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Q5XF89 (AT133_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable cation-transporting ATPase 13A3
EC=3.6.3.-
Gene names
Name:Atp13a3
Synonyms:Gm542
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1219 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + H2O = ADP + phosphate.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expression is greatest in liver, followed by kidney, colon, stomach, brain and small intestine. Isoform 1 is highly expressed in the kidney while isoform 2 is highly expressed in the brain. Ref.1

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionHydrolase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processATP catabolic process

Inferred from electronic annotation. Source: GOC

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

cation-transporting ATPase activity

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5XF89-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5XF89-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1154-1154: E → ESFFLDTVLWKVVFNRDKQGECRFSTTQPPQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12191219Probable cation-transporting ATPase 13A3
PRO_0000363358

Regions

Transmembrane29 – 4921Helical; Potential
Transmembrane202 – 22221Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane406 – 42621Helical; Potential
Transmembrane445 – 46521Helical; Potential
Transmembrane937 – 95721Helical; Potential
Transmembrane959 – 97921Helical; Potential
Transmembrane996 – 101621Helical; Potential
Transmembrane1067 – 108721Helical; Potential
Transmembrane1099 – 111921Helical; Potential
Transmembrane1137 – 115721Helical; Potential
Compositional bias227 – 2304Poly-Tyr

Sites

Active site49414-aspartylphosphate intermediate By similarity
Metal binding8791Magnesium By similarity
Metal binding8831Magnesium By similarity

Amino acid modifications

Modified residue8131Phosphoserine Ref.2

Natural variations

Alternative sequence11541E → ESFFLDTVLWKVVFNRDKQG ECRFSTTQPPQ in isoform 2.
VSP_036301

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 186F60AE9CEAA82E

FASTA1,219137,469
        10         20         30         40         50         60 
MDKEERKTIN KGQEDEMEIH GYNLCRWKLA MVFVGVICTG GFLLLLLYWL PEWRVKATCV 

        70         80         90        100        110        120 
RAAVKDCEVV LLRTTDEFRV WFCAKIHFLP VENQPNLNAK CLVNEVSNGH AVHLTEENRC 

       130        140        150        160        170        180 
EMNKYSQSQS QQMRYFTHHS IRYFWNDAIH NFDFLKGLDE GVSCASLYEK HSAGLTQGMH 

       190        200        210        220        230        240 
AYRKLIYGVN EIAVKVPSVF KLLIKEVLNP FYIFQLFSVI LWSVDEYYYY ALAIVIMSVV 

       250        260        270        280        290        300 
SIISSLYSIR KQYVMLHDMV ATHSTVRVSV CRENEEIEEI FSTDLVPGDV MIIPLNGTVM 

       310        320        330        340        350        360 
PCDAVLINGT CIVNESMLTG ESVPVTKTNL PNPSVDVKGM GEEQYSPETH KRHTLFCGTT 

       370        380        390        400        410        420 
VIQTRFYTGE LVKAIVVRTG FSTSKGQLVR SILYPKPTDF KLYRDAYLFL LCLVVVAGIG 

       430        440        450        460        470        480 
FIYTIINSIL NEKEVQEIII KSLDIITITV PPALPAAMTA GIVYAQRRLK KVGIFCISPQ 

       490        500        510        520        530        540 
RINICGQLNL VCFDKTGTLT EDGLDLWGIQ RVENTRFLLP EDNVCSEMLV KSQFVACMAT 

       550        560        570        580        590        600 
CHSLTKIEGV LSGDPLDLKM FEAIGWILEE ATEEETALHN RIMPTVVRPS KQLLPEPTTA 

       610        620        630        640        650        660 
GNQEMELFEL PAIYEIGIVR QFPFSSALQR MSVVARTLGE KRMDAYMKGA PEVVASLCKP 

       670        680        690        700        710        720 
ETVPVDFEKV LEDYTKQGFR VIALAHRKLE SKLTWHKVQH ISRDAIENNM DFMGLIIMQN 

