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Q5XAP6 (PP2C_STRP6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative protein phosphatase 2C-type

EC=3.1.3.16
Gene names
Ordered Locus Names:M6_Spy1382
OrganismStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) [Complete proteome] [HAMAP]
Taxonomic identifier286636 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. UniProtKB O14156

Sequence similarities

Contains 1 PP2C-like domain.

Mass spectrometry

Molecular mass is 27020.19 Da from positions 1 - 246. Determined by ESI. Ref.2

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Putative protein phosphatase 2C-type
PRO_0000273577

Regions

Domain1 – 233233PP2C-like

Sites

Metal binding361Manganese 1 By similarity UniProtKB O14156
Metal binding361Manganese 2 By similarity UniProtKB O14156
Metal binding371Manganese 1; via carbonyl oxygen By similarity
Metal binding1921Manganese 2 By similarity UniProtKB O14156
Metal binding2311Manganese 2 By similarity UniProtKB O14156

Sequences

Sequence LengthMass (Da)Tools
Q5XAP6 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: EF253B14CCE2AEA0

FASTA24627,020
        10         20         30         40         50         60 
MKISLKTDIG QKRSNNQDFI NKFDNKKGIT LVILADGMGG HRAGNIASEM TVTDLGREWV 

        70         80         90        100        110        120 
KTDFTELSQI RDWLFETIQS ENQRIYDLGQ SEDFKGMGTT VEAVALVESS AIYAHIGDSR 

       130        140        150        160        170        180 
IGLVHDGHYT LLTSDHSLVN ELVKAGQITE EEAASHPQRN IITQSIGQAS PVEPDLGVRV 

       190        200        210        220        230        240 
LEPGDYLVIN SDGLTNMISN DEIVTILGSK VSLDEKNQEM IDLANLRGGL DNITIALVHN 


ESEDVE 

« Hide

References

« Hide 'large scale' references
[1]"Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain."
Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.
J. Infect. Dis. 190:727-738(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-946 / MGAS10394.
[2]"Two-dimensional gel electrophoresis map of Streptococcus pyogenes proteins."
Hogan D.A., Du P., Stevenson T.I., Whitton M., Kilby G.W., Rogers J., VanBogelen R.A.
Submitted (MAY-2000) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 28-57; 85-120 AND 217-227, MASS SPECTROMETRY.
Strain: JRS4 / Serotype M6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000003 Genomic DNA. Translation: AAT87517.1.
RefSeqYP_060700.1. NC_006086.1.

3D structure databases

ProteinModelPortalQ5XAP6.
SMRQ5XAP6. Positions 1-242.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING286636.M6_Spy1382.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT87517; AAT87517; M6_Spy1382.
GeneID2941560.
KEGGspa:M6_Spy1382.
PATRIC19725005. VBIStrPyo30273_1435.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000235782.
KOK01090.
OMAHEECQGM.
OrthoDBEOG65N17S.

Enzyme and pathway databases

BioCycSPYO286636:GHNO-1454-MONOMER.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
ProtoNetSearch...

Entry information

Entry namePP2C_STRP6
AccessionPrimary (citable) accession number: Q5XAP6
Secondary accession number(s): P82576
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families