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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Legionella pneumophila (strain Paris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciLPNE297246:GCO9-1142-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:lpp0888
OrganismiLegionella pneumophila (strain Paris)
Taxonomic identifieri297246 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

Organism-specific databases

LegioListilpp0888.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Exodeoxyribonuclease 7 large subunitPRO_0000273668Add
BLAST

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

STRINGi297246.lpp0888.

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229265.
KOiK03601.
OMAiVVFRQRD.
OrthoDBiEOG64R65J.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR012340. NA-bd_OB-fold.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5X6S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQLPILTV SQLNRQVKGF LENEIGLVHV EGEISNLSKP SSGHYYFTLK
60 70 80 90 100
DSTAQIRCAF FKNRHSNSLL RNFNDGQQIV ATGKLSLYEA RGEYQLIVEE
110 120 130 140 150
IVKAGMGILY QRFEELKIKL ASEGLFNPER KKPLPRIPET IGIITSPTGA
160 170 180 190 200
AIQDILSTLA RRFPIARIII YPSEVQGQTA PQQLVKALKL ANAHKRCQVL
210 220 230 240 250
ILARGGGSIE DLWAFNDEYL ARQIAISEIP VVSGIGHETD FTIADFVADY
260 270 280 290 300
RAETPTAAAT AVTPNCIELF NILDTAIYRL HDAIIRLVKG LQLKLNHLID
310 320 330 340 350
KIASPRQTIS TYWQTLDYLE RQLISAMTQF INLNINKVNI FSTQLQANNP
360 370 380 390 400
KTQIERTKTQ LRQLIMQLNQ EIRIQVNQLK NQLSTNLSTL HAVSPLATLD
410 420 430 440
RGYAIVSKNQ RILFAAQQAQ IGDTIDVRLA KGSLACEVTQ IKD
Length:443
Mass (Da):49,571
Last modified:November 23, 2004 - v1
Checksum:iB26DAC411495415D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628336 Genomic DNA. Translation: CAH12039.1.
RefSeqiWP_010946562.1. NC_006368.1.

Genome annotation databases

EnsemblBacteriaiCAH12039; CAH12039; lpp0888.
KEGGilpp:lpp0888.
PATRICi22322065. VBILegPne27771_1096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628336 Genomic DNA. Translation: CAH12039.1.
RefSeqiWP_010946562.1. NC_006368.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi297246.lpp0888.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH12039; CAH12039; lpp0888.
KEGGilpp:lpp0888.
PATRICi22322065. VBILegPne27771_1096.

Organism-specific databases

LegioListilpp0888.

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229265.
KOiK03601.
OMAiVVFRQRD.
OrthoDBiEOG64R65J.

Enzyme and pathway databases

BioCyciLPNE297246:GCO9-1142-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR012340. NA-bd_OB-fold.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
    Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
    Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Paris.

Entry informationi

Entry nameiEX7L_LEGPA
AccessioniPrimary (citable) accession number: Q5X6S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 23, 2004
Last modified: November 11, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.