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Q5X5J5

- LPXB1_LEGPA

UniProt

Q5X5J5 - LPXB1_LEGPA

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Protein

Lipid-A-disaccharide synthase 1

Gene
lpxB1, lpp1325
Organism
Legionella pneumophila (strain Paris)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciLPNE297246:GCO9-1691-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase 1 (EC:2.4.1.182)
Gene namesi
Name:lpxB1
Ordered Locus Names:lpp1325
OrganismiLegionella pneumophila (strain Paris)
Taxonomic identifieri297246 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000610: Chromosome

Organism-specific databases

LegioListilpp1325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Lipid-A-disaccharide synthase 1UniRule annotationPRO_0000255192Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi297246.lpp1325.

Structurei

3D structure databases

ProteinModelPortaliQ5X5J5.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiTIYENAG.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5X5J5-1 [UniParc]FASTAAdd to Basket

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MPNASRVVIV AGEESGDHHA AELVKQLKAV YPNLKISGIG GKHLRAAGVH    50
LISDLTRYAV TGLTEIIPFL KIFHKAFQDI KQHLSTQKPD LLILVDYPAF 100
NLRLAKYAKK KLGLKIIYYI SPQIWAWKGK RIHLIKDSID KMAVIFPFEK 150
TIYENAGVPV SFVGHPLVKK IASAKDKHSS RTFLGLPLDE PIIALLPGSR 200
HSEIERHIPI LVNTAKLLTL DNPKLRFVVP IAGTINPDKV KAYFSNQNLT 250
VTFIQGQAIE CMSAADFVIV ASGTASLECA LLEKPMCIIY KSSFLTYVAA 300
MYFIKVKFLG LCNLLANKMM VPEFLQYDCN EIELSRYISN FHSDPNQPKS 350
MINQLAKLKE SLSSSQADCS LFDLVVAELP EKNA 384
Length:384
Mass (Da):42,761
Last modified:November 23, 2004 - v1
Checksum:i00BDB82CDA3FC24C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628336 Genomic DNA. Translation: CAH12476.1.
RefSeqiYP_123649.1. NC_006368.1.

Genome annotation databases

EnsemblBacteriaiCAH12476; CAH12476; lpp1325.
GeneIDi3119020.
KEGGilpp:lpp1325.
PATRICi22323019. VBILegPne27771_1568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628336 Genomic DNA. Translation: CAH12476.1 .
RefSeqi YP_123649.1. NC_006368.1.

3D structure databases

ProteinModelPortali Q5X5J5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 297246.lpp1325.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH12476 ; CAH12476 ; lpp1325 .
GeneIDi 3119020.
KEGGi lpp:lpp1325.
PATRICi 22323019. VBILegPne27771_1568.

Organism-specific databases

LegioListi lpp1325.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi TIYENAG.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci LPNE297246:GCO9-1691-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
    Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
    Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Paris.

Entry informationi

Entry nameiLPXB1_LEGPA
AccessioniPrimary (citable) accession number: Q5X5J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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