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Q5WWX7 (LPXB1_LEGPL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase 1

EC=2.4.1.182
Gene names
Name:lpxB1
Ordered Locus Names:lpl1322
OrganismLegionella pneumophila (strain Lens) [Complete proteome] [HAMAP]
Taxonomic identifier297245 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Lipid-A-disaccharide synthase 1 HAMAP-Rule MF_00392
PRO_0000255190

Sequences

Sequence LengthMass (Da)Tools
Q5WWX7 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: C6C2C4C471B542B7

FASTA38442,663
        10         20         30         40         50         60 
MPNASRVVIV AGEESGDHHA AELVKQLKAV YPDLEISGIG GKHLRAAGVH LISDLTRYAV 

        70         80         90        100        110        120 
TGLTEIIPFL KIFRKAFQDI KQHLSTQKPD LLILVDYPAF NLRLAKYAKK KLGLKIIYYI 

       130        140        150        160        170        180 
SPQIWAWKGK RIHLIKDCID KMAVIFPFEK TIYENAGVPV SFVGHPLVKK IAAAKDKHSS 

       190        200        210        220        230        240 
RTSLGLPLNE PIIALLPGSR HSEIERHIPI LVNTAKLLTL DSPKLRFVVP IAGTINPDKV 

       250        260        270        280        290        300 
KAYFSNQNLT VTFIQGQAIE CMSAADFVIV ASGTASLECA LLEKPMCIIY KSSFLTYVAA 

       310        320        330        340        350        360 
MYFIKVKFLG LCNLLANKMM VPEFLQYDCN AIELSRYISN FHNNPNQPES MINQLAKLKE 

       370        380 
SLSSSQADCS LFDLVVAELP EKNA 

« Hide

References

[1]"Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Lens.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR628337 Genomic DNA. Translation: CAH15562.1.
RefSeqYP_126672.1. NC_006369.1.

3D structure databases

ProteinModelPortalQ5WWX7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING297245.lpl1322.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

DNASU3114168.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH15562; CAH15562; lpl1322.
GeneID3114168.
KEGGlpf:lpl1322.
PATRIC22316299. VBILegPne33733_1478.

Organism-specific databases

LegioListlpl1322.
CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018004.
KOK00748.
OMAIARMLVN.
OrthoDBEOG6FBWZR.
ProtClustDBCLSK832751.

Enzyme and pathway databases

BioCycLPNE297245:GJD4-1425-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB1_LEGPL
AccessionPrimary (citable) accession number: Q5WWX7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways