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Protein

DNA gyrase inhibitor YacG

Gene

yacG

Organism
Legionella pneumophila (strain Paris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91ZincUniRule annotation
Metal bindingi12 – 121ZincUniRule annotation
Metal bindingi28 – 281ZincUniRule annotation
Metal bindingi32 – 321ZincUniRule annotation

GO - Molecular functioni

  1. DNA topoisomerase (ATP-hydrolyzing) inhibitor activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciLPNE297246:GCO9-326-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA gyrase inhibitor YacGUniRule annotation
Gene namesi
Name:yacGUniRule annotation
Ordered Locus Names:lpp0275
OrganismiLegionella pneumophila (strain Paris)
Taxonomic identifieri297246 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000610 Componenti: Chromosome

Organism-specific databases

LegioListilpp0275.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070DNA gyrase inhibitor YacGPRO_0000211703Add
BLAST

Interactioni

Subunit structurei

Interacts with GyrB.UniRule annotation

Protein-protein interaction databases

STRINGi297246.lpp0275.

Structurei

3D structure databases

ProteinModelPortaliQ5X8H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA gyrase inhibitor YacG family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3024.
HOGENOMiHOG000255917.
KOiK09862.
OMAiGEWASES.
OrthoDBiEOG65F8ZX.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
HAMAPiMF_00649. DNA_gyrase_inhibitor_YacG.
InterProiIPR005584. DNA_gyrase_inhibitor_YacG.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF03884. DUF329. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5X8H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNQQKIKCP ICGKQNTWSP DNQFRPFCSE RCKLIDLGEW ASESRKIPGS
60 70
SIDPESIVTS NNKQDNEDEQ
Length:70
Mass (Da):8,015
Last modified:November 22, 2004 - v1
Checksum:i05502F6644477617
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628336 Genomic DNA. Translation: CAH11423.1.
RefSeqiYP_122617.1. NC_006368.1.

Genome annotation databases

EnsemblBacteriaiCAH11423; CAH11423; lpp0275.
KEGGilpp:lpp0275.
PATRICi22320732. VBILegPne27771_0447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628336 Genomic DNA. Translation: CAH11423.1.
RefSeqiYP_122617.1. NC_006368.1.

3D structure databases

ProteinModelPortaliQ5X8H6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi297246.lpp0275.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH11423; CAH11423; lpp0275.
KEGGilpp:lpp0275.
PATRICi22320732. VBILegPne27771_0447.

Organism-specific databases

LegioListilpp0275.

Phylogenomic databases

eggNOGiCOG3024.
HOGENOMiHOG000255917.
KOiK09862.
OMAiGEWASES.
OrthoDBiEOG65F8ZX.

Enzyme and pathway databases

BioCyciLPNE297246:GCO9-326-MONOMER.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
HAMAPiMF_00649. DNA_gyrase_inhibitor_YacG.
InterProiIPR005584. DNA_gyrase_inhibitor_YacG.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF03884. DUF329. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
    Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
    Nat. Genet. 36:1165-1173(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Paris.

Entry informationi

Entry nameiYACG_LEGPA
AccessioniPrimary (citable) accession number: Q5X8H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2005
Last sequence update: November 22, 2004
Last modified: March 31, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.