Q5WX50 (HGD_LEGPL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homogentisate 1,2-dioxygenase
EC=1.13.11.5

Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase

Gene names

Name:	hmgA
Ordered Locus Names:	lpl1248

Organism

Legionella pneumophila (strain Lens) [Complete proteome] [HAMAP]

Taxonomic identifier

297245 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella › Legionella pneumophila

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334		PRO_0000225789
Sites
	Metal binding	318	1	Iron By similarity
	Metal binding	324	1	Iron By similarity
	Metal binding	354	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5WX50 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 19BEAF0E3A153641	FASTA	416	47,451
	10 20 30 40 50 60 MYLQGFGNYH HSEAVKGALP PNQNSPQHCS LGLYAEQLSG TSFTRPRHNN LRSWLYRILP 70 80 90 100 110 120 TVTQGTYYPY EFNIMQPLVD ELSPNAMRWS PLYNSSQIKC DFVEGLFHIA GSPLVNAYTY 130 140 150 160 170 180 YCNHSMSDKY FANNDGELLF VPYTGEIHLH TEFGKLMLSS GSIAVIPRGV KFKVEVISKE 190 200 210 220 230 240 AKGYLCENSG NPLTLPQLGP IGANGLANPR HFQYPVAAFE NSVGEHTIIC KNQKKLWFTV 250 260 270 280 290 300 CNHSPLNVVA WHGNYAPYCY DLSLFNTINT VSFDHPDPSI FTVLTSESEI PGVSNLDFVI 310 320 330 340 350 360 FPPRWMVAEH TFRPPYFHRN YMNELMGLVY GEYDAKKEGF IPGGISIHNC MTPHGPDYES 370 380 390 400 410 YEIAASQDLK PNYINSLAFM FETKDYWQVT EQAYRHPSRQ IDYLNCWQGF KIEFSQ

References

[1]

"Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity." Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C. Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Lens.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR628337 Genomic DNA. Translation: CAH15487.1.
RefSeq	YP_126599.1. NC_006369.1.
3D structure databases
ProteinModelPortal	Q5WX50.
ModBase	Search...
Protein-protein interaction databases
STRING	297245.lpl1248.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAH15487; CAH15487; lpl1248.
GeneID	3114748.
KEGG	lpf:lpl1248.
PATRIC	22316143. VBILegPne33733_1401.
Organism-specific databases
LegioList	lpl1248.
CMR	Search...
Phylogenomic databases
eggNOG	COG3508.
HOGENOM	HOG000139824.
KO	K00451.
OMA	AVTKWGL.
ProtClustDB	PRK05341.
Enzyme and pathway databases
BioCyc	LPNE297245:GJD4-1339-MONOMER.
UniPathway	UPA00139; UER00339.
Family and domain databases
Gene3D	2.60.120.10. 2 hits.
HAMAP	MF_00334. Homogentis_dioxygen.
InterPro	IPR005708. Homogentis_dOase. IPR022950. Homogentis_dOase_bac. IPR014710. RmlC-like_jellyroll. IPR011051. RmlC_Cupin. [Graphical view]
PANTHER	PTHR11056. PTHR11056. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_LEGPL

Accession

Primary (citable) accession number: Q5WX50

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program