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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Legionella pneumophila (strain Lens)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei352 – 3521Proton donorUniRule annotation
Active sitei383 – 3831UniRule annotation
Active sitei487 – 4871UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciLPNE297245:GJD4-855-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:lpl0796
OrganismiLegionella pneumophila (strain Lens)
Taxonomic identifieri297245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000002517 Componenti: Chromosome

Organism-specific databases

LegioListilpl0796.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Glucose-6-phosphate isomerasePRO_0000180662Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi297245.lpl0796.

Structurei

3D structure databases

ProteinModelPortaliQ5WYE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5WYE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRNSMKSHT ELLSWSLLQK EAKRVRLNSD SQPRVVPDSN NYESRKQINC
60 70 80 90 100
IVYDYSRQRV NRTIIDLLID LANEVKLPEK IDNLINGKKI NISENRPALH
110 120 130 140 150
TALRDLSNKS ILIDGLDIMS EVVSTREKIR MISNRIREKK WLGYSGLPIT
160 170 180 190 200
DVVNIGIGGS DLGPRVCIHA LSNYVSKEFN YHFISDVDPA SFNDVIVKIN
210 220 230 240 250
PETTLFIVSS KSFTTKETLL NARKAFALYE DRASIDQHFI AVTAHPERAH
260 270 280 290 300
QIGIKTVLPI WDWVGGRFSF CSAVNLITAI AIGYEQFVEL LAGAHDVDTH
310 320 330 340 350
VQFTDFKNNI PVLMALIGIW NNNFLNIHNL LILTYSKKLE YFVPYVQQLD
360 370 380 390 400
MESNGKSIDV NGRMVGYATG PIVWGGLGNQ AQHSYFQLLC QGTHRCVGDF
410 420 430 440 450
ITLKTNDEHE INSMCHYKMK VLSEGIQTIE NPYGYIPGNM PMNHLILSDC
460 470 480 490
SPYTLGALVA LYEHKIFVQS VIWNINPFDQ PGIESAKSAH REITLSSEL
Length:499
Mass (Da):56,426
Last modified:November 22, 2004 - v1
Checksum:i888C01CD7B641D93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628337 Genomic DNA. Translation: CAH15030.1.
RefSeqiWP_011214963.1. NC_006369.1.
YP_126158.1. NC_006369.1.

Genome annotation databases

EnsemblBacteriaiCAH15030; CAH15030; lpl0796.
KEGGilpf:lpl0796.
PATRICi22315149. VBILegPne33733_0909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628337 Genomic DNA. Translation: CAH15030.1.
RefSeqiWP_011214963.1. NC_006369.1.
YP_126158.1. NC_006369.1.

3D structure databases

ProteinModelPortaliQ5WYE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi297245.lpl0796.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH15030; CAH15030; lpl0796.
KEGGilpf:lpl0796.
PATRICi22315149. VBILegPne33733_0909.

Organism-specific databases

LegioListilpl0796.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciLPNE297245:GJD4-855-MONOMER.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
    Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
    Nat. Genet. 36:1165-1173(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Lens.

Entry informationi

Entry nameiG6PI_LEGPL
AccessioniPrimary (citable) accession number: Q5WYE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2005
Last sequence update: November 22, 2004
Last modified: March 31, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.