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Protein

Probable tRNA pseudouridine synthase 2

Gene

Trub2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be responsible for synthesis of pseudouridine from uracil in transfer RNAs.By similarity

Catalytic activityi

tRNA uridine = tRNA pseudouridine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase 2 (EC:5.4.99.-)
Gene namesi
Name:Trub2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1359394. Trub2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Probable tRNA pseudouridine synthase 2PRO_0000252092Add
BLAST

Proteomic databases

PaxDbiQ5XFW2.
PRIDEiQ5XFW2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000043189.
GenevisibleiQ5XFW2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063203.

Structurei

3D structure databases

ProteinModelPortaliQ5XFW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family.Curated

Phylogenomic databases

eggNOGiKOG2559. Eukaryota.
ENOG4110V1W. LUCA.
GeneTreeiENSGT00530000063611.
HOVERGENiHBG053337.
InParanoidiQ5XFW2.
OMAiHGCRLLT.
OrthoDBiEOG091G0FSQ.
PhylomeDBiQ5XFW2.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
[Graphical view]
PfamiPF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5XFW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSGLARLQ GLFAVYKPPG LKWLHVRETV ELQLLKGLNA QQPSAPEQHV
60 70 80 90 100
RFLLGPVEGS EEKKLTLTAT SVPSLTTHRL VRGPAFRNLK IGVGHRLDVQ
110 120 130 140 150
ASGVLVLAVG HGRSLLTDMY DAHLTKDYTV RGLLGKATDN FCEDGQLIEK
160 170 180 190 200
TTYDHVTRER LDRILAMIQG SHQKALVMYS NLDLKSQEAY ERAVQGVIRP
210 220 230 240 250
MNKSPMLIAG IRCLHFAPPE FLLEVQCMHE TQQQLRRLVH EIGLELKTTA
260 270 280 290 300
VCMQVRRTRD GFFGLDDALL RTQWDLHSIQ DAIQTAAPRV ARELRKNLSL
310 320
MSGHQQQLPS AGQPWASRVQ APL
Length:323
Mass (Da):36,109
Last modified:November 23, 2004 - v1
Checksum:i74C46218FD68A22F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084712 mRNA. Translation: AAH84712.1.
RefSeqiNP_001014279.1. NM_001014257.2.
UniGeneiRn.105581.

Genome annotation databases

EnsembliENSRNOT00000064638; ENSRNOP00000063203; ENSRNOG00000043189.
GeneIDi366012.
KEGGirno:366012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084712 mRNA. Translation: AAH84712.1.
RefSeqiNP_001014279.1. NM_001014257.2.
UniGeneiRn.105581.

3D structure databases

ProteinModelPortaliQ5XFW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063203.

Proteomic databases

PaxDbiQ5XFW2.
PRIDEiQ5XFW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000064638; ENSRNOP00000063203; ENSRNOG00000043189.
GeneIDi366012.
KEGGirno:366012.

Organism-specific databases

CTDi26995.
RGDi1359394. Trub2.

Phylogenomic databases

eggNOGiKOG2559. Eukaryota.
ENOG4110V1W. LUCA.
GeneTreeiENSGT00530000063611.
HOVERGENiHBG053337.
InParanoidiQ5XFW2.
OMAiHGCRLLT.
OrthoDBiEOG091G0FSQ.
PhylomeDBiQ5XFW2.

Miscellaneous databases

PROiQ5XFW2.

Gene expression databases

BgeeiENSRNOG00000043189.
GenevisibleiQ5XFW2. RN.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
[Graphical view]
PfamiPF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiTRUB2_RAT
AccessioniPrimary (citable) accession number: Q5XFW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.