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Q5X8E2 (GLSA_LEGPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutaminase

EC=3.5.1.2
Gene names
Name:glsA
Ordered Locus Names:lpp0311
OrganismLegionella pneumophila (strain Paris) [Complete proteome] [HAMAP]
Taxonomic identifier297246 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00313

Sequence similarities

Belongs to the glutaminase family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Glutaminase HAMAP-Rule MF_00313
PRO_1000079073

Sites

Binding site671Substrate By similarity
Binding site1181Substrate By similarity
Binding site1611Substrate By similarity
Binding site1681Substrate By similarity
Binding site1921Substrate By similarity
Binding site2441Substrate By similarity
Binding site2621Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5X8E2 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: D789C5F2878A8B89

FASTA31033,895
        10         20         30         40         50         60 
MSSKLLTIQL LEELVHAAEL NQEGKTADYI PELANVNQEL TAIAVQPLGE KTLAYSNNPL 

        70         80         90        100        110        120 
HPVTLQSTGK MIPLIGLLEE FGADQLFEWV KVEPSGDDFA SITRLEQFGP KPSNPMLNAG 

       130        140        150        160        170        180 
AIALCSRIPG VGEQQFRWLE HWVQKLFNQR LSINPLVFAS EKRTGNRNRA LAYLLKSRSN 

       190        200        210        220        230        240 
LGADVHETLD LYFALCSYEA MLDQMLYLPA VLANKGQDPD TGEQILSIET CKITLAIMAT 

       250        260        270        280        290        300 
CGLYDETGTH MVKTGMPAKS GVSGYTIAVV PGKAGIVVLS PRVNAKGNSI RGEIMLEGLS 

       310 
KAMNWHFALP 

« Hide

References

[1]"Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Paris.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR628336 Genomic DNA. Translation: CAH11459.1.
RefSeqYP_122651.1. NC_006368.1.

3D structure databases

ProteinModelPortalQ5X8E2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING297246.lpp0311.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH11459; CAH11459; lpp0311.
GeneID3118003.
KEGGlpp:lpp0311.
PATRIC22320806. VBILegPne27771_0484.

Organism-specific databases

LegioListlpp0311.
CMRSearch...

Phylogenomic databases

eggNOGCOG2066.
HOGENOMHOG000216890.
KOK01425.
OMAQRARRIN.
OrthoDBEOG6N94BK.

Enzyme and pathway databases

BioCycLPNE297246:GCO9-364-MONOMER.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
HAMAPMF_00313. Glutaminase.
InterProIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERPTHR12544. PTHR12544. 1 hit.
PfamPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
TIGRFAMsTIGR03814. Gln_ase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLSA_LEGPA
AccessionPrimary (citable) accession number: Q5X8E2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families