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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140GTPUniRule annotation1
Binding sitei144GTPUniRule annotation1
Binding sitei188GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 26GTPUniRule annotation5
Nucleotide bindingi109 – 111GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:M6_Spy1270Imported
OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)Imported
Taxonomic identifieri286636 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001167 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5XB08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 206TubulinInterPro annotationAdd BLAST193
Domaini208 – 325Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000049094.
KOiK03531.
OMAiMRAVKGI.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiView protein in InterPro
IPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
PfamiView protein in Pfam
PF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiView protein in PROSITE
PS01134. FTSZ_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XB08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFSFDTASI QGAIIKVIGV GGGGGNAINR MIDEGVAGVE FIAANTDIQA
60 70 80 90 100
LSSSKAETVI QLGPKLTRGL GAGGQPEVGR KAAEESEEIL TEALTGADMV
110 120 130 140 150
FITAGMGGGS GTGAAPVIAR IAKSLGALTV AVVTRPFGFE GNKRGNFAIE
160 170 180 190 200
GIEELREQVD TLLIISNNNL LEIVDKKTPL LEALSEADNV LRQGVQGITD
210 220 230 240 250
LITSPGLINL DFADVKTVMA NKGNALMGIG IGSGEERIVE AARKAIYSPL
260 270 280 290 300
LETTIDGAQD VIVNVTGGLD MTLTEAEEAS EIVGQAAGQG VNIWLGTSID
310 320 330 340 350
DTMKDDIRVT VVATGVRQEK AEQVSGFRQP RTFTQTNAQQ VAGAQYASDQ
360 370 380 390 400
AKQSVQPGFD RRSNFDFDMG ESREIPSAQK VISNHNQNQG SAFGNWDLRR
410 420 430
DNISRPTEGE LDNHLNMSTF SANDDSDDEL ETPPFFKNR
Length:439
Mass (Da):46,432
Last modified:November 23, 2004 - v1
Checksum:iE8872562C15A3836
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT87405.1.
RefSeqiWP_002983862.1. NC_006086.1.

Genome annotation databases

EnsemblBacteriaiAAT87405; AAT87405; M6_Spy1270.
KEGGispa:M6_Spy1270.

Similar proteinsi

Entry informationi

Entry nameiQ5XB08_STRP6
AccessioniPrimary (citable) accession number: Q5XB08
Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: September 27, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported