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Q5XAK0 (GLPO_STRP6) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alpha-glycerophosphate oxidase
EC=1.1.3.21
Alternative name(s):
Glycerol-3-phosphate oxidase
Gene names
Name:glpO
Synonyms:glpA
Ordered Locus Names:M6_Spy1428
OrganismStreptococcus pyogenes serotype M6 [Complete proteome] [HAMAP]
Taxonomic identifier301450 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length612 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2.

Cofactor

FAD By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

Caution

As S.pyogenes is unable to produce acid from glycerol, the significance and/or function of the glpO gene in this organism is at present unknown.

Ontologies

Keywords
   Biological processGlycerol metabolism
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentglycerol-3-phosphate dehydrogenase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionglycerol-3-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: InterPro

glycerol-3-phosphate oxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 612612Alpha-glycerophosphate oxidase
PRO_0000126112

Regions

Nucleotide binding21 – 4929FAD Potential

Sequences

Sequence LengthMass (Da)Tools
Q5XAK0 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 341CDF7964357A57

FASTA61267,914
        10         20         30         40         50         60 
MEFSKETRRL ALQKMQERDL DLLIIGGGIT GAGVALQAAA SGLDTGLIEM QDFAEGTSSR 

        70         80         90        100        110        120 
STKLVHGGLR YLKQFDVEVV SDTVSERAVV QQIAPHIPKP DPMLLPVYDE PGSTFSMFRL 

       130        140        150        160        170        180 
KVAMDLYDLL AGVSNTPAAN KVLTKEEVLK REPDLKQEGL LGGGVYLDFR NNDARLVIEN 

       190        200        210        220        230        240 
IKRANRDGAL IASHVKAEDF LLDDKRQIIG VKARDLLTDQ EIIIKAKLVI NTTGPWSDEI 

       250        260        270        280        290        300 
RQFSHKGQPI HQMRPTKGVH LVVDRQKLPV SQPVYVDTGL NDGRMVFVLP REEKTYFGTT 

       310        320        330        340        350        360 
DTDYTGDLQH PQVTQEDVDY LLGIVNNRFP NANLTINDIE SSWAGLRPLL SGNSASDYNG 

       370        380        390        400        410        420 
GNSGKLSDDS FDHLIDTVKA YINHEDSREA VEKAIKQVET STSEKELDPS AVSRGSSFER 

       430        440        450        460        470        480 
DENGLFTLAG GKITDYRKMA EGALKVIIQV LKEDFGKSFK LINSTTYPVS GGEINPANVD 

       490        500        510        520        530        540 
SELEAYAQLG TLSGLSMDDA RYLANLYGSN APKVFALTRQ LKAAEGLSLA ETLSLHYAMD 

       550        560        570        580        590        600 
YEMALKPTDY FLRRTNHLLF MRDSLDALIV PVIEEMAKHF DWSTDEKVKQ EEELRRVIAE 

       610 
NDLSALKGQQ ED

« Hide

References

[1]"Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain."
Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.
J. Infect. Dis. 190:727-738(2004) [PubMed: 15272401] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-946 / MGAS10394 / Serotype M6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000003 Genomic DNA. Translation: AAT87563.1.
RefSeqYP_060746.1. NC_006086.1.

3D structure databases

ProteinModelPortalQ5XAK0.
SMRQ5XAK0. Positions 3-608.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000038646; EBSTRP00000037219; EBSTRG00000038644.
GeneID2941714.
GenomeReviewsGene locus M6_Spy1428 in contig CP000003_GR.
KEGGspa:M6_Spy1428.
PATRIC19725097. VBIStrPyo30273_1481.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000027794.
HOGENOMHBG720894.
OMANITRATI.
ProtClustDBCLSK876858.

Enzyme and pathway databases

BioCycSPYO286636:M6_SPY1428-MONOMER.

Family and domain databases

InterProIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
KOK00105.
PfamPF01266. DAO. 1 hit.
[Graphical view]
PRINTSPR01001. FADG3PDH.
PROSITEPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPO_STRP6
AccessionPrimary (citable) accession number: Q5XAK0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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