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Protein

Tagatose 1,6-diphosphate aldolase 1

Gene

lacD1

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Pathwayi: D-tagatose 6-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tagatose-6-phosphate kinase (lacC), Tagatose-6-phosphate kinase (M6_Spy0680)
  2. Tagatose 1,6-diphosphate aldolase 1 (lacD1), Tagatose 1,6-diphosphate aldolase 2 (lacD2)
This subpathway is part of the pathway D-tagatose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lactose metabolism

Enzyme and pathway databases

BioCyciSPYO286636:GHNO-1516-MONOMER.
UniPathwayiUPA00704; UER00716.

Names & Taxonomyi

Protein namesi
Recommended name:
Tagatose 1,6-diphosphate aldolase 1UniRule annotation (EC:4.1.2.40UniRule annotation)
Alternative name(s):
D-tagatose-1,6-bisphosphate aldolase 1UniRule annotation
Tagatose-bisphosphate aldolase 1UniRule annotation
Gene namesi
Name:lacD1UniRule annotation
Ordered Locus Names:M6_Spy1444
OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Taxonomic identifieri286636 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001167 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Tagatose 1,6-diphosphate aldolase 1PRO_0000203963Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5XAI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldolase LacD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000241518.
KOiK01635.
OMAiWANGVES.
OrthoDBiEOG6SR92W.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XAI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITANKRHY LEKVSHQGII SALAFDQRGA LKQMMAAHQE GEATVTQIET
60 70 80 90 100
LKVLVSEELT PYASSILLDP EYGLLATKVK ANQTGLLLAY EKTGYDATTT
110 120 130 140 150
SRLPDCLVEW SVKRLKAAGA DAIKFLLYYD VDGDEQINLQ KQAYIERIGS
160 170 180 190 200
ECTAEDIPFF LELLSYDERI SDNNSAAYAK LKPHKVNGAM SVFSDKRFGV
210 220 230 240 250
DVLKVEVPVN MAYVEGFTEG EVHYSQAEAI KAFQDQEAAS HLPYIYLSAG
260 270 280 290 300
VSAKLFQETL YFAAAAGAQF SGVLCGRATW AGSVPVYITK GEDEARKWLC
310 320
TEGFQNIDEL NRVLEETASP WTEKI
Length:325
Mass (Da):35,983
Last modified:November 23, 2004 - v1
Checksum:iFB342B69AF38F926
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT87579.1.
RefSeqiWP_011106626.1. NC_006086.1.

Genome annotation databases

EnsemblBacteriaiAAT87579; AAT87579; M6_Spy1444.
KEGGispa:M6_Spy1444.
PATRICi19725133. VBIStrPyo30273_1499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA. Translation: AAT87579.1.
RefSeqiWP_011106626.1. NC_006086.1.

3D structure databases

ProteinModelPortaliQ5XAI4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT87579; AAT87579; M6_Spy1444.
KEGGispa:M6_Spy1444.
PATRICi19725133. VBIStrPyo30273_1499.

Phylogenomic databases

HOGENOMiHOG000241518.
KOiK01635.
OMAiWANGVES.
OrthoDBiEOG6SR92W.

Enzyme and pathway databases

UniPathwayiUPA00704; UER00716.
BioCyciSPYO286636:GHNO-1516-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain."
    Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.
    J. Infect. Dis. 190:727-738(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-946 / MGAS10394.

Entry informationi

Entry nameiLACD1_STRP6
AccessioniPrimary (citable) accession number: Q5XAI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.