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Q5XAP6

- PP2C_STRP6

UniProt

Q5XAP6 - PP2C_STRP6

Protein

Putative protein phosphatase 2C-type

Gene

M6_Spy1382

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi36 – 361Manganese 1By similarity
    Metal bindingi36 – 361Manganese 2By similarity
    Metal bindingi37 – 371Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi192 – 1921Manganese 2By similarity
    Metal bindingi231 – 2311Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSPYO286636:GHNO-1454-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative protein phosphatase 2C-type (EC:3.1.3.16)
    Gene namesi
    Ordered Locus Names:M6_Spy1382
    OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
    Taxonomic identifieri286636 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001167: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Putative protein phosphatase 2C-typePRO_0000273577Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi286636.M6_Spy1382.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XAP6.
    SMRiQ5XAP6. Positions 1-242.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 233233PP2C-likeSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PP2C-like domain.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000235782.
    KOiK01090.
    OMAiHEECQGM.
    OrthoDBiEOG65N17S.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5XAP6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKISLKTDIG QKRSNNQDFI NKFDNKKGIT LVILADGMGG HRAGNIASEM    50
    TVTDLGREWV KTDFTELSQI RDWLFETIQS ENQRIYDLGQ SEDFKGMGTT 100
    VEAVALVESS AIYAHIGDSR IGLVHDGHYT LLTSDHSLVN ELVKAGQITE 150
    EEAASHPQRN IITQSIGQAS PVEPDLGVRV LEPGDYLVIN SDGLTNMISN 200
    DEIVTILGSK VSLDEKNQEM IDLANLRGGL DNITIALVHN ESEDVE 246
    Length:246
    Mass (Da):27,020
    Last modified:November 23, 2004 - v1
    Checksum:iEF253B14CCE2AEA0
    GO

    Mass spectrometryi

    Molecular mass is 27020.19 Da from positions 1 - 246. Determined by ESI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000003 Genomic DNA. Translation: AAT87517.1.
    RefSeqiYP_060700.1. NC_006086.1.

    Genome annotation databases

    EnsemblBacteriaiAAT87517; AAT87517; M6_Spy1382.
    GeneIDi2941560.
    KEGGispa:M6_Spy1382.
    PATRICi19725005. VBIStrPyo30273_1435.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000003 Genomic DNA. Translation: AAT87517.1 .
    RefSeqi YP_060700.1. NC_006086.1.

    3D structure databases

    ProteinModelPortali Q5XAP6.
    SMRi Q5XAP6. Positions 1-242.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 286636.M6_Spy1382.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT87517 ; AAT87517 ; M6_Spy1382 .
    GeneIDi 2941560.
    KEGGi spa:M6_Spy1382.
    PATRICi 19725005. VBIStrPyo30273_1435.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000235782.
    KOi K01090.
    OMAi HEECQGM.
    OrthoDBi EOG65N17S.

    Enzyme and pathway databases

    BioCyci SPYO286636:GHNO-1454-MONOMER.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain."
      Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.
      J. Infect. Dis. 190:727-738(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-946 / MGAS10394.
    2. "Two-dimensional gel electrophoresis map of Streptococcus pyogenes proteins."
      Hogan D.A., Du P., Stevenson T.I., Whitton M., Kilby G.W., Rogers J., VanBogelen R.A.
      Submitted (MAY-2000) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 28-57; 85-120 AND 217-227, MASS SPECTROMETRY.
      Strain: JRS4 / Serotype M61 Publication.

    Entry informationi

    Entry nameiPP2C_STRP6
    AccessioniPrimary (citable) accession number: Q5XAP6
    Secondary accession number(s): P82576
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3