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Q5X8H6

- YACG_LEGPA

UniProt

Q5X8H6 - YACG_LEGPA

Protein

DNA gyrase inhibitor YacG

Gene

yacG

Organism
Legionella pneumophila (strain Paris)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.UniRule annotation

    Cofactori

    Binds 1 zinc ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi9 – 91ZincUniRule annotation
    Metal bindingi12 – 121ZincUniRule annotation
    Metal bindingi28 – 281ZincUniRule annotation
    Metal bindingi32 – 321ZincUniRule annotation

    GO - Molecular functioni

    1. DNA topoisomerase (ATP-hydrolyzing) inhibitor activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciLPNE297246:GCO9-326-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA gyrase inhibitor YacGUniRule annotation
    Gene namesi
    Name:yacGUniRule annotation
    Ordered Locus Names:lpp0275
    OrganismiLegionella pneumophila (strain Paris)
    Taxonomic identifieri297246 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

    Organism-specific databases

    LegioListilpp0275.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7070DNA gyrase inhibitor YacGPRO_0000211703Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with GyrB.UniRule annotation

    Protein-protein interaction databases

    STRINGi297246.lpp0275.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5X8H6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA gyrase inhibitor YacG family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3024.
    HOGENOMiHOG000255917.
    KOiK09862.
    OMAiAWANERY.
    OrthoDBiEOG65F8ZX.

    Family and domain databases

    Gene3Di3.30.50.10. 1 hit.
    HAMAPiMF_00649. DNA_gyrase_inhibitor_YacG.
    InterProiIPR005584. DNA_gyrase_inhibitor_YacG.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF03884. DUF329. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Sequencei

    Sequence statusi: Complete.

    Q5X8H6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNQQKIKCP ICGKQNTWSP DNQFRPFCSE RCKLIDLGEW ASESRKIPGS   50
    SIDPESIVTS NNKQDNEDEQ 70
    Length:70
    Mass (Da):8,015
    Last modified:November 23, 2004 - v1
    Checksum:i05502F6644477617
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR628336 Genomic DNA. Translation: CAH11423.1.
    RefSeqiYP_122617.1. NC_006368.1.

    Genome annotation databases

    EnsemblBacteriaiCAH11423; CAH11423; lpp0275.
    GeneIDi3119541.
    KEGGilpp:lpp0275.
    PATRICi22320732. VBILegPne27771_0447.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR628336 Genomic DNA. Translation: CAH11423.1 .
    RefSeqi YP_122617.1. NC_006368.1.

    3D structure databases

    ProteinModelPortali Q5X8H6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 297246.lpp0275.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH11423 ; CAH11423 ; lpp0275 .
    GeneIDi 3119541.
    KEGGi lpp:lpp0275.
    PATRICi 22320732. VBILegPne27771_0447.

    Organism-specific databases

    LegioListi lpp0275.

    Phylogenomic databases

    eggNOGi COG3024.
    HOGENOMi HOG000255917.
    KOi K09862.
    OMAi AWANERY.
    OrthoDBi EOG65F8ZX.

    Enzyme and pathway databases

    BioCyci LPNE297246:GCO9-326-MONOMER.

    Family and domain databases

    Gene3Di 3.30.50.10. 1 hit.
    HAMAPi MF_00649. DNA_gyrase_inhibitor_YacG.
    InterProi IPR005584. DNA_gyrase_inhibitor_YacG.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF03884. DUF329. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
      Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
      Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Paris.

    Entry informationi

    Entry nameiYACG_LEGPA
    AccessioniPrimary (citable) accession number: Q5X8H6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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