Q5X9Q9 (M6A_STRP6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
M protein, serotype 6

Gene names

Name:	emm6
Ordered Locus Names:	M6_Spy1719

Organism

Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) [Complete proteome] [HAMAP]

Taxonomic identifier

286636 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pyogenes › Streptococcus pyogenes serotype M6

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Mediates the attachment of S.pyogenes to skin epithelial cells through the binding of the human membrane cofactor protein CD46. Also binds to the factor H and factor H-like protein 1. These interactions could contribute to the fact that the M6 protein protects the bacterium from the phagocytosis by regulating the complement activation on the bacterial surface By similarity.
Subcellular location	Secreted › cell wall; Peptidoglycan-anchor Potential.
Sequence similarities	Belongs to the M protein family.

Ontologies

Keywords
Biological process	Phagocytosis Virulence
Cellular component	Cell wall Secreted
Domain	Coiled coil Repeat Signal
PTM	Peptidoglycan-anchor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW phagocytosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell wall Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 42	42	Potential
	Chain	43 – 384	342	M protein, serotype 6		PRO_0000005617
	Propeptide	385 – 415	31	Removed by sortase Potential		PRO_0000005618
Regions
	Repeat	69 – 75	7	1
	Repeat	76 – 82	7	2
	Repeat	83 – 89	7	3
	Repeat	90 – 96	7	4; approximate
	Repeat	97 – 103	7	5
	Region	69 – 103	35	5 X 7 AA approximate tandem repeats of [KMNR]-L-[TQ]-[TDA]-[ENQ]-N-[NDK]
	Region	211 – 279	69	Binding to CD46 By similarity
	Region	211 – 279	69	Two directly repeated 27 amino acid blocks separated by 15 amino acids
	Region	280 – 343	64	Hydrophilic
	Coiled coil	54 – 133	80	Potential
	Coiled coil	170 – 340	171	Potential
	Motif	381 – 385	5	LPXTG sorting signal Potential
	Compositional bias	344 – 380	37	Gly/Pro-rich
Amino acid modifications
	Modified residue	384	1	Pentaglycyl murein peptidoglycan amidated threonine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5X9Q9 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 4DA7A7451C04A699	FASTA	415	45,751
	10 20 30 40 50 60 MAKNNTNRHY SLRKLKKGTA SVAVALSVIG AGLVVNTNEV SARVFPRGTV ENPDKARELL 70 80 90 100 110 120 NKYDVENSML QANNDKLTTE NKNLTDQNKE LKAEENRLTT ENKGLTKKLS EAEEEAANKE 130 140 150 160 170 180 QESKETIGTL KKILDETVKD KIAREQKSKQ DIGALKQELA KKDEGNKVSE ASRKGLRRDL 190 200 210 220 230 240 DASREAKKQV EKDLANLTAE LDKVKEEKQI SDASRKGLRR DLDASREAKK QVEKDLANLT 250 260 270 280 290 300 AELDKVKEEK QISDASRQGL RRDLDASREA KKQVEKALEE ANSKLAALEK LNKELEESKK 310 320 330 340 350 360 LTEKEKAELQ AKLEAEAKAL KEQLAKQAEE LAKLRAGKAS DSQTPDAKPG NKVVPGKGQA 370 380 390 400 410 PQAGTKPNQN KAPMKETKRQ LPSTGETANP FFTAAALTVM ATAGVAAVVK RKEEN

References

[1]

"Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain." Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M. J. Infect. Dis. 190:727-738(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-946 / MGAS10394.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000003 Genomic DNA. Translation: AAT87854.1.
RefSeq	YP_061037.1. NC_006086.1.
3D structure databases
ProteinModelPortal	Q5X9Q9.
ModBase	Search...
Protein-protein interaction databases
STRING	286636.M6_Spy1719.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAT87854; AAT87854; M6_Spy1719.
GeneID	2940887.
KEGG	spa:M6_Spy1719.
PATRIC	19725728. VBIStrPyo30273_1787.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000235596.
OMA	NEKKRTK.
Family and domain databases
InterPro	IPR005877. Gpos_YSIRK. IPR019948. Gram-positive_anchor. IPR019950. Gram_pos_anchor. IPR019931. LPXTG-motif_cell_wall_anchor. [Graphical view]
Pfam	PF00746. Gram_pos_anchor. 1 hit. PF04650. YSIRK_signal. 1 hit. [Graphical view]
PRINTS	PR00015. GPOSANCHOR.
TIGRFAMs	TIGR01167. LPXTG_anchor. 1 hit. TIGR01168. YSIRK_signal. 1 hit.
PROSITE	PS50847. GRAM_POS_ANCHORING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

M6A_STRP6

Accession

Primary (citable) accession number: Q5X9Q9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program