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Protein

DNA gyrase inhibitor YacG

Gene

yacG

Organism
Legionella pneumophila (strain Paris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9ZincUniRule annotation1
Metal bindingi12ZincUniRule annotation1
Metal bindingi28ZincUniRule annotation1
Metal bindingi32ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA gyrase inhibitor YacGUniRule annotation
Gene namesi
Name:yacGUniRule annotation
Ordered Locus Names:lpp0275
OrganismiLegionella pneumophila (strain Paris)
Taxonomic identifieri297246 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

Organism-specific databases

LegioListilpp0275.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002117031 – 70DNA gyrase inhibitor YacGAdd BLAST70

Interactioni

Subunit structurei

Interacts with GyrB.UniRule annotation

Protein-protein interaction databases

STRINGi297246.lpp0275.

Structurei

3D structure databases

ProteinModelPortaliQ5X8H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA gyrase inhibitor YacG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41067SF. Bacteria.
COG3024. LUCA.
HOGENOMiHOG000255917.
KOiK09862.
OMAiGEWASES.
OrthoDBiPOG091H04DF.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
HAMAPiMF_00649. DNA_gyrase_inhibitor_YacG. 1 hit.
InterProiIPR005584. DNA_gyrase_inhibitor_YacG.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF03884. DUF329. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5X8H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNQQKIKCP ICGKQNTWSP DNQFRPFCSE RCKLIDLGEW ASESRKIPGS
60 70
SIDPESIVTS NNKQDNEDEQ
Length:70
Mass (Da):8,015
Last modified:November 23, 2004 - v1
Checksum:i05502F6644477617
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628336 Genomic DNA. Translation: CAH11423.1.
RefSeqiWP_011212901.1. NC_006368.1.

Genome annotation databases

EnsemblBacteriaiCAH11423; CAH11423; lpp0275.
KEGGilpp:lpp0275.
PATRICi22320732. VBILegPne27771_0447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628336 Genomic DNA. Translation: CAH11423.1.
RefSeqiWP_011212901.1. NC_006368.1.

3D structure databases

ProteinModelPortaliQ5X8H6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi297246.lpp0275.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH11423; CAH11423; lpp0275.
KEGGilpp:lpp0275.
PATRICi22320732. VBILegPne27771_0447.

Organism-specific databases

LegioListilpp0275.

Phylogenomic databases

eggNOGiENOG41067SF. Bacteria.
COG3024. LUCA.
HOGENOMiHOG000255917.
KOiK09862.
OMAiGEWASES.
OrthoDBiPOG091H04DF.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
HAMAPiMF_00649. DNA_gyrase_inhibitor_YacG. 1 hit.
InterProiIPR005584. DNA_gyrase_inhibitor_YacG.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF03884. DUF329. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYACG_LEGPA
AccessioniPrimary (citable) accession number: Q5X8H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.