Reviewed, UniProtKB/Swiss-Prot Q5WY16 (KMO_LEGPL)

Names and origin

Protein names

Recommended name:
    Kynurenine 3-monooxygenase
    EC=1.14.13.9
Alternative name(s):
    Kynurenine 3-hydroxylase

Gene names

Name:	kmo
Ordered Locus Names:	lpl0923

Organism

Legionella pneumophila (strain Lens) [Complete proteome] [HAMAP]

Taxonomic identifier

297245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	Kynurenine 3-monooxygenase		PRO_0000361940

Sequences

	Sequence		Length	Mass (Da)
	Q5WY16-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: BFF51B7443F9E38B	FASTA	449	51,334
	10 20 30 40 50 60 MKHITIIGAG LAGTLCGLYL ARRGYEVELF ESRPDIRNSP TDYGRSINLA LSCRGITALK 70 80 90 100 110 120 AMNLLSEVNK IMVPMRARAI HEANGEIHYQ PFGRHIDEYI NAISRSDLNA LLLNKAKLCP 130 140 150 160 170 180 NIKLHFNMKL HSLDIHNKKI KFENKNGDFV EASYHRLIGA DGAPSHVRDM LKNEGIVSAS 190 200 210 220 230 240 RDFLSHGYKE LSISKKHTKG MAREHLHLWP RDSFMLLGNP NPDDSITGSL FLANEGKDSF 250 260 270 280 290 300 AELNNEEKLH LFFKTQFPDA YAAMPNLVQE FFGNPTGHLS TIQCSPWYYK DECLLIGDAA 310 320 330 340 350 360 HGIIPFFGQG MNSAFEDCRI LDELLDEYQD DWSRVNSVFY EHRKVNTDAI AKMSMDNYHE 370 380 390 400 410 420 IHSDIRNPKF ILQKQIEREL MLRYPEHYVS MHVLVMFTNT PYAKAMAIGE LQSGLLEQIC 430 440 FPITDIKELN WQEVEKLLSL YDKKLAKII

References

[1]

"Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity." Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C. Nat. Genet. 36:1165-1173(2004) [PubMed: 15467720] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR628337 Genomic DNA. Translation: CAH15157.1.
RefSeq	YP_126282.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WY16.
Genome annotation databases
GeneID	3114288.
GenomeReviews	Gene locus lpl0923 in contig CR628337_GR.
KEGG	lpf:lpl0923.
NMPDR	fig|297245.3.peg.1773.
Organism-specific databases
LegioList	lpl0923.
CMR	Search...
Phylogenomic databases
HOGENOM	Q5WY16.
OMA	LHAIMPS.
Enzyme and pathway databases
BioCyc	LPNE297245:LPL0923-MON.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. IPR003042. Rng_hydrolase-like. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_LEGPL

Accession

Primary (citable) accession number: Q5WY16

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	November 23, 2004
Last modified:	November 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)