
NMWSPKLLHK FNDVVWHVSW SITANILAVS GGDNKVTLWK ESVDGQWVCI
310 320
SDVNKGQGSV SASITEGQQN EQ
Length:322
Mass (Da):35,548
Last modified:November 23, 2004 - v1
Checksum:i24F54AB8C7131985
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084705 mRNA. Translation: AAH84705.1.
RefSeqiNP_001006979.1. NM_001006978.1.
UniGeneiRn.1553.

Genome annotation databases

EnsembliENSRNOT00000014377; ENSRNOP00000014377; ENSRNOG00000010628.
GeneIDi297522.
KEGGirno:297522.
UCSCiRGD:1359555. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084705 mRNA. Translation: AAH84705.1 .
RefSeqi NP_001006979.1. NM_001006978.1.
UniGenei Rn.1553.

3D structure databases

ProteinModelPortali Q5XFW8.
SMRi Q5XFW8. Positions 14-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4577232.
STRINGi 10116.ENSRNOP00000014377.

Proteomic databases

PaxDbi Q5XFW8.
PRIDEi Q5XFW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000014377 ; ENSRNOP00000014377 ; ENSRNOG00000010628 .
GeneIDi 297522.
KEGGi rno:297522.
UCSCi RGD:1359555. rat.

Organism-specific databases

CTDi 6396.
RGDi 1359555. Sec13.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00550000075049.
HOGENOMi HOG000216895.
HOVERGENi HBG057343.
InParanoidi Q5XFW8.
KOi K14004.
OMAi RACAGKD.
OrthoDBi EOG7966GP.
PhylomeDBi Q5XFW8.
TreeFami TF300815.

Enzyme and pathway databases

Reactomei REACT_194781. Separation of Sister Chromatids.
REACT_198611. Resolution of Sister Chromatid Cohesion.
REACT_198830. MHC class II antigen presentation.
REACT_245819. Mitotic Prometaphase.
REACT_247598. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
REACT_261016. COPII (Coat Protein 2) Mediated Vesicle Transport.

Miscellaneous databases

NextBioi 642376.
PROi Q5XFW8.

Gene expression databases

Genevestigatori Q5XFW8.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 6 hits.
[Graphical view ]
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  2. "Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport."
    Tang B.L., Zhang T., Low D.Y.H., Wong E.T., Horstmann H., Hong W.
    J. Biol. Chem. 275:13597-13604(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SEC31A.

Entry informationi

Entry nameiSEC13_RAT
AccessioniPrimary (citable) accession number: Q5XFW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3