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Q5X5W9

- HISX_LEGPA

UniProt

Q5X5W9 - HISX_LEGPA

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Legionella pneumophila (strain Paris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei124 – 1241NADUniRule annotation
    Binding sitei187 – 1871NADUniRule annotation
    Binding sitei210 – 2101NADUniRule annotation
    Binding sitei236 – 2361SubstrateUniRule annotation
    Metal bindingi258 – 2581ZincUniRule annotation
    Binding sitei258 – 2581SubstrateUniRule annotation
    Metal bindingi261 – 2611ZincUniRule annotation
    Binding sitei261 – 2611SubstrateUniRule annotation
    Active sitei325 – 3251Proton acceptorUniRule annotation
    Active sitei326 – 3261Proton acceptorUniRule annotation
    Binding sitei326 – 3261SubstrateUniRule annotation
    Metal bindingi359 – 3591ZincUniRule annotation
    Binding sitei359 – 3591SubstrateUniRule annotation
    Binding sitei413 – 4131SubstrateUniRule annotation
    Metal bindingi418 – 4181ZincUniRule annotation
    Binding sitei418 – 4181SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:lpp1201
    OrganismiLegionella pneumophila (strain Paris)
    Taxonomic identifieri297246 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000000610: Chromosome

    Organism-specific databases

    LegioListilpp1201.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Histidinol dehydrogenasePRO_0000135785Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi297246.lpp1201.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5X5W9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5X5W9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTIKNWQLL SDNDKRRCLS RPRDNSAIKE NVLEIINQVQ LSGDKALYDL    50
    TKRFDRVNLQ YLQISQEKIR QASIPQNALI AIKQAIETIS SYHQFLLPEN 100
    TEISTASGIT IRNVYRPIQK VGLYVPGGNK TPLVSSLLMQ AIPAKVAGCP 150
    IKVLCTPPDA EGEINEHILV AARLCGIDTI YAIGGAQAIA AMAYGTESVI 200
    KVDKIFGPGN SYVTQAKTLV AIDADGAAID MPAGPSEVMI LADTEANPEF 250
    IAADLLAQAE HGPDSQVILI CDECELANQV NQQLEIQMSY LSRIEFIKQS 300
    LTNSRIIICS NQSEQLDIIN SYAPEHLIIN RKNPEPWVEK IVAAGTVFLG 350
    SWAAETMGDY VTGSNHVLPT SGFARNHSGL STLDFMTRFT VQAINQEAIR 400
    NLGPAAMTLA ELEGLDAHAN AVQIRLNTLG D 431
    Length:431
    Mass (Da):46,978
    Last modified:November 23, 2004 - v1
    Checksum:iC62D04CAF0C02A2D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR628336 Genomic DNA. Translation: CAH12352.1.
    RefSeqiYP_123525.1. NC_006368.1.

    Genome annotation databases

    EnsemblBacteriaiCAH12352; CAH12352; lpp1201.
    GeneIDi3118544.
    KEGGilpp:lpp1201.
    PATRICi22322747. VBILegPne27771_1434.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR628336 Genomic DNA. Translation: CAH12352.1 .
    RefSeqi YP_123525.1. NC_006368.1.

    3D structure databases

    ProteinModelPortali Q5X5W9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 297246.lpp1201.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH12352 ; CAH12352 ; lpp1201 .
    GeneIDi 3118544.
    KEGGi lpp:lpp1201.
    PATRICi 22322747. VBILegPne27771_1434.

    Organism-specific databases

    LegioListi lpp1201.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
      Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
      Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Paris.

    Entry informationi

    Entry nameiHISX_LEGPA
    AccessioniPrimary (citable) accession number: Q5X5W9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3