Reviewed, UniProtKB/Swiss-Prot Q5X748 (TDH_LEGPA)

Names and origin

Protein names

Recommended name:
    L-threonine 3-dehydrogenase
    EC=1.1.1.103

Gene names

Name:	tdh
Ordered Locus Names:	lpp0757

Organism

Legionella pneumophila (strain Paris) [Complete proteome] [HAMAP]

Taxonomic identifier

297246 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH. HAMAP MF_00627
Cofactor	Binds 2 zinc ions per subunit By similarity.
Pathway	Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. HAMAP MF_00627
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW threonine catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-threonine 3-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	L-threonine 3-dehydrogenase HAMAP MF_00627		PRO_0000160843
Sites
	Metal binding	38	1	Zinc 1; catalytic By similarity
	Metal binding	63	1	Zinc 1; catalytic By similarity
	Metal binding	93	1	Zinc 2 By similarity
	Metal binding	96	1	Zinc 2 By similarity
	Metal binding	99	1	Zinc 2 By similarity
	Metal binding	107	1	Zinc 2 By similarity
	Metal binding	148	1	Zinc 1; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5X748-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 5D311E3E254F75E1	FASTA	340	37,236
	10 20 30 40 50 60 MKSLVKAKKE PGIWMQDIPV PEYGVNDVLI KIKRTAICGT DIHIYSWDEW AQATIPVPMT 70 80 90 100 110 120 VGHEFYGEIV EVGKEVQGLK VGQRVSGEGH ITCGFCRNCR AGKRHLCRNT LGVGVNRPGC 130 140 150 160 170 180 FAEYLALPAT NVIALPDNIT EEQAAILDPF GNAAHCALAF DVVGEDVLIT GAGPIGIMAA 190 200 210 220 230 240 AIVRHIGARH VVITDVNDHR LELARQMGVS RAVNVKYQKL IDVANELGML EGFDVGLEMS 250 260 270 280 290 300 GNPMALNDMM KAMNHGGHVA LLGIPPQETP IDWNQVIFKG LVIKGIYGRE MFETWYKMIA 310 320 330 340 MLQSGLNISP VITHNFPVDE YQHAFQIMAS GQSGKVILNW

References

[1]

"Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity." Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C. Nat. Genet. 36:1165-1173(2004) [PubMed: 15467720] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR628336 Genomic DNA. Translation: CAH11905.1.
RefSeq	YP_123095.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5X748.
Genome annotation databases
GeneID	3116557.
GenomeReviews	Gene locus lpp0757 in contig CR628336_GR.
KEGG	lpp:lpp0757.
Organism-specific databases
LegioList	lpp0757.
CMR	Search...
Phylogenomic databases
HOGENOM	Q5X748.
OMA	FKAITIK.
Enzyme and pathway databases
BioCyc	LPNE297246:LPP0757-MON.
Family and domain databases
HAMAP	MF_00627. [Tree]
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR002328. ADH_Zn_CS. IPR004627. L-Threonine_3-DHase. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00692. tdh. 1 hit.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TDH_LEGPA

Accession

Primary (citable) accession number: Q5X748

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	November 23, 2004
Last modified:	November 3, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)