Reviewed, UniProtKB/Swiss-Prot Q5X5S2 (HGD_LEGPA)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	lpp1248

Organism

Legionella pneumophila (strain Paris) [Complete proteome] [HAMAP]

Taxonomic identifier

297246 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334
Cofactor	Iron By similarity. HAMAP MF_00334
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Homogentisate 1,2-dioxygenase HAMAP MF_00334		PRO_0000225790
Sites
	Metal binding	318	1	Iron By similarity
	Metal binding	324	1	Iron By similarity
	Metal binding	354	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5X5S2-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 2A4D511B622A974D	FASTA	416	47,433
	10 20 30 40 50 60 MYLQGFGNYH HSEAVKGALP TNQNSPQHCS LGLYAEQLSG TSFTRPRHNN LRSWLYRILP 70 80 90 100 110 120 TVTQGTYYPY EFNVMQPFVD ELSPNAMRWS PLYNSSQIKC DFVEGLFHIA GSPLVNTYTY 130 140 150 160 170 180 YCNHSMSDKY FANNDGELLF VPYAGEIHLH TEFGKLILSS GSIAVIPRGV KFKVEVISKE 190 200 210 220 230 240 AKGYLCENSG NPLTLPQLGP IGANGLANPR HFQYPVAAFE NSGGEHTIIC KNQKKLWFTV 250 260 270 280 290 300 CNHSPLNVVA WHGNYAPYCY DLSLFNTINT VSFDHPDPSI FTVLTSESEI PGVSNLDFVI 310 320 330 340 350 360 FPPRWMVAEH TFRPPYFHRN YMNELMGLVY GEYDAKKEGF IPGGISIHNC MTPHGPDYES 370 380 390 400 410 YEIAASQDLK PNYINSLAFM FETKDYWQVT EQAYRHPSRQ MDYLNCWQGF KIEFSQ

References

[1]

"Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity." Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C. Nat. Genet. 36:1165-1173(2004) [PubMed: 15467720] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR628336 Genomic DNA. Translation: CAH12399.1.
RefSeq	YP_123572.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5X5S2.
Genome annotation databases
GeneID	3117133.
GenomeReviews	Gene locus lpp1248 in contig CR628336_GR.
KEGG	lpp:lpp1248.
Organism-specific databases
LegioList	lpp1248.
CMR	Search...
Phylogenomic databases
eggNOG	COG3508.
HOGENOM	HBG293508.
OMA	RNCMSEF.
Enzyme and pathway databases
BioCyc	LPNE297246:LPP1248-MONOMER.
Family and domain databases
HAMAP	MF_00334. Homogentis_dioxygen. [Tree]
InterPro	IPR011051. Cupin_RmlC_type. IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_LEGPA

Accession

Primary (citable) accession number: Q5X5S2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	November 23, 2004
Last modified:	February 9, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)