Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5X0T2

- LPXB2_LEGPA

UniProt

Q5X0T2 - LPXB2_LEGPA

Protein

Lipid-A-disaccharide synthase 2

Gene

lpxB2

Organism
Legionella pneumophila (strain Paris)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciLPNE297246:GCO9-3819-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase 2UniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxB2UniRule annotation
    Ordered Locus Names:lpp3014
    OrganismiLegionella pneumophila (strain Paris)
    Taxonomic identifieri297246 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000000610: Chromosome

    Organism-specific databases

    LegioListilpp3014.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 385385Lipid-A-disaccharide synthase 2PRO_0000255193Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi297246.lpp3014.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5X0T2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiEWTINPP.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5X0T2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKEKRLRIA MVAGELSGDL LGAGVIRELK QHLTNVEFMG VGGPQMLKEG    50
    FHSLIDISEL SVMGISDVLR RYPQLYLIRE RLLREWTINP PDVFIGIDYP 100
    DFNLSVEARL KKQHIKTIHL VSPKVWAWRQ KRVHLIKKAV DLVLTLFPFE 150
    EAFYLQHGVS AQFIGHPLAD LIEINPSCSA LRKKYNYHSD DTILAVLPGS 200
    RVGEIKYMGP LFLEVMQRIA MERPHVHFIV PIACQDLYPV FFKQLHAEYD 250
    YLKIQVIQGN AREAMAISDV VLTKSGTATL EAMLLKRPMV VAFKWGILTH 300
    AIIAPQVKVP YIALPNLLAG KKLIPEFVQE KANVDSITES VLNLLDSSNQ 350
    NELIKQFTDI HRTLRQNANE KAALAILRIL EDSLT 385
    Length:385
    Mass (Da):43,681
    Last modified:November 23, 2004 - v1
    Checksum:i53F65F52047322C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR628336 Genomic DNA. Translation: CAH14167.1.
    RefSeqiYP_125316.1. NC_006368.1.

    Genome annotation databases

    EnsemblBacteriaiCAH14167; CAH14167; lpp3014.
    GeneIDi3116463.
    KEGGilpp:lpp3014.
    PATRICi22326773. VBILegPne27771_3416.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR628336 Genomic DNA. Translation: CAH14167.1 .
    RefSeqi YP_125316.1. NC_006368.1.

    3D structure databases

    ProteinModelPortali Q5X0T2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 297246.lpp3014.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH14167 ; CAH14167 ; lpp3014 .
    GeneIDi 3116463.
    KEGGi lpp:lpp3014.
    PATRICi 22326773. VBILegPne27771_3416.

    Organism-specific databases

    LegioListi lpp3014.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi EWTINPP.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci LPNE297246:GCO9-3819-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
      Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
      Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Paris.

    Entry informationi

    Entry nameiLPXB2_LEGPA
    AccessioniPrimary (citable) accession number: Q5X0T2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3