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Q5XEL0 (KPRS1_STRP6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase 1
Short name=RPPK 1
EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase 1
Short name=P-Rib-PP synthase 1
Short name=PRPP synthase 1
Gene names
Name:prs1
Ordered Locus Names:M6_Spy0018
OrganismStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) [Complete proteome] [HAMAP]
Taxonomic identifier286636 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00583

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP-Rule MF_00583

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence caution

The sequence AAT86153.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Ribose-phosphate pyrophosphokinase 1 HAMAP-Rule MF_00583
PRO_0000141212

Regions

Region217 – 23014Binding of phosphoribosylpyrophosphate Potential

Sites

Metal binding1301Magnesium Potential
Metal binding1321Magnesium Potential
Metal binding1411Magnesium Potential
Metal binding1451Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
Q5XEL0 [UniParc].

Last modified August 30, 2005. Version 2.
Checksum: 8DD79296FCABD695

FASTA32035,044
        10         20         30         40         50         60 
MSYSDLKLFA LSSNKELAEK VASAMGIQLG KSTVRQFSDG EIQVNIEESI RGHHVFILQS 

        70         80         90        100        110        120 
TSSPVNDNLM EILIMVDALK RASAEKISVV MPYYGYARQD RKARSREPIT SKLVANMLEV 

       130        140        150        160        170        180 
AGVDRLLTVD LHAAQIQGFF DIPVDHLMGA PLIADYFDRH GLVGEDVVVV SPDHGGVTRA 

       190        200        210        220        230        240 
RKLAQFLQTP IAIIDKRRSV DKMNTSEVMN IIGNVSGKKC ILIDDMIDTA GTICHAADAL 

       250        260        270        280        290        300 
AEAGATAVYA SCTHPVLSGP ALDNIQRSAI EKLIVLDTIY LPKERLIDKI EQISIADLVA 

       310        320 
EAIIRIHEKR PLSPLFEMGN

« Hide

References

[1]"Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain."
Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.
J. Infect. Dis. 190:727-738(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-946 / MGAS10394.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000003 Genomic DNA. Translation: AAT86153.1. Different initiation.
RefSeqYP_059336.1. NC_006086.1.

3D structure databases

ProteinModelPortalQ5XEL0.
SMRQ5XEL0. Positions 5-316.
ModBaseSearch...

Protein-protein interaction databases

STRING286636.M6_Spy0018.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT86153; AAT86153; M6_Spy0018.
GeneID2942146.
KEGGspa:M6_Spy0018.
PATRIC19722094. VBIStrPyo30273_0019.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0462.
HOGENOMHOG000210449.
KOK00948.
OMAYVQIQES.
ProtClustDBPRK02269.

Enzyme and pathway databases

UniPathwayUPA00087; UER00172.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase_dom.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. ribP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPRS1_STRP6
AccessionPrimary (citable) accession number: Q5XEL0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: May 1, 2013
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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