Reviewed, UniProtKB/Swiss-Prot Q5X9K7 (FTHS2_STRP6)

Names and origin

Protein names

Recommended name:
    Formate--tetrahydrofolate ligase 2
    EC=6.3.4.3
Alternative name(s):
    Formyltetrahydrofolate synthetase 2
      Short name=FHS 2
      Short name=FTHFS 2

Gene names

Name:	fhs2
Ordered Locus Names:	M6_Spy1771

Organism

Streptococcus pyogenes serotype M6 [Complete proteome] [HAMAP]

Taxonomic identifier

301450 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid and derivative biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	Formate--tetrahydrofolate ligase 2 HAMAP MF_01543		PRO_0000199398
Regions
	Nucleotide binding	66 – 73	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5X9K7-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 1811DBE31DE7BF94	FASTA	557	59,118
	10 20 30 40 50 60 MVLSDIEIAN SVTMEPISKV ADQLGIDKET LCLYGKYKAK IDARQLVALK DKPDGKLILV 70 80 90 100 110 120 TAISPTPAGE GKTTTSVGLV DALSAIGKKA VIALREPSLG PVFGVKGGAA GGGHAQVVPM 130 140 150 160 170 180 EDINLHFTGD FHAIGVANNL LAALIDNHIH HGNSLGIDSR RITWKRVVDM NDRQLRHIVD 190 200 210 220 230 240 GLQGKVNGVP REDGYDITVA SEIMAILCLS ENISDLKARL EKIIIGYNFQ GEPVTAKDLK 250 260 270 280 290 300 AGGALAALLK DAIHPNLVQT LEHTPALIHG GPFANIAHGC NSVLATKLAL KYGDYAVTEA 310 320 330 340 350 360 GFGADLGAEK FIDIKCRMSG LRPAAVVLVA TIRALKMHGG VPKADLATEN VQAVVDGLPN 370 380 390 400 410 420 LDKHLANIQD VYGLPVVVAI NKFPLDTDAE LQAVYDACDK RGVDVVISDV WANGGAGGRE 430 440 450 460 470 480 LAEKVVALAE QDNQFRFVYN EDDSIETKLT KIVTKIYGGK GIKLTPTAKR ELAELERLGF 490 500 510 520 530 540 GNYPICMAKT QYSFSDDAKK LGAPTDFIVT ISNLKVSAGA GFIVALTGAI MTMPGLPKVP 550 ASETIDIDEE GNITGLF

References

[1]

"Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain." Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M. J. Infect. Dis. 190:727-738(2004) [PubMed: 15272401] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-946 / MGAS10394 / Serotype M6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000003 Genomic DNA. Translation: AAT87906.1.
RefSeq	YP_061089.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2941103.
GenomeReviews	Gene locus M6_Spy1771 in contig CP000003_GR.
KEGG	spa:M6_Spy1771.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5X9K7.
OMA	KMPGLPK.
Enzyme and pathway databases
BioCyc	SPYO286636:M6_SPY1771-MON.
BRENDA	6.3.4.3. 314561.
Family and domain databases
HAMAP	MF_01543. [Tree]
InterPro	IPR000559. For_THF_ligase. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS2_STRP6

Accession

Primary (citable) accession number: Q5X9K7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	November 23, 2004
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)