Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5X2M8

- TYPH_LEGPA

UniProt

Q5X2M8 - TYPH_LEGPA

Protein

Putative thymidine phosphorylase

Gene

lpp2359

Organism
Legionella pneumophila (strain Paris)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. thymidine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pyrimidine nucleobase metabolic process Source: InterPro
    2. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciLPNE297246:GCO9-3041-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
    Alternative name(s):
    TdRPaseUniRule annotation
    Gene namesi
    Ordered Locus Names:lpp2359
    OrganismiLegionella pneumophila (strain Paris)
    Taxonomic identifieri297246 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000000610: Chromosome

    Organism-specific databases

    LegioListilpp2359.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Putative thymidine phosphorylasePRO_0000225646Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi297246.lpp2359.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5X2M8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OMAiESVPGFH.
    OrthoDBiEOG61ZTGG.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_00703. Thymid_phosp_2.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5X2M8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHHSFLSANG GIVVSKQTSH GLRLKHLGIK TYHEAIIYMR EDCHVCHSEG    50
    FEVQTRIQVT LGQRSIIATL NVVTSELLQP GEAGLSDYAW ESLHAKEGDE 100
    IQVSHPKPLE SLSYVHTKIY GKELSYEQMK VIIDDVLSGR LSDVQISAFL 150
    AASSAGRLTR TEIMKLTKAM IDSGDRLSWS SPLVVDKHCV GGLPGNRTTL 200
    IVVPIVAAFG LMIPKTSSRA ITSPAGTADT METLAPVHLS PQKMRQVVEQ 250
    ENGCIVWGGA VSLSPADDVL IRVERAIDLD SEGQLVASIL SKKIATGATH 300
    AVIDIPVGPT AKVRNQSMAL LLKQLLEEVG NELGLVVRTL LTDGSQPVGH 350
    GIGPSLEARD VMAVLQGLPD APNDLRERAL TLAGAALECS SKVPPGLGKS 400
    IATQLLDSGQ AFKKFQAICE AQGGMRELTK ARFTYPVVAA KAGKVSLIDN 450
    RKLAKIAKLA GAPKSKSAGI DLHSHVGESV EKGEPLFTIH SESSGELHYA 500
    CDLLRDKQDI IILGENS 517
    Length:517
    Mass (Da):55,341
    Last modified:November 23, 2004 - v1
    Checksum:i71830C78AF8F000E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR628336 Genomic DNA. Translation: CAH13512.1.
    RefSeqiYP_124670.1. NC_006368.1.

    Genome annotation databases

    EnsemblBacteriaiCAH13512; CAH13512; lpp2359.
    GeneIDi3119477.
    KEGGilpp:lpp2359.
    PATRICi22325297. VBILegPne27771_2686.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR628336 Genomic DNA. Translation: CAH13512.1 .
    RefSeqi YP_124670.1. NC_006368.1.

    3D structure databases

    ProteinModelPortali Q5X2M8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 297246.lpp2359.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH13512 ; CAH13512 ; lpp2359 .
    GeneIDi 3119477.
    KEGGi lpp:lpp2359.
    PATRICi 22325297. VBILegPne27771_2686.

    Organism-specific databases

    LegioListi lpp2359.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OMAi ESVPGFH.
    OrthoDBi EOG61ZTGG.

    Enzyme and pathway databases

    BioCyci LPNE297246:GCO9-3041-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_00703. Thymid_phosp_2.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
      Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
      Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Paris.

    Entry informationi

    Entry nameiTYPH_LEGPA
    AccessioniPrimary (citable) accession number: Q5X2M8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3