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Q5X4E4

- LFTR_LEGPA

UniProt

Q5X4E4 - LFTR_LEGPA

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Protein

Leucyl/phenylalanyl-tRNA--protein transferase

Gene

aat

Organism
Legionella pneumophila (strain Paris)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.UniRule annotation

Catalytic activityi

L-leucyl-tRNA(Leu) + [protein] = tRNA(Leu) + L-leucyl-[protein].UniRule annotation
L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation

GO - Molecular functioni

  1. leucyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciLPNE297246:GCO9-2243-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation (EC:2.3.2.6UniRule annotation)
Alternative name(s):
L/F-transferaseUniRule annotation
LeucyltransferaseUniRule annotation
PhenyalanyltransferaseUniRule annotation
Gene namesi
Name:aatUniRule annotation
Ordered Locus Names:lpp1732
OrganismiLegionella pneumophila (strain Paris)
Taxonomic identifieri297246 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000610: Chromosome

Organism-specific databases

LegioListilpp1732.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Leucyl/phenylalanyl-tRNA--protein transferasePRO_0000207223Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi297246.lpp1732.

Structurei

3D structure databases

ProteinModelPortaliQ5X4E4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L/F-transferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2360.
HOGENOMiHOG000102325.
KOiK00684.
OMAiWSPDPRG.
OrthoDBiEOG6WX4R3.

Family and domain databases

HAMAPiMF_00688. Leu_Phe_trans.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view]
PfamiPF03588. Leu_Phe_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00667. aat. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5X4E4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYDSDYTFP DPETSDKQGL LAIGGVLTPK RVLQAYSQGI FPWYEPGNPV
60 70 80 90 100
LWWSPNPRLI LIPNEFKISR SLKKTLKKPF KLTVDTAFQR VISYCATCSD
110 120 130 140 150
RTNKTWITSE MIETYTQLHE MGYAHSFEIW DGSELVGGLY GISLGHAFFG
160 170 180 190 200
ESMFHTITDA SKVALHFLCS IMQSWNFDFI DCQLPTLHLM RLGAKIISRK
210 220
EFLHMLQETL KYPDKKGNWS VD
Length:222
Mass (Da):25,474
Last modified:November 23, 2004 - v1
Checksum:iBBB70BE39AF87BCE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628336 Genomic DNA. Translation: CAH12884.1.
RefSeqiYP_124050.1. NC_006368.1.

Genome annotation databases

EnsemblBacteriaiCAH12884; CAH12884; lpp1732.
GeneIDi3116693.
KEGGilpp:lpp1732.
PATRICi22323891. VBILegPne27771_2001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628336 Genomic DNA. Translation: CAH12884.1 .
RefSeqi YP_124050.1. NC_006368.1.

3D structure databases

ProteinModelPortali Q5X4E4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 297246.lpp1732.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH12884 ; CAH12884 ; lpp1732 .
GeneIDi 3116693.
KEGGi lpp:lpp1732.
PATRICi 22323891. VBILegPne27771_2001.

Organism-specific databases

LegioListi lpp1732.

Phylogenomic databases

eggNOGi COG2360.
HOGENOMi HOG000102325.
KOi K00684.
OMAi WSPDPRG.
OrthoDBi EOG6WX4R3.

Enzyme and pathway databases

BioCyci LPNE297246:GCO9-2243-MONOMER.

Family and domain databases

HAMAPi MF_00688. Leu_Phe_trans.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view ]
Pfami PF03588. Leu_Phe_trans. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR00667. aat. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
    Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
    Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Paris.

Entry informationi

Entry nameiLFTR_LEGPA
AccessioniPrimary (citable) accession number: Q5X4E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3