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Q5WZL4

- EFTU_LEGPL

UniProt

Q5WZL4 - EFTU_LEGPL

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Protein
Elongation factor Tu
Gene
tuf1, lpl0355
tuf2, lpl0367
Organism
Legionella pneumophila (strain Lens)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTP By similarity
Nucleotide bindingi81 – 855GTP By similarity
Nucleotide bindingi136 – 1394GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. GTPase activity Source: InterPro
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLPNE297245:GJD4-383-MONOMER.
LPNE297245:GJD4-397-MONOMER.

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Elongation factor Tu
Short name:
EF-Tu
Gene namesi
Name:tuf1
Ordered Locus Names:lpl0355
AND
Name:tuf2
Ordered Locus Names:lpl0367
OrganismiLegionella pneumophila (strain Lens)
Taxonomic identifieri297245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000002517: Chromosome
LegioListilpl0355.
lpl0367.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Elongation factor TuUniRule annotation
PRO_0000337422Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi297245.lpl0367.

Structurei

3D structure databases

ProteinModelPortaliQ5WZL4.
SMRiQ5WZL4. Positions 2-395.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 206197tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 268G1 By similarity
Regioni60 – 645G2 By similarity
Regioni81 – 844G3 By similarity
Regioni136 – 1394G4 By similarity
Regioni174 – 1763G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiDYAEIDG.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5WZL4-1 [UniParc]FASTAAdd to Basket

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MAKEKFERKK PHVNVGTIGH VDHGKTTLTA AITTIMAKKY GGTAKAYDQI    50
DAAPEERERG ITISTAHVEY ESASRHYAHV DCPGHADYVK NMITGAAQMD 100
GAILVVSAAD GPMPQTREHI LLSRQVGVPY IVVFMNKADM VDDPELLELV 150
EMEVRDLLSS YDFPGDDIPI IVGSALKALE GEDSDIGVKA IEKLVETMDS 200
YIPEPVRNID KPFLLPIEDV FSISGRGTVV TGRVESGIVK VGEEVEIVGI 250
RDTQKTTCTG VEMFRKLLDE GRAGDNVGVL LRGTKRDEVE RGQVLAKPGT 300
IKPHTKFEAE VYVLSKEEGG RHTPFFNGYR PQFYFRTTDV TGTCDLPSGV 350
EMVMPGDNVQ LVVSLHAPIA MDEGLRFAIR EGGRTVGAGV VAKIIE 396
Length:396
Mass (Da):43,193
Last modified:November 23, 2004 - v1
Checksum:i8069FEDB74B131C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628337 Genomic DNA. Translation: CAH14586.1.
CR628337 Genomic DNA. Translation: CAH14598.1.
RefSeqiYP_125722.1. NC_006369.1.
YP_125734.1. NC_006369.1.

Genome annotation databases

EnsemblBacteriaiCAH14586; CAH14586; lpl0355.
CAH14598; CAH14598; lpl0367.
GeneIDi3114709.
3116352.
KEGGilpf:lpl0355.
lpf:lpl0367.
PATRICi22314201. VBILegPne33733_0443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628337 Genomic DNA. Translation: CAH14586.1 .
CR628337 Genomic DNA. Translation: CAH14598.1 .
RefSeqi YP_125722.1. NC_006369.1.
YP_125734.1. NC_006369.1.

3D structure databases

ProteinModelPortali Q5WZL4.
SMRi Q5WZL4. Positions 2-395.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 297245.lpl0367.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH14586 ; CAH14586 ; lpl0355 .
CAH14598 ; CAH14598 ; lpl0367 .
GeneIDi 3114709.
3116352.
KEGGi lpf:lpl0355.
lpf:lpl0367.
PATRICi 22314201. VBILegPne33733_0443.

Organism-specific databases

LegioListi lpl0355.
lpl0367.

Phylogenomic databases

eggNOGi COG0050.
HOGENOMi HOG000229290.
KOi K02358.
OMAi DYAEIDG.
OrthoDBi EOG6R5C6X.

Enzyme and pathway databases

BioCyci LPNE297245:GJD4-383-MONOMER.
LPNE297245:GJD4-397-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_B. EF_Tu_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
    Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
    Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Lens.

Entry informationi

Entry nameiEFTU_LEGPL
AccessioniPrimary (citable) accession number: Q5WZL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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