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Protein

Mitochondrial mRNA pseudouridine synthase Trub2

Gene

Trub2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Minor enzyme contributing to the conversion of uridine to pseudouridine (PSI) at position 390 in mitochondrial COXI (MT-CO1) mRNA and at position 697-699 in mitochondrial COXIII (MT-CO3) mRNA, modulating the efficiency of mitochondrial protein synthesis without changes in transcript abundance or stability.By similarity

Catalytic activityi

tRNA uridine = tRNA pseudouridine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei98NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processmRNA processing, tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial mRNA pseudouridine synthase Trub2 (EC:5.4.99.-)
Gene namesi
Name:Trub2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1359394 Trub2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000252092? – 323Mitochondrial mRNA pseudouridine synthase Trub2
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ5XFW2
PRIDEiQ5XFW2

Expressioni

Gene expression databases

BgeeiENSRNOG00000043189
GenevisibleiQ5XFW2 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063203

Structurei

3D structure databases

ProteinModelPortaliQ5XFW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2559 Eukaryota
ENOG4110V1W LUCA
GeneTreeiENSGT00530000063611
HOVERGENiHBG053337
InParanoidiQ5XFW2
OMAiLIRPMNK
OrthoDBiEOG091G0FSQ
PhylomeDBiQ5XFW2

Family and domain databases

InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR002501 PsdUridine_synth_N
PfamiView protein in Pfam
PF01509 TruB_N, 1 hit
SUPFAMiSSF55120 SSF55120, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XFW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSGLARLQ GLFAVYKPPG LKWLHVRETV ELQLLKGLNA QQPSAPEQHV
60 70 80 90 100
RFLLGPVEGS EEKKLTLTAT SVPSLTTHRL VRGPAFRNLK IGVGHRLDVQ
110 120 130 140 150
ASGVLVLAVG HGRSLLTDMY DAHLTKDYTV RGLLGKATDN FCEDGQLIEK
160 170 180 190 200
TTYDHVTRER LDRILAMIQG SHQKALVMYS NLDLKSQEAY ERAVQGVIRP
210 220 230 240 250
MNKSPMLIAG IRCLHFAPPE FLLEVQCMHE TQQQLRRLVH EIGLELKTTA
260 270 280 290 300
VCMQVRRTRD GFFGLDDALL RTQWDLHSIQ DAIQTAAPRV ARELRKNLSL
310 320
MSGHQQQLPS AGQPWASRVQ APL
Length:323
Mass (Da):36,109
Last modified:November 23, 2004 - v1
Checksum:i74C46218FD68A22F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084712 mRNA Translation: AAH84712.1
RefSeqiNP_001014279.1, NM_001014257.2
UniGeneiRn.105581

Genome annotation databases

EnsembliENSRNOT00000064638; ENSRNOP00000063203; ENSRNOG00000043189
GeneIDi366012
KEGGirno:366012

Similar proteinsi

Entry informationi

Entry nameiTRUB2_RAT
AccessioniPrimary (citable) accession number: Q5XFW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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