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Q5XC85 (KPRS2_STRP6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase 2
Short name=RPPK 2
EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase 2
Short name=P-Rib-PP synthase 2
Short name=PRPP synthase 2
Gene names
Name:prs2
Ordered Locus Names:M6_Spy0843
OrganismStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) [Complete proteome] [HAMAP]
Taxonomic identifier286636 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00583

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP-Rule MF_00583

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Mass spectrometry

Molecular mass is 35707.93 Da from positions 1 - 326. Determined by ESI. Ref.2

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Ribose-phosphate pyrophosphokinase 2 HAMAP-Rule MF_00583
PRO_0000141213

Regions

Region218 – 23114Binding of phosphoribosylpyrophosphate Potential

Sites

Metal binding1341Magnesium Potential
Metal binding1361Magnesium Potential
Metal binding1451Magnesium Potential
Metal binding1491Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
Q5XC85 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: A5AAAAECE67CE1AC

FASTA32635,723
        10         20         30         40         50         60 
MTERYADKQI KLFSLTSNLP IAEKIAKAAG IPLGKMSSRQ FSDGEIMINI EETVRGDDIY 

        70         80         90        100        110        120 
IIQSTSFPVN DNLWELLIMI DACKRASANT VNIVLPYFGY SRQDRVAKPR EPITAKLVAN 

       130        140        150        160        170        180 
MLTKAGIDRV VTLDLHAVQV QGFFDIPVDN LFTVPLFAER YSKLGLSGSD VVVVSPKNSG 

       190        200        210        220        230        240 
IKRARSLAEY LDSPIAIIDY AQDDSEREQG YIIGDVSGKK AILIDDILNT GKTFAEAAKI 

       250        260        270        280        290        300 
LERSGATDTY AVASHGLFAG GAAEVLETAP IKEIIVTDSV KTKNRVPENV TYLSASDLIA 

       310        320 
EAIIRIHERR PLSPLFSYQP KGKNNA

« Hide

References

« Hide 'large scale' references
[1]"Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain."
Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.
J. Infect. Dis. 190:727-738(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-946 / MGAS10394.
[2]"Two-dimensional gel electrophoresis map of Streptococcus pyogenes proteins."
Hogan D.A., Du P., Stevenson T.I., Whitton M., Kilby G.W., Rogers J., VanBogelen R.A.
Submitted (MAY-2000) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 164-177; 220-232 AND 310-321, MASS SPECTROMETRY.
Strain: JRS4 / Serotype M6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000003 Genomic DNA. Translation: AAT86978.1.
RefSeqYP_060161.1. NC_006086.1.

3D structure databases

ProteinModelPortalQ5XC85.
SMRQ5XC85. Positions 10-317.
ModBaseSearch...

Protein-protein interaction databases

STRING286636.M6_Spy0843.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT86978; AAT86978; M6_Spy0843.
GeneID2942249.
KEGGspa:M6_Spy0843.
PATRIC19723854. VBIStrPyo30273_0872.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0462.
HOGENOMHOG000210449.
KOK00948.
OMACMELSKR.
ProtClustDBPRK02458.

Enzyme and pathway databases

UniPathwayUPA00087; UER00172.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase_dom.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. ribP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPRS2_STRP6
AccessionPrimary (citable) accession number: Q5XC85
Secondary accession number(s): P82570
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 23, 2004
Last modified: May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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