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Protein

Peptide methionine sulfoxide reductase MsrB

Gene

msrB

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei116 – 1161NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciSPYO286636:GHNO-858-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrBUniRule annotation (EC:1.8.4.12UniRule annotation)
Alternative name(s):
Peptide-methionine (R)-S-oxide reductaseUniRule annotation
Gene namesi
Name:msrBUniRule annotation
Ordered Locus Names:M6_Spy0798
OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Taxonomic identifieri286636 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001167 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Peptide methionine sulfoxide reductase MsrBPRO_0000140309Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5XCD0.
SMRiQ5XCD0. Positions 3-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 127124MsrBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MsrB Met sulfoxide reductase family.UniRule annotation
Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000243425.
KOiK07305.
OMAiRMQYEVT.
OrthoDBiEOG6091JX.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XCD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSEELKQR IGDLSYEVTQ HAATESPFTG EYDDFFEKGI YVDIVSGEVL
60 70 80 90 100
FSSLDKFNSG CGWPAFSKPI ENRMVINHDD SSYGMRRVEV KSREAGSHLG
110 120 130 140
HVFSDGPKEA GGLRYCINSA ALKFIPYEQM EKEGYAQWLT LFDET
Length:145
Mass (Da):16,395
Last modified:November 23, 2004 - v1
Checksum:i8FCDA08945DA49B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT86933.1.
RefSeqiWP_011184472.1. NC_006086.1.

Genome annotation databases

EnsemblBacteriaiAAT86933; AAT86933; M6_Spy0798.
KEGGispa:M6_Spy0798.
PATRICi19723762. VBIStrPyo30273_0826.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT86933.1.
RefSeqiWP_011184472.1. NC_006086.1.

3D structure databases

ProteinModelPortaliQ5XCD0.
SMRiQ5XCD0. Positions 3-136.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT86933; AAT86933; M6_Spy0798.
KEGGispa:M6_Spy0798.
PATRICi19723762. VBIStrPyo30273_0826.

Phylogenomic databases

HOGENOMiHOG000243425.
KOiK07305.
OMAiRMQYEVT.
OrthoDBiEOG6091JX.

Enzyme and pathway databases

BioCyciSPYO286636:GHNO-858-MONOMER.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain."
    Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.
    J. Infect. Dis. 190:727-738(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-946 / MGAS10394.

Entry informationi

Entry nameiMSRB_STRP6
AccessioniPrimary (citable) accession number: Q5XCD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: November 23, 2004
Last modified: April 13, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.