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Q5XAP6

- PP2C_STRP6

UniProt

Q5XAP6 - PP2C_STRP6

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Protein

Putative protein phosphatase 2C-type

Gene

M6_Spy1382

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Manganese 1By similarity
Metal bindingi36 – 361Manganese 2By similarity
Metal bindingi37 – 371Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi192 – 1921Manganese 2By similarity
Metal bindingi231 – 2311Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSPYO286636:GHNO-1454-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein phosphatase 2C-type (EC:3.1.3.16)
Gene namesi
Ordered Locus Names:M6_Spy1382
OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Taxonomic identifieri286636 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001167: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Putative protein phosphatase 2C-typePRO_0000273577Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi286636.M6_Spy1382.

Structurei

3D structure databases

ProteinModelPortaliQ5XAP6.
SMRiQ5XAP6. Positions 1-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 233233PP2C-likeSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 PP2C-like domain.Sequence Analysis

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000235782.
KOiK01090.
OMAiHEECQGM.
OrthoDBiEOG65N17S.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XAP6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKISLKTDIG QKRSNNQDFI NKFDNKKGIT LVILADGMGG HRAGNIASEM
60 70 80 90 100
TVTDLGREWV KTDFTELSQI RDWLFETIQS ENQRIYDLGQ SEDFKGMGTT
110 120 130 140 150
VEAVALVESS AIYAHIGDSR IGLVHDGHYT LLTSDHSLVN ELVKAGQITE
160 170 180 190 200
EEAASHPQRN IITQSIGQAS PVEPDLGVRV LEPGDYLVIN SDGLTNMISN
210 220 230 240
DEIVTILGSK VSLDEKNQEM IDLANLRGGL DNITIALVHN ESEDVE
Length:246
Mass (Da):27,020
Last modified:November 23, 2004 - v1
Checksum:iEF253B14CCE2AEA0
GO

Mass spectrometryi

Molecular mass is 27020.19 Da from positions 1 - 246. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000003 Genomic DNA. Translation: AAT87517.1.
RefSeqiYP_060700.1. NC_006086.1.

Genome annotation databases

EnsemblBacteriaiAAT87517; AAT87517; M6_Spy1382.
GeneIDi2941560.
KEGGispa:M6_Spy1382.
PATRICi19725005. VBIStrPyo30273_1435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000003 Genomic DNA. Translation: AAT87517.1 .
RefSeqi YP_060700.1. NC_006086.1.

3D structure databases

ProteinModelPortali Q5XAP6.
SMRi Q5XAP6. Positions 1-242.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 286636.M6_Spy1382.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT87517 ; AAT87517 ; M6_Spy1382 .
GeneIDi 2941560.
KEGGi spa:M6_Spy1382.
PATRICi 19725005. VBIStrPyo30273_1435.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000235782.
KOi K01090.
OMAi HEECQGM.
OrthoDBi EOG65N17S.

Enzyme and pathway databases

BioCyci SPYO286636:GHNO-1454-MONOMER.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain."
    Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.
    J. Infect. Dis. 190:727-738(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-946 / MGAS10394.
  2. "Two-dimensional gel electrophoresis map of Streptococcus pyogenes proteins."
    Hogan D.A., Du P., Stevenson T.I., Whitton M., Kilby G.W., Rogers J., VanBogelen R.A.
    Submitted (MAY-2000) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 28-57; 85-120 AND 217-227, MASS SPECTROMETRY.
    Strain: JRS4 / Serotype M61 Publication.

Entry informationi

Entry nameiPP2C_STRP6
AccessioniPrimary (citable) accession number: Q5XAP6
Secondary accession number(s): P82576
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 23, 2004
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3