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Q5WZT6

- GLSA_LEGPL

UniProt

Q5WZT6 - GLSA_LEGPL

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Protein

Glutaminase

Gene
glsA, lpl0295
Organism
Legionella pneumophila (strain Lens)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671Substrate By similarity
Binding sitei118 – 1181Substrate By similarity
Binding sitei161 – 1611Substrate By similarity
Binding sitei168 – 1681Substrate By similarity
Binding sitei192 – 1921Substrate By similarity
Binding sitei244 – 2441Substrate By similarity
Binding sitei262 – 2621Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciLPNE297245:GJD4-313-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:lpl0295
OrganismiLegionella pneumophila (strain Lens)
Taxonomic identifieri297245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000002517: Chromosome

Organism-specific databases

LegioListilpl0295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310GlutaminaseUniRule annotationPRO_1000079076Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi297245.lpl0295.

Structurei

3D structure databases

ProteinModelPortaliQ5WZT6.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiMSIAVWS.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5WZT6-1 [UniParc]FASTAAdd to Basket

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MSSKLLTIQL LEELVHAAEL NQEGKTADYI PELANVNQEL TAIAVQTLGE    50
KTLAYSNNPL HPVTLQSTGK MIPLIGLLEE FGADQLFEWV KVEPSGDDFA 100
SITRLEQFGP KPSNPMLNAG AIALCSRIPG VGEQQFRWLE HWVQKLFNQR 150
LSINPLVFAS EKRTGNRNRA LAYLLKSRNN LGADVHETLD LYFALCSYEA 200
MLDQMLYLPT LLANSGKDSD TGEQILSMET CKITLAIMAT CGLYDETGTH 250
MVKTGMPAKS GVSGYTIAVV PGKAGIVVLS PRVNAKGNSI RGEIMLEGLS 300
KAMNWHFALP 310
Length:310
Mass (Da):33,937
Last modified:November 23, 2004 - v1
Checksum:i9BD5E5427825C9E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628337 Genomic DNA. Translation: CAH14526.1.
RefSeqiYP_125662.1. NC_006369.1.

Genome annotation databases

EnsemblBacteriaiCAH14526; CAH14526; lpl0295.
GeneIDi3115750.
KEGGilpf:lpl0295.
PATRICi22314057. VBILegPne33733_0379.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628337 Genomic DNA. Translation: CAH14526.1 .
RefSeqi YP_125662.1. NC_006369.1.

3D structure databases

ProteinModelPortali Q5WZT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 297245.lpl0295.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH14526 ; CAH14526 ; lpl0295 .
GeneIDi 3115750.
KEGGi lpf:lpl0295.
PATRICi 22314057. VBILegPne33733_0379.

Organism-specific databases

LegioListi lpl0295.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi MSIAVWS.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci LPNE297245:GJD4-313-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
    Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
    Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Lens.

Entry informationi

Entry nameiGLSA_LEGPL
AccessioniPrimary (citable) accession number: Q5WZT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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