ID   FOLB_STRP6              Reviewed;         119 AA.
AC   Q5XCA7;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Dihydroneopterin aldolase;
DE            Short=DHNA;
DE            EC=4.1.2.25;
GN   Name=folB; Synonyms=folQ; OrderedLocusNames=M6_Spy0821;
OS   Streptococcus pyogenes serotype M6.
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394 / Serotype M6;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus
RT   metagenome: complete genome sequence of a macrolide-resistant serotype
RT   M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
CC   -!- FUNCTION: Catalyzes the conversion of 7,8-dihydroneopterin to 6-
CC       hydroxymethyl-7,8-dihydropterin.
CC   -!- CATALYTIC ACTIVITY: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-
CC       trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-
CC       hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-
CC       amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
CC       from 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-
CC       dihydropteridine triphosphate: step 3/4.
CC   -!- SIMILARITY: Belongs to the DHNA family.
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DR   EMBL; CP000003; AAT86956.1; -; Genomic_DNA.
DR   RefSeq; YP_060139.1; -.
DR   GeneID; 2940919; -.
DR   GenomeReviews; CP000003_GR; M6_Spy0821.
DR   KEGG; spa:M6_Spy0821; -.
DR   HOGENOM; Q5XCA7; -.
DR   OMA; Q5XCA7; HAPIAAI.
DR   BioCyc; SPYO286636:M6_SPY0821-MON; -.
DR   BRENDA; 4.1.2.25; 314561.
DR   GO; GO:0004150; F:dihydroneopterin aldolase activity; IEA:EC.
DR   GO; GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR006157; FolB.
DR   InterPro; IPR006156; FolB_fam.
DR   PANTHER; PTHR20941:SF3; FolB; 1.
DR   Pfam; PF02152; FolB; 1.
DR   TIGRFAMs; TIGR00525; folB; 1.
DR   TIGRFAMs; TIGR00526; folB_dom; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Folate biosynthesis; Lyase.
FT   CHAIN         1    119       Dihydroneopterin aldolase.
FT                                /FTId=PRO_0000168291.
SQ   SEQUENCE   119 AA;  13399 MW;  5BD1D781950FD4F8 CRC64;
     MDKIVLESCR FYGYHGAFKE EQTLGQIFLV DLELSVDLQA ASLSDQLTDT VHYGMVFDSV
     RQLVEGGKFI LIERLAGAIC EQLFNEFPPI EAIKVAIKKE NPPIAGHYKA VGIELERQR
//