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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Legionella pneumophila (strain Lens)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi375 – 382ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:lpl1783
OrganismiLegionella pneumophila (strain Lens)
Taxonomic identifieri297245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
Proteomesi
  • UP000002517 Componenti: Chromosome

Organism-specific databases

LegioListilpl1783.

Subcellular locationi

Q5WVN2:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalUniRule annotationAdd BLAST21
Transmembranei66 – 88HelicalUniRule annotationAdd BLAST23
Transmembranei141 – 161HelicalUniRule annotationAdd BLAST21
Transmembranei162 – 182HelicalUniRule annotationAdd BLAST21
Transmembranei257 – 277HelicalUniRule annotationAdd BLAST21
Transmembranei278 – 298HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925861 – 588Lipid A export ATP-binding/permease protein MsbAAdd BLAST588

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5WVN2.
SMRiQ5WVN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 310ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini342 – 576ABC transporterUniRule annotationAdd BLAST235

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK11085.
OMAiHERVQGM.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5WVN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNNLPIKSR LLYKRLLSYV KPFWPVLLLG VLANILYSGI DAGFTYMTKL
60 70 80 90 100
FLDKSFITID LDFVKQIPLI VLIGITLRGL VSSLGSYCMT WVARSVVKVL
110 120 130 140 150
RQTVFSHIIH LPADYYDEAT SGQLLSKILY DVEQVAQVSA DALTDFIQNI
160 170 180 190 200
CLVIGLLTVM MVICWQLSLM FLLTIPFVGI IVNYTNKRVR RISHKVQKTM
210 220 230 240 250
GEVTEIASEA IEGYRVVRIF GGERYEITKF NKATEYSRKN DMKVAISKAI
260 270 280 290 300
NVSGVQLVIA IGIAMIIMAA IHLSTVITIS AGSFLAIIAA MLQLIKPMKT
310 320 330 340 350
LTTLNATIQR GLAGAESVFN LLDLPLERNN GLILKDKIRG EIEFKHVYHA
360 370 380 390 400
YRQGQNILHD VNFVIEAGTS VALVGHSGSG KTTIASLLPR FYELSQGMIT
410 420 430 440 450
LDGMPIQQLS LESLRKQMSL VSQNVTLFND TLANNIAYGR FDASREQIIT
460 470 480 490 500
AAKLAYADEF IKQLPDGYDT RVGENGVLLS GGQRQRIAIA RAILKDAPIL
510 520 530 540 550
ILDEATSALD SESEHYIQAA LEQVMNGRTT LIIAHRLSTI KHAHKIIVMQ
560 570 580
HGRIVEQGSH QELLDMDGHY AQLYKVQQFG RVNEEVVV
Length:588
Mass (Da):65,454
Last modified:November 23, 2004 - v1
Checksum:iB5ED62ABF35CBB1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628337 Genomic DNA. Translation: CAH16022.1.

Genome annotation databases

EnsemblBacteriaiCAH16022; CAH16022; lpl1783.
KEGGilpf:lpl1783.

Similar proteinsi

Entry informationi

Entry nameiMSBA_LEGPL
AccessioniPrimary (citable) accession number: Q5WVN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 23, 2004
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families