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Protein

Exotoxin type C

Gene

speC

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Enzyme and pathway databases

BioCyciSPYO286636:GHNO-1256-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exotoxin type C
Alternative name(s):
SPE C
Gene namesi
Name:speC
Ordered Locus Names:M6_Spy1196
OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Taxonomic identifieri286636 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001167 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Protein family/group databases

Allergomei8279. Str py SPEC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727By similarityAdd
BLAST
Chaini28 – 235208Exotoxin type CPRO_0000035599Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5XB82.
SMRiQ5XB82. Positions 28-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000235485.
KOiK11040.
OMAiHIIKIVF.
OrthoDBiEOG6KQ6M9.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XB82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKINIIKIV FIITVILIST ISPIIKSDSK KDISNVKSDL LYAYTITPYD
60 70 80 90 100
YKDCRVNFST THTLNIDTQK YRGKDYYISS EMSYEASQKF KRDDHVDVFG
110 120 130 140 150
LFYILNSHTG EYIYGGITPA QNNKVNHKLL GNLFISGESQ QNLNNKIILE
160 170 180 190 200
KDIVTFQEID FKIRKYLMDN YKIYDATSPY VSGRIEIGTK DGKHEQIDLF
210 220 230
DSPNEGTRSD IFAKYKDNRI INMKNFSHFD IYLEK
Length:235
Mass (Da):27,372
Last modified:November 23, 2004 - v1
Checksum:i53EBD041B958C65B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT87331.1.
RefSeqiWP_002985327.1. NC_006086.1.

Genome annotation databases

EnsemblBacteriaiAAT87331; AAT87331; M6_Spy1196.
KEGGispa:M6_Spy1196.
PATRICi19724601. VBIStrPyo30273_1245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT87331.1.
RefSeqiWP_002985327.1. NC_006086.1.

3D structure databases

ProteinModelPortaliQ5XB82.
SMRiQ5XB82. Positions 28-235.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei8279. Str py SPEC.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT87331; AAT87331; M6_Spy1196.
KEGGispa:M6_Spy1196.
PATRICi19724601. VBIStrPyo30273_1245.

Phylogenomic databases

HOGENOMiHOG000235485.
KOiK11040.
OMAiHIIKIVF.
OrthoDBiEOG6KQ6M9.

Enzyme and pathway databases

BioCyciSPYO286636:GHNO-1256-MONOMER.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain."
    Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.
    J. Infect. Dis. 190:727-738(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-946 / MGAS10394.

Entry informationi

Entry nameiSPEC_STRP6
AccessioniPrimary (citable) accession number: Q5XB82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 23, 2004
Last modified: October 14, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Superantigen that binds to major histocompatibility complex class II beta chain in a zinc-dependent manner, it may activate up to 20% of all T-cells. Superantigens bind simultaneously TCRs and MHC class II molecules resulting in a massive release of pyrogenic and inflammatory cytokines (By similarity).By similarity

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.