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Q5XAP1

- KGUA_STRP6

UniProt

Q5XAP1 - KGUA_STRP6

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Protein

Guanylate kinase

Gene

gmk

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. guanylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO286636:GHNO-1459-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:M6_Spy1387
OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Taxonomic identifieri286636 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001167: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Guanylate kinasePRO_0000170622Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi286636.M6_Spy1387.

Structurei

3D structure databases

ProteinModelPortaliQ5XAP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 184180Guanylate kinase-likeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation
Contains 1 guanylate kinase-like domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037639.
KOiK00942.
OMAiVELACDR.
OrthoDBiEOG6CP410.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XAP1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSERGLLIVF SGPSGVGKGT VRQEIFSTPD HKFEYSVSMT TRPQRPGEVD
60 70 80 90 100
GVDYFFRTRE EFEELIKTGQ MLEYAEYVGN YYGTPLTYVN ETLDKGIDVF
110 120 130 140 150
LEIEVQGALQ VKSKVPDGVF VFLTPPDLDE LEDRLVGRGT DSQEVIAQRI
160 170 180 190 200
ERAKEEIALM REYDYAVVND EVALAAERVK RIIETEHFRV ERVIGRYDKM
210
IKITKNPFKA K
Length:211
Mass (Da):24,186
Last modified:November 23, 2004 - v1
Checksum:i296B236E67A925D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT87522.1.
RefSeqiYP_060705.1. NC_006086.1.

Genome annotation databases

EnsemblBacteriaiAAT87522; AAT87522; M6_Spy1387.
GeneIDi2942205.
KEGGispa:M6_Spy1387.
PATRICi19725015. VBIStrPyo30273_1440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT87522.1 .
RefSeqi YP_060705.1. NC_006086.1.

3D structure databases

ProteinModelPortali Q5XAP1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 286636.M6_Spy1387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT87522 ; AAT87522 ; M6_Spy1387 .
GeneIDi 2942205.
KEGGi spa:M6_Spy1387.
PATRICi 19725015. VBIStrPyo30273_1440.

Phylogenomic databases

eggNOGi COG0194.
HOGENOMi HOG000037639.
KOi K00942.
OMAi VELACDR.
OrthoDBi EOG6CP410.

Enzyme and pathway databases

BioCyci SPYO286636:GHNO-1459-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00328. Guanylate_kinase.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain."
    Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.
    J. Infect. Dis. 190:727-738(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-946 / MGAS10394.

Entry informationi

Entry nameiKGUA_STRP6
AccessioniPrimary (citable) accession number: Q5XAP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3