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Q5X0A6

- GCSPA_LEGPL

UniProt

Q5X0A6 - GCSPA_LEGPL

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Legionella pneumophila (strain Lens)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciLPNE297245:GJD4-119-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:lpl0115
OrganismiLegionella pneumophila (strain Lens)
Taxonomic identifieri297245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000002517: Chromosome

Organism-specific databases

LegioListilpl0115.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045663Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi297245.lpl0115.

Structurei

3D structure databases

ProteinModelPortaliQ5X0A6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiGLEVANC.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5X0A6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPYIPHTPND TKEMLAAIGA QDIQDLFDEI PASLQYAGFQ NIPAGINEME
60 70 80 90 100
MLKEAQNQAQ KNRNGICFIG AGCYEHHIPA AVWDIASRGE FLTAYTPYQA
110 120 130 140 150
EASQGTLQLL YEYQTMICEL TGMEVSNASM YDGATALAEA VLMAVRLNKH
160 170 180 190 200
SKTNRVLIAG TVHPFYRETI ETIVRNQHIE VITLPFDEQQ GITDLGSLNQ
210 220 230 240 250
YTGEDITALV IAQPNFFGCL EQVDKMTSWA HHNKTISVAC INPTSLALLK
260 270 280 290 300
PPGSWGEHGV DIVCGEGQPL GSPMASGGPY FGFLSTRMAH VRQMPGRIIG
310 320 330 340 350
RTVDKDGKTG FSLTLQAREQ HIRRAKATSN ICTNQGLLVT AATIYMSLLG
360 370 380 390 400
PEGLSQVATQ CHQNTHELIT ALTQIEGVEQ AFKASFFHEA LIKLNQPVQS
410 420 430 440 450
VLQQLADAGI AGGYAPEQHY PQLANTLLVC ATEVRTAEDI AKYAKTLKAI

MSKRGA
Length:456
Mass (Da):49,752
Last modified:November 23, 2004 - v1
Checksum:i6444EC0562C0BC1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628337 Genomic DNA. Translation: CAH14345.1.
RefSeqiWP_011214399.1. NC_006369.1.
YP_125492.1. NC_006369.1.

Genome annotation databases

EnsemblBacteriaiCAH14345; CAH14345; lpl0115.
GeneIDi3115996.
KEGGilpf:lpl0115.
PATRICi22313667. VBILegPne33733_0184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628337 Genomic DNA. Translation: CAH14345.1 .
RefSeqi WP_011214399.1. NC_006369.1.
YP_125492.1. NC_006369.1.

3D structure databases

ProteinModelPortali Q5X0A6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 297245.lpl0115.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH14345 ; CAH14345 ; lpl0115 .
GeneIDi 3115996.
KEGGi lpf:lpl0115.
PATRICi 22313667. VBILegPne33733_0184.

Organism-specific databases

LegioListi lpl0115.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi GLEVANC.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci LPNE297245:GJD4-119-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
    Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
    Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Lens.

Entry informationi

Entry nameiGCSPA_LEGPL
AccessioniPrimary (citable) accession number: Q5X0A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3