Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5X8H6

- YACG_LEGPA

UniProt

Q5X8H6 - YACG_LEGPA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

DNA gyrase inhibitor YacG

Gene

yacG

Organism
Legionella pneumophila (strain Paris)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.UniRule annotation

Cofactori

Binds 1 zinc ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91ZincUniRule annotation
Metal bindingi12 – 121ZincUniRule annotation
Metal bindingi28 – 281ZincUniRule annotation
Metal bindingi32 – 321ZincUniRule annotation

GO - Molecular functioni

  1. DNA topoisomerase (ATP-hydrolyzing) inhibitor activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciLPNE297246:GCO9-326-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA gyrase inhibitor YacGUniRule annotation
Gene namesi
Name:yacGUniRule annotation
Ordered Locus Names:lpp0275
OrganismiLegionella pneumophila (strain Paris)
Taxonomic identifieri297246 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000610: Chromosome

Organism-specific databases

LegioListilpp0275.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070DNA gyrase inhibitor YacGPRO_0000211703Add
BLAST

Interactioni

Subunit structurei

Interacts with GyrB.UniRule annotation

Protein-protein interaction databases

STRINGi297246.lpp0275.

Structurei

3D structure databases

ProteinModelPortaliQ5X8H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA gyrase inhibitor YacG family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3024.
HOGENOMiHOG000255917.
KOiK09862.
OMAiAWANERY.
OrthoDBiEOG65F8ZX.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
HAMAPiMF_00649. DNA_gyrase_inhibitor_YacG.
InterProiIPR005584. DNA_gyrase_inhibitor_YacG.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF03884. DUF329. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5X8H6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNQQKIKCP ICGKQNTWSP DNQFRPFCSE RCKLIDLGEW ASESRKIPGS
60 70
SIDPESIVTS NNKQDNEDEQ
Length:70
Mass (Da):8,015
Last modified:November 23, 2004 - v1
Checksum:i05502F6644477617
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628336 Genomic DNA. Translation: CAH11423.1.
RefSeqiYP_122617.1. NC_006368.1.

Genome annotation databases

EnsemblBacteriaiCAH11423; CAH11423; lpp0275.
GeneIDi3119541.
KEGGilpp:lpp0275.
PATRICi22320732. VBILegPne27771_0447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628336 Genomic DNA. Translation: CAH11423.1 .
RefSeqi YP_122617.1. NC_006368.1.

3D structure databases

ProteinModelPortali Q5X8H6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 297246.lpp0275.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH11423 ; CAH11423 ; lpp0275 .
GeneIDi 3119541.
KEGGi lpp:lpp0275.
PATRICi 22320732. VBILegPne27771_0447.

Organism-specific databases

LegioListi lpp0275.

Phylogenomic databases

eggNOGi COG3024.
HOGENOMi HOG000255917.
KOi K09862.
OMAi AWANERY.
OrthoDBi EOG65F8ZX.

Enzyme and pathway databases

BioCyci LPNE297246:GCO9-326-MONOMER.

Family and domain databases

Gene3Di 3.30.50.10. 1 hit.
HAMAPi MF_00649. DNA_gyrase_inhibitor_YacG.
InterProi IPR005584. DNA_gyrase_inhibitor_YacG.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF03884. DUF329. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
    Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
    Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Paris.

Entry informationi

Entry nameiYACG_LEGPA
AccessioniPrimary (citable) accession number: Q5X8H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 23, 2004
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3