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Q5X2M8

- TYPH_LEGPA

UniProt

Q5X2M8 - TYPH_LEGPA

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Protein

Putative thymidine phosphorylase

Gene

lpp2359

Organism
Legionella pneumophila (strain Paris)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. thymidine phosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyrimidine nucleobase metabolic process Source: InterPro
  2. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciLPNE297246:GCO9-3041-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Ordered Locus Names:lpp2359
OrganismiLegionella pneumophila (strain Paris)
Taxonomic identifieri297246 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000610: Chromosome

Organism-specific databases

LegioListilpp2359.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Putative thymidine phosphorylasePRO_0000225646Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi297246.lpp2359.

Structurei

3D structure databases

ProteinModelPortaliQ5X2M8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiESVPGFH.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_00703. Thymid_phosp_2.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5X2M8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHHSFLSANG GIVVSKQTSH GLRLKHLGIK TYHEAIIYMR EDCHVCHSEG
60 70 80 90 100
FEVQTRIQVT LGQRSIIATL NVVTSELLQP GEAGLSDYAW ESLHAKEGDE
110 120 130 140 150
IQVSHPKPLE SLSYVHTKIY GKELSYEQMK VIIDDVLSGR LSDVQISAFL
160 170 180 190 200
AASSAGRLTR TEIMKLTKAM IDSGDRLSWS SPLVVDKHCV GGLPGNRTTL
210 220 230 240 250
IVVPIVAAFG LMIPKTSSRA ITSPAGTADT METLAPVHLS PQKMRQVVEQ
260 270 280 290 300
ENGCIVWGGA VSLSPADDVL IRVERAIDLD SEGQLVASIL SKKIATGATH
310 320 330 340 350
AVIDIPVGPT AKVRNQSMAL LLKQLLEEVG NELGLVVRTL LTDGSQPVGH
360 370 380 390 400
GIGPSLEARD VMAVLQGLPD APNDLRERAL TLAGAALECS SKVPPGLGKS
410 420 430 440 450
IATQLLDSGQ AFKKFQAICE AQGGMRELTK ARFTYPVVAA KAGKVSLIDN
460 470 480 490 500
RKLAKIAKLA GAPKSKSAGI DLHSHVGESV EKGEPLFTIH SESSGELHYA
510
CDLLRDKQDI IILGENS
Length:517
Mass (Da):55,341
Last modified:November 23, 2004 - v1
Checksum:i71830C78AF8F000E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628336 Genomic DNA. Translation: CAH13512.1.
RefSeqiWP_015961486.1. NC_006368.1.
YP_124670.1. NC_006368.1.

Genome annotation databases

EnsemblBacteriaiCAH13512; CAH13512; lpp2359.
GeneIDi3119477.
KEGGilpp:lpp2359.
PATRICi22325297. VBILegPne27771_2686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628336 Genomic DNA. Translation: CAH13512.1 .
RefSeqi WP_015961486.1. NC_006368.1.
YP_124670.1. NC_006368.1.

3D structure databases

ProteinModelPortali Q5X2M8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 297246.lpp2359.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH13512 ; CAH13512 ; lpp2359 .
GeneIDi 3119477.
KEGGi lpp:lpp2359.
PATRICi 22325297. VBILegPne27771_2686.

Organism-specific databases

LegioListi lpp2359.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.
OMAi ESVPGFH.
OrthoDBi EOG61ZTGG.

Enzyme and pathway databases

BioCyci LPNE297246:GCO9-3041-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_00703. Thymid_phosp_2.
InterProi IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
    Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
    Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Paris.

Entry informationi

Entry nameiTYPH_LEGPA
AccessioniPrimary (citable) accession number: Q5X2M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3