Reviewed, UniProtKB/Swiss-Prot Q5XCA7 (FOLB_STRP6)

Names and origin

Protein names

Recommended name:
    Dihydroneopterin aldolase
      Short name=DHNA
    EC=4.1.2.25

Gene names

Name:	folB
Synonyms:	folQ
Ordered Locus Names:	M6_Spy0821

Organism

Streptococcus pyogenes serotype M6 [Complete proteome] [HAMAP]

Taxonomic identifier

301450 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	119 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
Catalytic activity	2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate: step 3/4.
Sequence similarities	Belongs to the DHNA family.

Ontologies

Keywords
Biological process	Folate biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	dihydroneopterin aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 119	119	Dihydroneopterin aldolase		PRO_0000168291

Sequences

	Sequence		Length	Mass (Da)
	Q5XCA7-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 5BD1D781950FD4F8	FASTA	119	13,399
	10 20 30 40 50 60 MDKIVLESCR FYGYHGAFKE EQTLGQIFLV DLELSVDLQA ASLSDQLTDT VHYGMVFDSV 70 80 90 100 110 RQLVEGGKFI LIERLAGAIC EQLFNEFPPI EAIKVAIKKE NPPIAGHYKA VGIELERQR

References

[1]

"Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain." Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M. J. Infect. Dis. 190:727-738(2004) [PubMed: 15272401] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-946 / MGAS10394 / Serotype M6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000003 Genomic DNA. Translation: AAT86956.1.
RefSeq	YP_060139.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2940919.
GenomeReviews	Gene locus M6_Spy0821 in contig CP000003_GR.
KEGG	spa:M6_Spy0821.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5XCA7.
OMA	Q5XCA7. HAPIAAI.
Enzyme and pathway databases
BioCyc	SPYO286636:M6_SPY0821-MON.
BRENDA	4.1.2.25. 314561.
Family and domain databases
InterPro	IPR006157. FolB. IPR006156. FolB_fam. [Graphical view]
PANTHER	PTHR20941:SF3. FolB. 1 hit.
Pfam	PF02152. FolB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00525. folB. 1 hit. TIGR00526. folB_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FOLB_STRP6

Accession

Primary (citable) accession number: Q5XCA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	November 23, 2004
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)