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Protein

Non-canonical purine NTP pyrophosphatase

Gene

M6_Spy0330

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity).By similarity

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi196 – 1961Magnesium or manganeseBy similarity
Binding sitei283 – 2831SubstrateBy similarity
Binding sitei303 – 3031SubstrateBy similarity
Binding sitei309 – 3091SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO286636:GHNO-386-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical purine NTP pyrophosphatase (EC:3.6.1.19)
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name:
NTPase
Gene namesi
Ordered Locus Names:M6_Spy0330
OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Taxonomic identifieri286636 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001167 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Non-canonical purine NTP pyrophosphatasePRO_0000178244Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5XDP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 129129UnknownAdd
BLAST
Regioni130 – 324195NTP pyrophosphataseAdd
BLAST
Regioni134 – 1396Substrate bindingBy similarity
Regioni196 – 1972Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the HAM1 NTPase family.Curated

Phylogenomic databases

HOGENOMiHOG000293319.
KOiK02428.

Family and domain databases

CDDicd00515. HAM1. 1 hit.
Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase. 1 hit.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XDP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKIYEYKD ENNWFIGKMT GHNLISGWGV KHRTIKKIDD LLDGIAATLD
60 70 80 90 100
WENPKGYDVS VVRYQSPLSL ITFIIDMINQ ETQREIKVIP HAGTILLMEN
110 120 130 140 150
AKLLAVYLPE GGVSTATFFA TSEQGFGDTI LIATRNEGKT KEFRNLFGQL
160 170 180 190 200
GYRVENLNDY PELPEVAETG TTFEENARLK AETISHLTGK MVLADDSGLK
210 220 230 240 250
VDALGDLPGV WSARFSGPDA TDAKNNAKLL HELAMVFDQK KRSAQFHTTL
260 270 280 290 300
VVAAPNKDSL VVEAEWPGYI ATQPKGENGF GYDPVFIVGE TGRHAAELEA
310 320
DQKNQLSHRG QAVRKLMEVF PAWQAKQS
Length:328
Mass (Da):36,445
Last modified:April 26, 2005 - v2
Checksum:i8C05ED79DA7662B8
GO

Sequence cautioni

The sequence AAT86465 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT86465.1. Different initiation.
RefSeqiWP_011184197.1. NC_006086.1.

Genome annotation databases

EnsemblBacteriaiAAT86465; AAT86465; M6_Spy0330.
KEGGispa:M6_Spy0330.
PATRICi19722773. VBIStrPyo30273_0336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT86465.1. Different initiation.
RefSeqiWP_011184197.1. NC_006086.1.

3D structure databases

ProteinModelPortaliQ5XDP8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT86465; AAT86465; M6_Spy0330.
KEGGispa:M6_Spy0330.
PATRICi19722773. VBIStrPyo30273_0336.

Phylogenomic databases

HOGENOMiHOG000293319.
KOiK02428.

Enzyme and pathway databases

BioCyciSPYO286636:GHNO-386-MONOMER.

Family and domain databases

CDDicd00515. HAM1. 1 hit.
Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase. 1 hit.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNTPA_STRP6
AccessioniPrimary (citable) accession number: Q5XDP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.