Q5XE04 (HASC1_STRP6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UTP--glucose-1-phosphate uridylyltransferase 1
EC=2.7.7.9

Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase 1
UDP-glucose pyrophosphorylase 1
Short name=UDPGP 1
Uridine diphosphoglucose pyrophosphorylase 1

Gene names

Name:	hasC1
Synonyms:	hasC
Ordered Locus Names:	M6_Spy0224

Organism

Streptococcus pyogenes serotype M6 [Complete proteome] [HAMAP]

Taxonomic identifier

301450 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Carbohydrate metabolism; nucleotide-sugar metabolism.
Sequence similarities	Belongs to the UDPGP type 2 family.
Sequence caution	The sequence AAT86359.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	UTP--glucose-1-phosphate uridylyltransferase 1		PRO_0000201370

Sequences

	Sequence		Length	Mass (Da)
	Q5XE04 [UniParc]. Last modified August 30, 2005. Version 2. Checksum: D927314E58F6091B	FASTA	299	33,302
	10 20 30 40 50 60 MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI EEILIVTGKS 70 80 90 100 110 120 KRSIEDHFDS NFELEYNLQA KGKIELLKLV DETTSINLHF IRQSHPRGLG DAVLQAKTFV 130 140 150 160 170 180 GNEPFVVMLG DDLMDITNPN VKPLTKQLID DYEETHAATI AVMRVPHEDV SNYGIIAPQA 190 200 210 220 230 240 KAVKGLYSVD TFVEKPQPQD APSDLAIIGR YLLTPEIFSI LEKQEPGAGN EVQLTDAIDT 250 260 270 280 290 LNKTQRVFAR EFKGKRYDVG DKFGFMKTSL DYALKHPQVK DDLKAYIIQL GKALEKTKP

References

[1]

"Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain." Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M. J. Infect. Dis. 190:727-738(2004) [PubMed: 15272401] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-946 / MGAS10394 / Serotype M6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000003 Genomic DNA. Translation: AAT86359.1. Different initiation.
RefSeq	YP_059542.1. NC_006086.1.
3D structure databases
ProteinModelPortal	Q5XE04.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000037585; EBSTRP00000036158; EBSTRG00000037583.
GeneID	2942251.
GenomeReviews	Gene locus M6_Spy0224 in contig CP000003_GR.
KEGG	spa:M6_Spy0224.
PATRIC	19722545. VBIStrPyo30273_0228.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000026808.
HOGENOM	HBG688195.
OMA	HAKPWIG.
ProtClustDB	CLSK877010.
Enzyme and pathway databases
BioCyc	SPYO286636:M6_SPY0224-MONOMER.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
KO	K00963.
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. GalU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HASC1_STRP6

Accession

Primary (citable) accession number: Q5XE04

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	August 30, 2005
Last modified:	January 25, 2012
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program