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Q5XE09

- G6PI_STRP6

UniProt

Q5XE09 - G6PI_STRP6

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei291 – 2911Proton donorUniRule annotation
    Active sitei312 – 3121UniRule annotation
    Active sitei426 – 4261UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciSPYO286636:GHNO-269-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Ordered Locus Names:M6_Spy0219
    OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
    Taxonomic identifieri286636 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001167: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Glucose-6-phosphate isomerasePRO_0000180744Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi286636.M6_Spy0219.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XE09.
    SMRiQ5XE09. Positions 3-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000100403.
    KOiK01810.
    OMAiLANFNPK.
    OrthoDBiEOG64R61J.

    Family and domain databases

    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5XE09-1 [UniParc]FASTAAdd to Basket

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    MSHITFDYSK VLESFAGQHE IDFLQGQVTE ADKLLREGTG PGSDFLGWLD    50
    LPENYDKEEF ARILTAAEKI KADSEVLVVI GIGGSYLGAK AAIDFLNHHF 100
    ANLQTAKERK APQILYAGNS ISSTYLADLV EYVQDKEFSV NVISKSGTTT 150
    EPAIAFRVFK ELLVKKYGQE EANKRIYATT DKVKGAVKVE ADANNWETFV 200
    VPDNVGGRFS VLTAVGLLPI AASGADITAL MEGANAARKD LSSDKISENI 250
    AYQYAAVRNV LYRKGYITEI LANYEPSLQY LGEWWKQLAG ESEGKDQKGI 300
    YPTSANFSTD LHSLGQFIQE GYRNLFETVI RVDNPRKNVI IPELAEDLDG 350
    LGYLQGKDVD FVNKKATDGV LLAHTDGGVP NMFVTLPAQD EFTLGYTIYF 400
    FELAIAVSGY MNAVNPFDQP GVEAYKRNMF ALLGKPGFEA LSAELNARL 449
    Length:449
    Mass (Da):49,433
    Last modified:November 23, 2004 - v1
    Checksum:i84E6139B3793BC7A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000003 Genomic DNA. Translation: AAT86354.1.
    RefSeqiYP_059537.1. NC_006086.1.

    Genome annotation databases

    EnsemblBacteriaiAAT86354; AAT86354; M6_Spy0219.
    GeneIDi2942010.
    KEGGispa:M6_Spy0219.
    PATRICi19722533. VBIStrPyo30273_0222.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000003 Genomic DNA. Translation: AAT86354.1 .
    RefSeqi YP_059537.1. NC_006086.1.

    3D structure databases

    ProteinModelPortali Q5XE09.
    SMRi Q5XE09. Positions 3-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 286636.M6_Spy0219.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT86354 ; AAT86354 ; M6_Spy0219 .
    GeneIDi 2942010.
    KEGGi spa:M6_Spy0219.
    PATRICi 19722533. VBIStrPyo30273_0222.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000100403.
    KOi K01810.
    OMAi LANFNPK.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci SPYO286636:GHNO-269-MONOMER.

    Family and domain databases

    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain."
      Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.
      J. Infect. Dis. 190:727-738(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-946 / MGAS10394.

    Entry informationi

    Entry nameiG6PI_STRP6
    AccessioniPrimary (citable) accession number: Q5XE09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3