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Protein

3-dehydroquinate dehydratase

Gene

aroQ

Organism
Legionella pneumophila (strain Lens)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a trans-dehydration via an enolate intermediate.UniRule annotation

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (aroF)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei18 – 181Transition state stabilizerUniRule annotation
Active sitei23 – 231Proton acceptorUniRule annotation
Binding sitei75 – 751SubstrateUniRule annotation
Binding sitei81 – 811SubstrateUniRule annotation
Binding sitei88 – 881SubstrateUniRule annotation
Active sitei101 – 1011Proton donorUniRule annotation
Binding sitei112 – 1121SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

BioCyciLPNE297245:GJD4-537-MONOMER.
UniPathwayiUPA00053; UER00086.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydrataseUniRule annotation (EC:4.2.1.10UniRule annotation)
Short name:
3-dehydroquinaseUniRule annotation
Alternative name(s):
Type II DHQaseUniRule annotation
Gene namesi
Name:aroQUniRule annotation
Ordered Locus Names:lpl0506
OrganismiLegionella pneumophila (strain Lens)
Taxonomic identifieri297245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
Proteomesi
  • UP000002517 Componenti: Chromosome

Organism-specific databases

LegioListilpl0506.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1451453-dehydroquinate dehydratasePRO_1000077048Add
BLAST

Interactioni

Subunit structurei

Homododecamer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5WZ76.
SMRiQ5WZ76. Positions 1-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni102 – 1032Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the type-II 3-dehydroquinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000217278.
KOiK03786.
OMAiRREPGHY.

Family and domain databases

CDDicd00466. DHQase_II. 1 hit.
Gene3Di3.40.50.9100. 1 hit.
HAMAPiMF_00169. AroQ. 1 hit.
InterProiIPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
[Graphical view]
PANTHERiPTHR21272. PTHR21272. 1 hit.
PfamiPF01220. DHquinase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF001399. DHquinase_II. 1 hit.
ProDomiPD004527. DHquinase_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52304. SSF52304. 1 hit.
TIGRFAMsiTIGR01088. aroQ. 1 hit.
PROSITEiPS01029. DEHYDROQUINASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5WZ76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKILVLHGP NLNLLGSREP SIYGHASLTQ INGDLIQEAD NAGIRLSCFQ
60 70 80 90 100
SNAEAELIQA VHQAGIDKIN YIIINPAAFT HTSIALRDAL SAVAIPFIEV
110 120 130 140
HLSNIFSRET FRHHSYFSDI AVGVISGLGT KGYLLALQAI IKELK
Length:145
Mass (Da):15,774
Last modified:November 23, 2004 - v1
Checksum:iD86C832939F54F26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628337 Genomic DNA. Translation: CAH14736.1.
RefSeqiWP_010946213.1. NC_006369.1.

Genome annotation databases

EnsemblBacteriaiCAH14736; CAH14736; lpl0506.
KEGGilpf:lpl0506.
PATRICi22314511. VBILegPne33733_0597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628337 Genomic DNA. Translation: CAH14736.1.
RefSeqiWP_010946213.1. NC_006369.1.

3D structure databases

ProteinModelPortaliQ5WZ76.
SMRiQ5WZ76. Positions 1-145.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH14736; CAH14736; lpl0506.
KEGGilpf:lpl0506.
PATRICi22314511. VBILegPne33733_0597.

Organism-specific databases

LegioListilpl0506.

Phylogenomic databases

HOGENOMiHOG000217278.
KOiK03786.
OMAiRREPGHY.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00086.
BioCyciLPNE297245:GJD4-537-MONOMER.

Family and domain databases

CDDicd00466. DHQase_II. 1 hit.
Gene3Di3.40.50.9100. 1 hit.
HAMAPiMF_00169. AroQ. 1 hit.
InterProiIPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
[Graphical view]
PANTHERiPTHR21272. PTHR21272. 1 hit.
PfamiPF01220. DHquinase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF001399. DHquinase_II. 1 hit.
ProDomiPD004527. DHquinase_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52304. SSF52304. 1 hit.
TIGRFAMsiTIGR01088. aroQ. 1 hit.
PROSITEiPS01029. DEHYDROQUINASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAROQ_LEGPL
AccessioniPrimary (citable) accession number: Q5WZ76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.