Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5WYE0 (G6PI_LEGPL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:lpl0796
OrganismLegionella pneumophila (strain Lens) [Complete proteome] [HAMAP]
Taxonomic identifier297245 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 499499Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180662

Sites

Active site3521Proton donor By similarity
Active site3831 By similarity
Active site4871 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5WYE0 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 888C01CD7B641D93

FASTA49956,426
        10         20         30         40         50         60 
MIRNSMKSHT ELLSWSLLQK EAKRVRLNSD SQPRVVPDSN NYESRKQINC IVYDYSRQRV 

        70         80         90        100        110        120 
NRTIIDLLID LANEVKLPEK IDNLINGKKI NISENRPALH TALRDLSNKS ILIDGLDIMS 

       130        140        150        160        170        180 
EVVSTREKIR MISNRIREKK WLGYSGLPIT DVVNIGIGGS DLGPRVCIHA LSNYVSKEFN 

       190        200        210        220        230        240 
YHFISDVDPA SFNDVIVKIN PETTLFIVSS KSFTTKETLL NARKAFALYE DRASIDQHFI 

       250        260        270        280        290        300 
AVTAHPERAH QIGIKTVLPI WDWVGGRFSF CSAVNLITAI AIGYEQFVEL LAGAHDVDTH 

       310        320        330        340        350        360 
VQFTDFKNNI PVLMALIGIW NNNFLNIHNL LILTYSKKLE YFVPYVQQLD MESNGKSIDV 

       370        380        390        400        410        420 
NGRMVGYATG PIVWGGLGNQ AQHSYFQLLC QGTHRCVGDF ITLKTNDEHE INSMCHYKMK 

       430        440        450        460        470        480 
VLSEGIQTIE NPYGYIPGNM PMNHLILSDC SPYTLGALVA LYEHKIFVQS VIWNINPFDQ 

       490 
PGIESAKSAH REITLSSEL 

« Hide

References

[1]"Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Lens.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR628337 Genomic DNA. Translation: CAH15030.1.
RefSeqYP_126158.1. NC_006369.1.

3D structure databases

ProteinModelPortalQ5WYE0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING297245.lpl0796.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH15030; CAH15030; lpl0796.
GeneID3116331.
KEGGlpf:lpl0796.
PATRIC22315149. VBILegPne33733_0909.

Organism-specific databases

LegioListlpl0796.
CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261370.
KOK01810.
OMANCHFVAN.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycLPNE297245:GJD4-855-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_LEGPL
AccessionPrimary (citable) accession number: Q5WYE0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways