Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activity1
Active sitei599For Fru-6P isomerization activity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Protein family/group databases

MEROPSiC44.A08.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:M6_Spy0972
OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Taxonomic identifieri286636 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001167 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001353952 – 604Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST603

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ5XBV6.
SMRiQ5XBV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2Add BLAST217
Domaini284 – 423SIS 1Add BLAST140
Domaini456 – 594SIS 2Add BLAST139

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

HOGENOMiHOG000258896.
KOiK00820.
OMAiASEYRYA.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XBV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGVVGN RNATDILMQG LEKLEYRGYD SAGIFVANGD KLSLVKSVGR
60 70 80 90 100
IADLRSKIGI DVAGSTGIGH TRWATHGQAT VENAHPHTSA SSRFVLVHNG
110 120 130 140 150
VIENYLQMKE EYLAGHEFKG QTDTEIAVHL IGKFVEEDGL SVLEAFKNAL
160 170 180 190 200
SIIEGSYAFA LIDTEDADTI YVAKNKSPLL IGLGEGYNMV CSDAMAMIRE
210 220 230 240 250
TSQFMEIHDK ELVILTKDSV TVLDYDGNQL ERDSYTAELD LSDIGKGTYP
260 270 280 290 300
FYMLKEIDEQ PTVMRKLIST YSDESGKMAI DPAIVKTIQE ADRIYILAAG
310 320 330 340 350
TSYNAGFASK AMIEQLTDTP VELGVASEWG YNMPLLSQKP MFILLSQSGE
360 370 380 390 400
TADSRQVLVK ANQMGIPSLT VTNVPGSTLS REATYTMLLH AGPEIAVAST
410 420 430 440 450
KAYTAQVAAL AFLSKAVGEA NGKKEALEFD LVHELSLVAQ SIEATLSEKD
460 470 480 490 500
LIASKVEKLL ATTRNAFYIG RGNDYYVAME ASLKLKEISY IQCEGFAAGE
510 520 530 540 550
LKHGTISLIE DGTPVIGLIS SSELVAAHTR GNIQEVAARG ASVLTVVEEG
560 570 580 590 600
LDREGDDIVV NKVHPYLATI GMVIPTQLIA YYASLQRGLD VDKPRNLAKA

VTVE
Length:604
Mass (Da):65,331
Last modified:January 23, 2007 - v3
Checksum:iBC4FDDB5DE2CED07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT87107.1.
RefSeqiWP_011184570.1. NC_006086.1.

Genome annotation databases

EnsemblBacteriaiAAT87107; AAT87107; M6_Spy0972.
KEGGispa:M6_Spy0972.

Similar proteinsi

Entry informationi

Entry nameiGLMS_STRP6
AccessioniPrimary (citable) accession number: Q5XBV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 90 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome