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Protein

Thymidylate kinase

Gene

tmk

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:M6_Spy0356
OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Taxonomic identifieri286636 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001167 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001553531 – 211Thymidylate kinaseAdd BLAST211

Structurei

3D structure databases

ProteinModelPortaliQ5XDM2.
SMRiQ5XDM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229078.
KOiK00943.

Family and domain databases

HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
PANTHERiPTHR10344:SF4. PTHR10344:SF4. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XDM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITGKLITVE GPDGAGKTTV LEQLIPLLKQ KVAQEILTTR EPGGVAISEY
60 70 80 90 100
IRELILDINH TAMDPKTELL LYIAARRQHL VEKVLPALEA GQLVFIDRFI
110 120 130 140 150
DSSVAYQGAG RGLIKADIQW LNEFATDGLE PDLTLYFDVP SEIGLARINA
160 170 180 190 200
NQQREVNRLD LETIEIHQRV RKGYLALAKE HPKRIVTIDA TKPLKEVVSV
210
ALEHVLALLL A
Length:211
Mass (Da):23,442
Last modified:February 15, 2005 - v2
Checksum:i8DBB3A06DFC5468F
GO

Sequence cautioni

The sequence AAT86491 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT86491.1. Different initiation.
RefSeqiWP_011184214.1. NC_006086.1.

Genome annotation databases

EnsemblBacteriaiAAT86491; AAT86491; M6_Spy0356.
KEGGispa:M6_Spy0356.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKTHY_STRP6
AccessioniPrimary (citable) accession number: Q5XDM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: June 7, 2017
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families