       730        740        750        760        770        780 
KLKQETPAVL EDLHKANIRT VMVTGDNMLT AVSVARDCGM ILPQDKVIIA EALPPKDGKV 

       790        800        810        820        830        840 
AKINWHYTDS LSQCSESSAI DSEAIPIKLA HDSLEDLEVT RYHFAMNGKS FSVILEHFQD 

       850        860        870        880        890        900 
LVPKLMLHGT VFARMAPDQK TQLVEALQNV DYFVGMCGDG ANDCGALKRA HGGISLSELE 

       910        920        930        940        950        960 
ASVASPFTSK TPSISCVPNL IREGRAALMT SFCVFKFMAL YSIIQYFSVT LLYSILSNLG 

       970        980        990       1000       1010       1020 
DFQFLFIDLA IILVVVFTMS LNPAWKELVA QRPPSGLISG ALLFSVLSQI VISVGFQSLG 

      1030       1040       1050       1060       1070       1080 
FFWVKQYKVC DPNSDVCNTT RSACWNSSHL YNGTELDSCK IQNYENTTVF FISSFQYLTV 

      1090       1100       1110       1120       1130       1140 
AVAFSKGKPF RQPCYKNYFF VISVIILYVF ILFIMLHPVA SVDQVLEIMC VPYQWRIYML 

      1150       1160       1170       1180       1190       1200 
IIVLINAFVS ITVEESVDRW GKCCLSWALS CRKKTPKAKY MYLAQELRFD PEWPPKPQTT 

      1210 
TEAKAVVKEN GSCQIITIA

« Hide

Isoform 2 [UniParc].

Checksum: 95A4E38B0CEE89FF
Show »

FASTA1,249141,026

References

« Hide 'large scale' references
[1]"Characterization of the P5 subfamily of P-type transport ATPases in mice."
Schultheis P.J., Hagen T.T., O'Toole K.K., Tachibana A., Burke C.R., McGill D.L., Okunade G.W., Shull G.E.
Biochem. Biophys. Res. Commun. 323:731-738(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[2]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-813, MASS SPECTROMETRY.
Tissue: Macrophage.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BK005558 mRNA. Translation: DAA05589.1.
IPIIPI00665580.
IPI00850873.
RefSeqNP_001121566.1. NM_001128094.1.
NP_001121568.1. NM_001128096.1.
UniGeneMm.8924.

3D structure databases

ProteinModelPortalQ5XF89.
SMRQ5XF89. Positions 174-760, 852-1008.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000051645.

PTM databases

PhosphoSiteQ5XF89.

Proteomic databases

PaxDbQ5XF89.
PRIDEQ5XF89.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000061350; ENSMUSP00000051645; ENSMUSG00000022533.
ENSMUST00000100013; ENSMUSP00000128224; ENSMUSG00000022533.
GeneID224088.
KEGGmmu:224088.
UCSCuc012aee.1. mouse.
uc012aef.1. mouse.

Organism-specific databases

CTD79572.
MGIMGI:2685387. Atp13a3.

Phylogenomic databases

eggNOGCOG0474.
GeneTreeENSGT00530000063001.
HOGENOMHOG000171813.
HOVERGENHBG065757.
InParanoidQ5XF89.
KOK14951.
OMAVVVFTMS.
OrthoDBEOG45HRWM.

Gene expression databases

BgeeQ5XF89.
GenevestigatorQ5XF89.

Family and domain databases

Gene3D2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProIPR004014. ATPase_P-typ_cation-transptr_N.
IPR006544. ATPase_P-typ_Cation_typ_V.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PANTHERPTHR24093. PTHR24093. 1 hit.
PfamPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF81660. ATPase_cation_domN. 1 hit.
SSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSATP13A3. mouse.
NextBio377055.
SOURCESearch...

Entry information

Entry nameAT133_MOUSE
AccessionPrimary (citable) accession number: Q5XF89
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: November 23, 2004
Last modified: May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents