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Protein

Lipid-A-disaccharide synthase 1

Gene

lpxB1

Organism
Legionella pneumophila (strain Paris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciLPNE297246:GCO9-1691-MONOMER.
BRENDAi2.4.1.182. 2943.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase 1UniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxB1UniRule annotation
Ordered Locus Names:lpp1325
OrganismiLegionella pneumophila (strain Paris)
Taxonomic identifieri297246 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000610 Componenti: Chromosome

Organism-specific databases

LegioListilpp1325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Lipid-A-disaccharide synthase 1PRO_0000255192Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi297246.lpp1325.

Structurei

3D structure databases

ProteinModelPortaliQ5X5J5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiIARMLVN.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5X5J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNASRVVIV AGEESGDHHA AELVKQLKAV YPNLKISGIG GKHLRAAGVH
60 70 80 90 100
LISDLTRYAV TGLTEIIPFL KIFHKAFQDI KQHLSTQKPD LLILVDYPAF
110 120 130 140 150
NLRLAKYAKK KLGLKIIYYI SPQIWAWKGK RIHLIKDSID KMAVIFPFEK
160 170 180 190 200
TIYENAGVPV SFVGHPLVKK IASAKDKHSS RTFLGLPLDE PIIALLPGSR
210 220 230 240 250
HSEIERHIPI LVNTAKLLTL DNPKLRFVVP IAGTINPDKV KAYFSNQNLT
260 270 280 290 300
VTFIQGQAIE CMSAADFVIV ASGTASLECA LLEKPMCIIY KSSFLTYVAA
310 320 330 340 350
MYFIKVKFLG LCNLLANKMM VPEFLQYDCN EIELSRYISN FHSDPNQPKS
360 370 380
MINQLAKLKE SLSSSQADCS LFDLVVAELP EKNA
Length:384
Mass (Da):42,761
Last modified:November 22, 2004 - v1
Checksum:i00BDB82CDA3FC24C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628336 Genomic DNA. Translation: CAH12476.1.
RefSeqiYP_123649.1. NC_006368.1.

Genome annotation databases

EnsemblBacteriaiCAH12476; CAH12476; lpp1325.
KEGGilpp:lpp1325.
PATRICi22323019. VBILegPne27771_1568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628336 Genomic DNA. Translation: CAH12476.1.
RefSeqiYP_123649.1. NC_006368.1.

3D structure databases

ProteinModelPortaliQ5X5J5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi297246.lpp1325.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH12476; CAH12476; lpp1325.
KEGGilpp:lpp1325.
PATRICi22323019. VBILegPne27771_1568.

Organism-specific databases

LegioListilpp1325.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiIARMLVN.
OrthoDBiEOG6FBWZR.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.
BioCyciLPNE297246:GCO9-1691-MONOMER.
BRENDAi2.4.1.182. 2943.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
    Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
    Nat. Genet. 36:1165-1173(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Paris.

Entry informationi

Entry nameiLPXB1_LEGPA
AccessioniPrimary (citable) accession number: Q5X5J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 30, 2006
Last sequence update: November 22, 2004
Last modified: March 31, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.