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Protein

UTP--glucose-1-phosphate uridylyltransferase 1

Gene

hasC1

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi

GO - Molecular functioni

  1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. biosynthetic process Source: InterPro
  2. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

BioCyciSPYO286636:GHNO-274-MONOMER.
UniPathwayiUPA00215.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase 1 (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase 1
UDP-glucose pyrophosphorylase 1
Short name:
UDPGP 1
Uridine diphosphoglucose pyrophosphorylase 1
Gene namesi
Name:hasC1
Synonyms:hasC
Ordered Locus Names:M6_Spy0224
OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Taxonomic identifieri286636 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001167: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299UTP--glucose-1-phosphate uridylyltransferase 1PRO_0000201370Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi286636.M6_Spy0224.

Structurei

3D structure databases

ProteinModelPortaliQ5XE04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OrthoDBiEOG6Z9B3V.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XE04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI
60 70 80 90 100
EEILIVTGKS KRSIEDHFDS NFELEYNLQA KGKIELLKLV DETTSINLHF
110 120 130 140 150
IRQSHPRGLG DAVLQAKTFV GNEPFVVMLG DDLMDITNPN VKPLTKQLID
160 170 180 190 200
DYEETHAATI AVMRVPHEDV SNYGIIAPQA KAVKGLYSVD TFVEKPQPQD
210 220 230 240 250
APSDLAIIGR YLLTPEIFSI LEKQEPGAGN EVQLTDAIDT LNKTQRVFAR
260 270 280 290
EFKGKRYDVG DKFGFMKTSL DYALKHPQVK DDLKAYIIQL GKALEKTKP
Length:299
Mass (Da):33,302
Last modified:August 30, 2005 - v2
Checksum:iD927314E58F6091B
GO

Sequence cautioni

The sequence AAT86359.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT86359.1. Different initiation.
RefSeqiYP_059542.1. NC_006086.1.

Genome annotation databases

EnsemblBacteriaiAAT86359; AAT86359; M6_Spy0224.
GeneIDi2942251.
KEGGispa:M6_Spy0224.
PATRICi19722545. VBIStrPyo30273_0228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT86359.1. Different initiation.
RefSeqiYP_059542.1. NC_006086.1.

3D structure databases

ProteinModelPortaliQ5XE04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi286636.M6_Spy0224.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT86359; AAT86359; M6_Spy0224.
GeneIDi2942251.
KEGGispa:M6_Spy0224.
PATRICi19722545. VBIStrPyo30273_0228.

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OrthoDBiEOG6Z9B3V.

Enzyme and pathway databases

UniPathwayiUPA00215.
BioCyciSPYO286636:GHNO-274-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain."
    Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.
    J. Infect. Dis. 190:727-738(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-946 / MGAS10394.

Entry informationi

Entry nameiHASC1_STRP6
AccessioniPrimary (citable) accession number: Q5XE04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: January 7, 2015
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.