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Q5X0T2

- LPXB2_LEGPA

UniProt

Q5X0T2 - LPXB2_LEGPA

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Protein

Lipid-A-disaccharide synthase 2

Gene
lpxB2, lpp3014
Organism
Legionella pneumophila (strain Paris)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciLPNE297246:GCO9-3819-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase 2 (EC:2.4.1.182)
Gene namesi
Name:lpxB2
Ordered Locus Names:lpp3014
OrganismiLegionella pneumophila (strain Paris)
Taxonomic identifieri297246 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000610: Chromosome

Organism-specific databases

LegioListilpp3014.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Lipid-A-disaccharide synthase 2UniRule annotationPRO_0000255193Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi297246.lpp3014.

Structurei

3D structure databases

ProteinModelPortaliQ5X0T2.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiEWTINPP.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5X0T2-1 [UniParc]FASTAAdd to Basket

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MIKEKRLRIA MVAGELSGDL LGAGVIRELK QHLTNVEFMG VGGPQMLKEG    50
FHSLIDISEL SVMGISDVLR RYPQLYLIRE RLLREWTINP PDVFIGIDYP 100
DFNLSVEARL KKQHIKTIHL VSPKVWAWRQ KRVHLIKKAV DLVLTLFPFE 150
EAFYLQHGVS AQFIGHPLAD LIEINPSCSA LRKKYNYHSD DTILAVLPGS 200
RVGEIKYMGP LFLEVMQRIA MERPHVHFIV PIACQDLYPV FFKQLHAEYD 250
YLKIQVIQGN AREAMAISDV VLTKSGTATL EAMLLKRPMV VAFKWGILTH 300
AIIAPQVKVP YIALPNLLAG KKLIPEFVQE KANVDSITES VLNLLDSSNQ 350
NELIKQFTDI HRTLRQNANE KAALAILRIL EDSLT 385
Length:385
Mass (Da):43,681
Last modified:November 23, 2004 - v1
Checksum:i53F65F52047322C3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628336 Genomic DNA. Translation: CAH14167.1.
RefSeqiYP_125316.1. NC_006368.1.

Genome annotation databases

EnsemblBacteriaiCAH14167; CAH14167; lpp3014.
GeneIDi3116463.
KEGGilpp:lpp3014.
PATRICi22326773. VBILegPne27771_3416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628336 Genomic DNA. Translation: CAH14167.1 .
RefSeqi YP_125316.1. NC_006368.1.

3D structure databases

ProteinModelPortali Q5X0T2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 297246.lpp3014.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH14167 ; CAH14167 ; lpp3014 .
GeneIDi 3116463.
KEGGi lpp:lpp3014.
PATRICi 22326773. VBILegPne27771_3416.

Organism-specific databases

LegioListi lpp3014.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi EWTINPP.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci LPNE297246:GCO9-3819-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
    Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
    Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Paris.

Entry informationi

Entry nameiLPXB2_LEGPA
AccessioniPrimary (citable) accession number: Q5X0T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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