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Q5XC70

- KITH_STRP6

UniProt

Q5XC70 - KITH_STRP6

Protein

Thymidine kinase

Gene

tdk

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861Proton acceptorUniRule annotation
    Metal bindingi143 – 1431ZincUniRule annotation
    Metal bindingi146 – 1461ZincUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation
    Metal bindingi183 – 1831ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi85 – 884ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciSPYO286636:GHNO-918-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:M6_Spy0858
    OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
    Taxonomic identifieri286636 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001167: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 189189Thymidine kinasePRO_0000175036Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi286636.M6_Spy0858.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XC70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076391.
    KOiK00857.
    OMAiAIPITAD.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5XC70-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQLYYKYGT MNSGKTIEIL KVAHNYEEQG KPVVIMTSAL DTRDGFGIVS    50
    SRIGMRREAI PISNDIDIFT FIAQLEEKPY CVLIDESQFL SKQNVYDLAR 100
    VVDELNVPVM AFGLKNDFQN NLFEGSKHLL LLADKIDEIK TICQYCSKKA 150
    TMVLRTENGK PVYEGDQIQI GGNETYIPVC RKHYFNPEI 189
    Length:189
    Mass (Da):21,529
    Last modified:November 23, 2004 - v1
    Checksum:iBF8F9E3DA09F821E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000003 Genomic DNA. Translation: AAT86993.1.
    RefSeqiYP_060176.1. NC_006086.1.

    Genome annotation databases

    EnsemblBacteriaiAAT86993; AAT86993; M6_Spy0858.
    GeneIDi2941721.
    KEGGispa:M6_Spy0858.
    PATRICi19723884. VBIStrPyo30273_0887.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000003 Genomic DNA. Translation: AAT86993.1 .
    RefSeqi YP_060176.1. NC_006086.1.

    3D structure databases

    ProteinModelPortali Q5XC70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 286636.M6_Spy0858.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT86993 ; AAT86993 ; M6_Spy0858 .
    GeneIDi 2941721.
    KEGGi spa:M6_Spy0858.
    PATRICi 19723884. VBIStrPyo30273_0887.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076391.
    KOi K00857.
    OMAi AIPITAD.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci SPYO286636:GHNO-918-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain."
      Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.
      J. Infect. Dis. 190:727-738(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-946 / MGAS10394.

    Entry informationi

    Entry nameiKITH_STRP6
    AccessioniPrimary (citable) accession number: Q5XC70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3